{"id":20,"date":"2017-02-09T22:42:29","date_gmt":"2017-02-10T06:42:29","guid":{"rendered":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/?page_id=20"},"modified":"2023-10-11T09:56:43","modified_gmt":"2023-10-11T16:56:43","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/","title":{"rendered":"Research"},"content":{"rendered":"<p>Our lab is broadly interested in understanding how reproductive hormones affect temperature and energy balance. The menopausal transition is associated with hot flashes and increased visceral body fat. Our research aims to understand how estrogens act on the hypothalamus to alter temperature homeostasis and\u00a0metabolic health. These studies can help us better understand the weight gain and hot flashes that people can experience during\u00a0the menopausal transition.<\/p>\n<p>To understand the mechanisms by which estrogen alters homeostasis, we focus on the following broad questions: How does the brain regulate temperature and energy balance? How are homeostatic neural circuits modulated by sex variables? How are homeostatic circuits modulated by changes in estrogen signaling?<\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2021\/01\/Screen-Shot-2021-01-26-at-11.10.54-AM.png\"><img loading=\"lazy\" decoding=\"async\" class=\"\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2021\/01\/Screen-Shot-2021-01-26-at-11.10.54-AM-300x216.png\" alt=\"\" width=\"372\" height=\"267\" \/><\/a><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/Mouse-eating-e1486422651171.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-9\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/Mouse-eating-e1486422651171-225x300.jpg\" alt=\"\" width=\"202\" height=\"270\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/Mouse-eating-e1486422651171-225x300.jpg 225w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/Mouse-eating-e1486422651171-768x1024.jpg 768w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/Mouse-eating-e1486422651171-720x960.jpg 720w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/Mouse-eating-e1486422651171-624x832.jpg 624w\" sizes=\"auto, (max-width: 202px) 100vw, 202px\" \/><\/a><\/p>\n<p><span class=\"s1\">Our approach integrates\u00a0molecular profiling, viral tools, and genetically engineered mice\u00a0to define the neurons and genes critical for maintaining temperature and energy balance.\u00a0This approach allows us to dissect the effects of estrogen on distinct neuronal populations with spatial, molecular, and temporal specificity.\u00a0<\/span><span class=\"s1\">Current studies focus on hypothalamic neurons that express e<\/span><span class=\"s1\">strogen receptor alpha (<span style=\"color: #00ff00\">green<\/span>).<\/span><\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-53 size-large\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH-960x581.jpg\" width=\"584\" height=\"353\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH-960x581.jpg 960w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH-300x182.jpg 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH-768x465.jpg 768w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH-496x300.jpg 496w, https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-content\/uploads\/sites\/59\/2017\/02\/ERa-in-MBH.jpg 1039w\" sizes=\"auto, (max-width: 584px) 100vw, 584px\" \/><\/a><\/p>\n<p>We have active collaborations with the labs of:<\/p>\n<p>Dr. Ed van Veen, UCLA (<a href=\"https:\/\/www.ibp.ucla.edu\/faculty\/ed-van-veen\/\">faculty page<\/a>, <a href=\"https:\/\/jevanveen.github.io\/\">lab website<\/a>)<\/p>\n<p>Dr. Annegret Falkner, Princeton (<a href=\"https:\/\/www.falknerlab.com\">lab website<\/a>)<\/p>\n<p>Dr. Avi Adhikari, UCLA (<a href=\"https:\/\/adhikarilab.psych.ucla.edu\">lab website<\/a>)<\/p>\n<p>Dr. Weizhe Hong, UCLA (<a href=\"https:\/\/www.hong-lab.org\">lab website<\/a>)<\/p>\n<p>Dr. Olu Ajijola, UCLA (<a href=\"https:\/\/ajijolalab.dgsom.ucla.edu\/pages\/\">lab website<\/a>)<\/p>\n<p>Dr. Fernando Gomez-Pinilla (<a href=\"https:\/\/www.uclahealth.org\/departments\/neurosurgery\/research\/research-scientists\/fernando-gomez-pinilla-phd\">faculty page<\/a>)<\/p>\n<p>Dr. Claudio Villanueva (<a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/\">lab website<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our lab is broadly interested in understanding how reproductive hormones affect temperature and energy balance. The menopausal transition is associated with hot flashes and increased visceral body fat. Our research aims to understand how estrogens act on the hypothalamus to alter temperature homeostasis and\u00a0metabolic health. These studies can help us better understand the weight gain [&hellip;]<\/p>\n","protected":false},"author":86,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/pages\/20","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/users\/86"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":29,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"predecessor-version":[{"id":851,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/pages\/20\/revisions\/851"}],"wp:attachment":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-correalab\/wp-json\/wp\/v2\/media?parent=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}