{"id":18,"date":"2023-10-19T18:24:16","date_gmt":"2023-10-20T01:24:16","guid":{"rendered":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/?page_id=18"},"modified":"2025-12-12T13:13:30","modified_gmt":"2025-12-12T21:13:30","slug":"home","status":"publish","type":"page","link":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/","title":{"rendered":"Home"},"content":{"rendered":"<div id='full_slider_1'  class='avia-fullwidth-slider main_color avia-shadow   avia-builder-el-0  el_before_av_three_fifth  avia-builder-el-first   container_wrap sidebar_right'  >\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0\">\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__0 .avia-caption-content{\nfont-size:13px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__0 .avia-caption-content p{\nfont-size:13px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__1 .avia-caption-content{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__1 .avia-caption-content p{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__2 .avia-caption-content{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__2 .avia-caption-content p{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__3 .avia-caption-content{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__3 .avia-caption-content p{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__4 .avia-caption-content{\nfont-size:14px;\n}\n#top .avia-slideshow .av-slideshow-caption.av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__4 .avia-caption-content p{\nfont-size:14px;\n}\n<\/style>\n<div  class='avia-slideshow av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0 avia-slideshow-featured av_slideshow_full avia-slide-slider av-slideshow-ui av-control-default av-slideshow-autoplay av-loop-endless av-loop-manual-endless av-default-height-applied  image_no_stretch avia-slideshow-1' data-slideshow-options=\"{&quot;animation&quot;:&quot;slide&quot;,&quot;autoplay&quot;:true,&quot;loop_autoplay&quot;:&quot;endless&quot;,&quot;interval&quot;:6,&quot;loop_manual&quot;:&quot;manual-endless&quot;,&quot;autoplay_stopper&quot;:false,&quot;noNavigation&quot;:false,&quot;bg_slider&quot;:false,&quot;transitionSpeed&quot;:1000,&quot;keep_padding&quot;:false,&quot;hoverpause&quot;:false,&quot;show_slide_delay&quot;:0}\"  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><ul class='avia-slideshow-inner ' style='padding-bottom: 53.75%;'><li  class='avia-slideshow-slide av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__0  slide-1 slide-odd'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__0 caption_fullwidth caption_right caption_right_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Dynamics of Zoonotic Infections<\/h2><div class='avia-caption-content av_inherit_color'  itemprop=\"description\" ><p>We build mathematical models for the spread of infections in animal reservoirs, at the animal-human interface, and in the human population. We also develop new tools to analyze laboratory, clinical and field data for these pathogens, and to design better ways to limit their health impacts.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-41 avia-img-lazy-loading-not-41\"  src=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-content\/uploads\/sites\/318\/2023\/10\/zoonotic2-800x430.png\" width=\"800\" height=\"430\" title='zoonotic2' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class='avia-slideshow-slide av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__1  slide-2 slide-even'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__1 caption_fullwidth caption_right caption_right_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Leptospirosis in California Sea Lions<\/h2><div class='avia-caption-content '  itemprop=\"description\" ><p>Leptospirosis causes annual outbreaks in the California sea lion population, and leads to large numbers of animals stranding and dying each fall. With a team of collaborators, we are conducting fieldwork, clinical studies and modeling analyses to understand what factors drive outbreak intensity and how the pathogen persists in the ecosystem. We are also gaining basic insights into the ecology and epidemiology of this important zoonotic disease.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-42 avia-img-lazy-loading-not-42\"  src=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-content\/uploads\/sites\/318\/2023\/10\/sealions-800x430.jpg\" width=\"800\" height=\"430\" title='sealions' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class='avia-slideshow-slide av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__2  slide-3 slide-odd'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__2 caption_fullwidth caption_right caption_right_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Evolutionary emergence of new pathogens<\/h2><div class='avia-caption-content '  itemprop=\"description\" ><p>Viruses such as H5N1 influenza, SARS-CoV and canine parvovirus can mutate to adapt to new host species, and many pathogens can evolve to become drug-resistant or escape from vaccines. We are developing new theory to study how evolutionary processes at different scales can lead to emergence of novel pathogens or strains.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-38 avia-img-lazy-loading-not-38\"  src=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-content\/uploads\/sites\/318\/2023\/10\/adap_mutation1-800x430.png\" width=\"800\" height=\"430\" title='adap_mutation1' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class='avia-slideshow-slide av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__3  slide-4 slide-even'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__3 caption_fullwidth caption_right caption_right_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Mpox in the Congo Basin<\/h2><div class='avia-caption-content '  itemprop=\"description\" ><p>Since the eradication of smallpox, incidence of human mpox (previously monkeypox) has risen sharply in the Democratic Republic of the Congo. We are working with epidemiologists to understand what is driving the emergence of mpox, and to quantify the contributions of zoonotic spillover, human-to-human transmission, and other factors.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-45 avia-img-lazy-loading-not-45\"  src=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-content\/uploads\/sites\/318\/2023\/10\/monkeypox-1-800x430.jpg\" width=\"800\" height=\"430\" title='monkeypox' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><li  class='avia-slideshow-slide av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__4  slide-5 slide-odd'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-lnxxhsjt-9906e10d359475edc4030c61e2567ca0__4 caption_fullwidth caption_right caption_right_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Childhood imprinting to influenza A viruses<\/h2><div class='avia-caption-content '  itemprop=\"description\" ><p>Influenza viruses persistently spill over from animals into humans, where they threaten to cause pandemics. A central tenet of influenza pandemic risk assessment has always been that the entire human population lacks immunity against unfamiliar, animal-origin viruses. However, our recent study showed that large fractions of the human population actually do have pre-existing immunity against two avian influenza viruses of great concern for pandemic emergence in humans. Individuals gain lifelong, partial protection against influenza viruses in the same genetic group as the viruses they encountered as children.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-542 avia-img-lazy-loading-not-542\"  src=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-content\/uploads\/sites\/318\/2025\/12\/Flu_icon3-801x430.png\" width=\"801\" height=\"430\" title='Flu_icon3' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><\/ul><div class='avia-slideshow-arrows avia-slideshow-controls' ><a href='#prev' class='prev-slide  avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='left-open-big' data-av_iconset='svg_entypo-fontello' tabindex='-1' title=\"Previous\"><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-1' aria-describedby='av-svg-desc-1' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-1'>Previous<\/title>\n<desc id='av-svg-desc-1'>Previous<\/desc>\n<path d=\"M14.464 27.84q0.832 0.832 0 1.536-0.832 0.832-1.536 0l-12.544-12.608q-0.768-0.768 0-1.6l12.544-12.608q0.704-0.832 1.536 0 0.832 0.704 0 1.536l-11.456 11.904z\"><\/path>\n<\/svg><span class='avia_hidden_link_text'>Previous<\/span><\/a><a href='#next' class='next-slide  avia-svg-icon avia-font-svg_entypo-fontello' data-av_svg_icon='right-open-big' data-av_iconset='svg_entypo-fontello' tabindex='-1' title=\"Next\"><svg version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"15\" height=\"32\" viewBox=\"0 0 15 32\" preserveAspectRatio=\"xMidYMid meet\" aria-labelledby='av-svg-title-2' aria-describedby='av-svg-desc-2' role=\"graphics-symbol\" aria-hidden=\"true\">\n<title id='av-svg-title-2'>Next<\/title>\n<desc id='av-svg-desc-2'>Next<\/desc>\n<path d=\"M0.416 27.84l11.456-11.84-11.456-11.904q-0.832-0.832 0-1.536 0.832-0.832 1.536 0l12.544 12.608q0.768 0.832 0 1.6l-12.544 12.608q-0.704 0.832-1.536 0-0.832-0.704 0-1.536z\"><\/path>\n<\/svg><span class='avia_hidden_link_text'>Next<\/span><\/a><\/div><div class='avia-slideshow-dots avia-slideshow-controls'><a href='#1' class='goto-slide active' >1<\/a><a href='#2' class='goto-slide ' >2<\/a><a href='#3' class='goto-slide ' >3<\/a><a href='#4' class='goto-slide ' >4<\/a><a href='#5' class='goto-slide ' >5<\/a><\/div><\/div><\/div><div id='after_full_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-18'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-23cla-2fbf63c607e1eba838229166d7ac4268 av_three_fifth  avia-builder-el-1  el_after_av_slideshow_full  el_before_av_two_fifth  avia-builder-el-first  first flex_column_div  '     ><section  class='av_textblock_section av-lnxxb9gn-0209aeb8e5f6060af4b840cdcc36ce6b '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><div class=\"span3\">\n<div class=\"well-research\">\n<h3>Our Research Program<\/h3>\n<hr \/>\n<p>We combine mathematical and computer models with field and laboratory data to understand how infectious diseases spread and evolve, and how to reduce their health impacts.<\/p>\n<p>We focus on zoonotic diseases, which are diseases that transmit from animals to humans. Zoonoses make up 60% of all human pathogens and 75% of emerging infections, but are less well-studied than other human infections because their natural history crosses traditional scientific disciplines. We use models to integrate ideas and data from many disciplines, with the aim of answering big questions about zoonotic and emerging pathogens.<\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/research\/\">Click here to learn more.<\/a><\/p>\n<\/div>\n<\/div>\n<\/div><\/section><\/div>\n<div  class='flex_column av-1cya6-c05d9bb85feabfc755a79d1a2e3b12eb av_two_fifth  avia-builder-el-3  el_after_av_three_fifth  avia-builder-el-last  flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lnyuuwmk-17180f2cef3541a3c4a605df2a2d7efc\">\n#top .av-special-heading.av-lnyuuwmk-17180f2cef3541a3c4a605df2a2d7efc{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-lnyuuwmk-17180f2cef3541a3c4a605df2a2d7efc .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-lnyuuwmk-17180f2cef3541a3c4a605df2a2d7efc .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-lnyuuwmk-17180f2cef3541a3c4a605df2a2d7efc av-special-heading-h5 blockquote modern-quote  avia-builder-el-4  el_before_av_textblock  avia-builder-el-first '><h5 class='av-special-heading-tag '  itemprop=\"headline\"  >News<\/h5><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-14bei-09a986f4833d675620ac739d5c57edb2 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" >\n\n\n<div id=\"wpv-view-layout-71\" class=\"js-wpv-view-layout js-wpv-layout-responsive js-wpv-view-layout-71\" data-viewnumber=\"71\" data-pagination=\"{&quot;id&quot;:&quot;71&quot;,&quot;query&quot;:&quot;normal&quot;,&quot;type&quot;:&quot;disabled&quot;,&quot;effect&quot;:&quot;fade&quot;,&quot;duration&quot;:500,&quot;speed&quot;:5,&quot;pause_on_hover&quot;:&quot;enabled&quot;,&quot;stop_rollover&quot;:&quot;false&quot;,&quot;cache_pages&quot;:&quot;enabled&quot;,&quot;preload_images&quot;:&quot;enabled&quot;,&quot;preload_pages&quot;:&quot;enabled&quot;,&quot;preload_reach&quot;:1,&quot;spinner&quot;:&quot;builtin&quot;,&quot;spinner_image&quot;:&quot;https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-content\/plugins\/wp-views\/embedded\/res\/img\/ajax-loader.gif&quot;,&quot;callback_next&quot;:&quot;&quot;,&quot;manage_history&quot;:&quot;enabled&quot;,&quot;has_controls_in_form&quot;:&quot;disabled&quot;,&quot;infinite_tolerance&quot;:&quot;0&quot;,&quot;max_pages&quot;:1,&quot;page&quot;:1,&quot;base_permalink&quot;:&quot;\/eeb-lloydsmith\/wp-json\/wp\/v2\/pages\/18?wpv_view_count=71&amp;wpv_paged=WPV_PAGE_NUM&quot;,&quot;loop&quot;:{&quot;type&quot;:&quot;&quot;,&quot;name&quot;:&quot;&quot;,&quot;data&quot;:[],&quot;id&quot;:0}}\" data-permalink=\"\/eeb-lloydsmith\/wp-json\/wp\/v2\/pages\/18?wpv_view_count=71\">\n\n\t\n\t\n\t\t\n          <h6>NATURE ARTICLE ON H5N1 AVIAN FLU IN MAMMALS<\/h6>\n\n          <p>Jamie joined an international team to review curent knowledge on the global H5N1 influenza pandemic in mammals, published in <a href=\"https:\/\/www.nature.com\/articles\/s41586-024-08054-z\" target=\"_blank\">Nature<\/a>.<\/p>\n\n        \n\t\t\n          <h6>CELINE GRADUATES WITH HER PHD!<\/h6>\n\n          <p>Celine has filed her PhD!  Congratulations Dr. Snedden!!<\/p>\n\n        \n\t\t\n          <h6>WELCOME TO KRISTIE AND ERIKA<\/h6>\n\n          <p>Kristie Schott and Erika Ono-Kerns have joined the lab.  Welcome!!<\/p>\n\n        \n\t\t\n          <h6>PNAS ARTICLE ON HISTORICAL DISEASE SPREAD<\/h6>\n\n          <p>Lizzie&#8217;s paper on how viruses crossed oceans before the age of air travel, <a href=\"https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.2417598121\">published in PNAS<\/a>!<\/p>\n\n        \n\t\t\n          <h6>NEJM ARTICLE ON H5N1 IN MILK<\/h6>\n\n          <p>Dylan and Jamie join colleagues at the NIH to publish evidence for the effectiveness of heat treatment to inactivate H5N1 influenza in milk, published in the <a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMc2405488\" target=\"_blank\">New England Journal of Medicine<\/a>.<\/p>\n\n        \n\t\t\n          <h6>JAMIE APPOINTED TO LANCET COMMISSION<\/h6>\n\n          <p>Jamie is appointed to the <a href=\"https:\/\/www.preventingfuturepandemics.org\/commission\" target=\"_blank\">Lancet\/PPATS Commission on Prevention of Viral Spillover<\/a>, where he will co-lead the Scientific Evidence Working Group.  See the Commission announcement in <a href=\"https:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(23)01064-4\" target=\"_blank\">The Lancet<\/a> here.<\/p>\n\n        \n\t\t\n\t\n\t\n\t\n<\/div>\n\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-mglc6cm8-9c1a9cf7769e3f76ca78bdf869b33911 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Click <a href=\"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/news-archive\/\">here<\/a> to read more lab news.<\/p>\n<\/div><\/section><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":28,"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":543,"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/pages\/18\/revisions\/543"}],"wp:attachment":[{"href":"https:\/\/sites.lifesci.ucla.edu\/eeb-lloydsmith\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}