{"id":29,"date":"2020-05-20T21:22:19","date_gmt":"2020-05-20T21:22:19","guid":{"rendered":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/?page_id=29"},"modified":"2024-12-12T19:00:15","modified_gmt":"2024-12-12T19:00:15","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div id='full_slider_1'  class='avia-fullwidth-slider main_color avia-shadow   avia-builder-el-0  el_before_av_textblock  avia-builder-el-first   container_wrap fullsize'  ><div  class='avia-slideshow av-karfdgtn-0d21342b72fb409c2a62313779269365 avia-slideshow-featured av_slideshow_full avia-slide-slider av-slideshow-ui av-control-hidden av-no-slider-navigation av-hide-nav-arrows av-slideshow-manual av-loop-once av-loop-manual-endless av-default-height-applied   avia-slideshow-1' data-slideshow-options=\"{&quot;animation&quot;:&quot;slide&quot;,&quot;autoplay&quot;:false,&quot;loop_autoplay&quot;:&quot;once&quot;,&quot;interval&quot;:5,&quot;loop_manual&quot;:&quot;manual-endless&quot;,&quot;autoplay_stopper&quot;:false,&quot;noNavigation&quot;:true,&quot;bg_slider&quot;:false,&quot;keep_padding&quot;:false,&quot;hoverpause&quot;:false,&quot;show_slide_delay&quot;:0}\"  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><ul class='avia-slideshow-inner ' style='padding-bottom: 28.666666666667%;'><li  class='avia-slideshow-slide av-karfdgtn-0d21342b72fb409c2a62313779269365__0  av-single-slide slide-1 slide-odd'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-893 avia-img-lazy-loading-not-893\"  src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2021\/04\/panorama-banner-1500x430.jpg\" width=\"1500\" height=\"430\" title='panorama banner' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><\/ul><\/div><\/div><div id='after_full_slider_1'  class='main_color av_default_container_wrap container_wrap fullsize'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-full alpha units'><div class='post-entry post-entry-type-page post-entry-29'><div class='entry-content-wrapper clearfix'>\n<section  class='av_textblock_section av-kaih3uf4-41b7e380db4c193227a2abd64db3b7c8 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: center\"><span style=\"font-size: large\">&#8220;The central focus of my laboratory is to understand the neural control of visual, olfactory, and multisensory behavior. We study the fruit fly Drosophila to leverage techniques in neurogenetics, systems identification, &#8216;virtual reality&#8217; behavior, and <em>in-vivo\u00a0<\/em>imaging&#8221;<\/span><\/p>\n<\/div><\/section>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-aloj5-8bd10998cf5494fdf77fa55cfc842095\">\n.flex_column.av-aloj5-8bd10998cf5494fdf77fa55cfc842095{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-aloj5-8bd10998cf5494fdf77fa55cfc842095 av_one_half  avia-builder-el-2  el_after_av_textblock  el_before_av_one_half  first flex_column_div av-zero-column-padding  column-top-margin'     ><div  class='avia-video av-kaih1s7n-6fe27ddffa3688501abebd8dba91af3d avia-video-16-9 av-no-preview-image avia-video-load-always av-lazyload-immediate av-lazyload-video-embed'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/youtu.be\/iCs0KsEwC8E'><script type='text\/html' class='av-video-tmpl'><div class='avia-iframe-wrap'><iframe loading=\"lazy\" title=\"Innovations in the Life Sciences: Mark Frye\" width=\"1500\" height=\"844\" src=\"https:\/\/www.youtube.com\/embed\/iCs0KsEwC8E?feature=oembed&autoplay=0&loop=0&controls=1&mute=0\" frameborder=\"0\" allow=\"accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe><\/div><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-9qnxx-65a76eba614591013ee91b17d4e02c99\">\n.flex_column.av-9qnxx-65a76eba614591013ee91b17d4e02c99{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-9qnxx-65a76eba614591013ee91b17d4e02c99 av_one_half  avia-builder-el-4  el_after_av_one_half  el_before_av_hr  flex_column_div av-zero-column-padding  column-top-margin'     ><style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kaih2jmg-a65d6dbaaafde99c1511a9190b6e39b1\">\n.avia-video.av-kaih2jmg-a65d6dbaaafde99c1511a9190b6e39b1{\nbackground-image:url(https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2021\/01\/GAtech-300x169.jpg);\n}\n<\/style>\n<div  class='avia-video av-kaih2jmg-a65d6dbaaafde99c1511a9190b6e39b1 avia-video-16-9 av-preview-image avia-video-load-always av-lazyload-immediate av-lazyload-video-embed'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/mediaspace.gatech.edu\/media\/How+a+Fly+Sees+the+WorldA+Optogenetics%2C+Systems+ID%2C+and+Optophysiology+of+Visual+Flight+Control+in+Drosophila+-+Mark+Frye\/1_qjvraq3d'><script type='text\/html' class='av-video-tmpl'><a href=\"https:\/\/mediaspace.gatech.edu\/media\/How+a+Fly+Sees+the+WorldA+Optogenetics%2C+Systems+ID%2C+and+Optophysiology+of+Visual+Flight+Control+in+Drosophila+-+Mark+Frye\/1_qjvraq3d\">https:\/\/mediaspace.gatech.edu\/media\/How+a+Fly+Sees+the+WorldA+Optogenetics%2C+Systems+ID%2C+and+Optophysiology+of+Visual+Flight+Control+in+Drosophila+-+Mark+Frye\/1_qjvraq3d<\/a><\/script><div class='av-click-to-play-overlay'><div class=\"avia_playpause_icon\"><\/div><\/div><\/div><\/div>\n<div  class='hr av-9aqhh-04b4afc67705b4b26a57140bf93a5910 hr-default  avia-builder-el-6  el_after_av_one_half  el_before_av_textblock '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n<section  class='av_textblock_section av-kaihc0su-e1c759c2a69c49c42504744c9acb515e '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: center\"><span style=\"font-family: arial, helvetica, sans-serif\"><span style=\"font-size: 14pt\">THE PROBLEM<\/span><\/span><\/p>\n<p style=\"text-align: left\"><span style=\"font-family: arial, helvetica, sans-serif\">Right now your brain is processing massive amounts of information about your surroundings \u2013 colors, shapes, smells, sounds \u2013 to determine what is worthy of your attention. Perception is so automatic that you don\u2019t need to think about it. It is intuitive and unconscious. Yet the most sophisticated human-engineered systems can\u2019t do it. What if we could understand exactly how the brain processes reality within individual cells? That knowledge could be used to enable science fiction-style breakthroughs like prosthetic limbs that converse with the brain, or search robots that smell as well as a bloodhound, or an implantable chip that repairs blindness. The first step toward these transformative inventions is to \u2018reverse-engineer\u2019 the neural technology that evolution has honed over billions of years.<\/span><\/p>\n<p style=\"text-align: center\"><span style=\"font-family: arial, helvetica, sans-serif\"><span style=\"font-size: 14pt\">THE APPROACH<\/span><\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif\">Research in the Frye lab is shedding light on the brain\u2019s astonishing skills of perception. Combining tools from biology and engineering, like genetics, brain imaging and virtual reality simulators for fruit flies, the lab is investigating how the brain perceives the world\u00a0<em>while it\u2019s doing it<\/em>. Why fruit flies? Well, those little bugs that eat your old bananas actually perceive the world much in the same way humans do. Yet their brains have orders of magnitude fewer cells than ours, and scientists have invented ways to precisely control the genes and molecules underlying brain function. The lab&#8217;s research is unique in that they are monitoring the brain while the fly actively perceives its environment in real time. They can watch neurons fire in response to, say, a new smell or the movement of an object in the animal\u2019s visual field, and then directly connect the cellular response to changes in the animal\u2019s attention. In doing so, he is discovering the cellular building blocks of perception.<\/span><\/p>\n<p><span style=\"font-family: arial, helvetica, sans-serif\">by Emily Rose, Senior Strategy Officer, UCLA Health Sciences Development<\/span><\/p>\n<\/div><\/section>\n<div  class='hr av-1lall-549fa8de09dc608e462af50440ff3fc4 hr-default  avia-builder-el-8  el_after_av_textblock  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1lddl-10a0345b4850c8c1d21bbbe38047d263\">\n#top .av-special-heading.av-1lddl-10a0345b4850c8c1d21bbbe38047d263{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-1lddl-10a0345b4850c8c1d21bbbe38047d263 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-1lddl-10a0345b4850c8c1d21bbbe38047d263 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading 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id=\"style-css-av-67tcp-65f718c051c9abc49ddd6f52fc5331df\">\n.flex_column.av-67tcp-65f718c051c9abc49ddd6f52fc5331df{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-67tcp-65f718c051c9abc49ddd6f52fc5331df av_one_half  avia-builder-el-17  el_after_av_hr  el_before_av_one_half  first flex_column_div av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-28pyp-1f14051b7796c45dcb480015b57d8499\">\n#top .av-special-heading.av-28pyp-1f14051b7796c45dcb480015b57d8499{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-28pyp-1f14051b7796c45dcb480015b57d8499 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-28pyp-1f14051b7796c45dcb480015b57d8499 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-28pyp-1f14051b7796c45dcb480015b57d8499 av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-18  el_before_av_video  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >VISUAL FIXATION<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<div  class='avia-video av-5qs5p-bedf969812b7577b79998862f3be0c7f avia-video-16-9 av-no-preview-image avia-video-load-always avia-video-html5'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/ultimate_flight_arena_demo_728.mp4'><video class='avia_video' poster=\"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/ultimate_flight_arena_demo_728.jpg\"   preload=\"auto\"  controls id='player_29_321088586_1657746601'><source src='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/ultimate_flight_arena_demo_728.mp4' type='video\/mp4' 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src='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/jeans_fig-gnd_tracking_in_magno_168.mp4' type='video\/mp4' \/><\/video><\/div><\/p><\/div>\n<div  class='hr av-41ogt-780d28ed6ffa25f7d5dc02047f2e3852 hr-default  avia-builder-el-23  el_after_av_one_half  el_before_av_one_third '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-39n4p-5b9d3c08cd9625be30ea8c1c0f243f8b\">\n.flex_column.av-39n4p-5b9d3c08cd9625be30ea8c1c0f243f8b{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-39n4p-5b9d3c08cd9625be30ea8c1c0f243f8b av_one_third  avia-builder-el-24  el_after_av_hr  el_before_av_one_third  first flex_column_div av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-kaiha2p6-7fa988dcc06c70dc9dd9aca88b2f950e\">\n#top .av-special-heading.av-kaiha2p6-7fa988dcc06c70dc9dd9aca88b2f950e{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-kaiha2p6-7fa988dcc06c70dc9dd9aca88b2f950e .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-kaiha2p6-7fa988dcc06c70dc9dd9aca88b2f950e .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-kaiha2p6-7fa988dcc06c70dc9dd9aca88b2f950e av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-25  el_before_av_video  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >WALKING OPTOMOTOR BEHAVIOR<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<div  class='avia-video av-kaihay8m-9413db7f4eaa56399a79796560f44028 avia-video-16-9 av-no-preview-image avia-video-load-always avia-video-html5'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  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itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/acv_traj_bw_775.mp4'><video class='avia_video' poster=\"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/acv_traj_bw_775.jpg\"   preload=\"auto\"  controls id='player_29_1584650523_706472479'><source src='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/acv_traj_bw_775.mp4' type='video\/mp4' \/><\/video><\/div><\/p><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-20rxh-0e0ae0774643f69468ab91bce3b80397\">\n.flex_column.av-20rxh-0e0ae0774643f69468ab91bce3b80397{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-20rxh-0e0ae0774643f69468ab91bce3b80397 av_one_third  avia-builder-el-30  el_after_av_one_third  el_before_av_hr  flex_column_div 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av-no-preview-image avia-video-load-always avia-video-html5'  itemprop=\"video\" itemtype=\"https:\/\/schema.org\/VideoObject\"  data-original_url='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/vis_odor_941.mp4'><video class='avia_video' poster=\"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/vis_odor_941.jpg\"   preload=\"auto\"  controls id='player_29_890895442_1752152216'><source src='https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-content\/uploads\/sites\/19\/2020\/05\/vis_odor_941.mp4' type='video\/mp4' \/><\/video><\/div><\/p><\/div>\n<div  class='hr av-1008p-4107d5a1ba30a0118b7c35f98e53c9af hr-default  avia-builder-el-33  el_after_av_one_third  el_before_av_heading '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-15b4x-066522d99618eb6f7e0b91e24df0e7cf\">\n#top .av-special-heading.av-15b4x-066522d99618eb6f7e0b91e24df0e7cf{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-15b4x-066522d99618eb6f7e0b91e24df0e7cf .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-15b4x-066522d99618eb6f7e0b91e24df0e7cf .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-15b4x-066522d99618eb6f7e0b91e24df0e7cf av-special-heading-h3 blockquote modern-quote modern-centered  avia-builder-el-34  el_after_av_hr  el_before_av_textblock  av-linked-heading'><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >FUNDING<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div>\n<section  class='av_textblock_section av-kaihdbzn-556f119b8f5ccf4640a52c234ea8e862 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p>Our work has been supported by grants from the following:<br \/>\n<a href=\"https:\/\/www.nih.gov\/\">National Institutes of Health<\/a>, <a href=\"https:\/\/medschool.ucla.edu\/\">David Geffen School of Medicine<\/a>,\u00a0<a href=\"http:\/\/www.hhmi.org\/news\/ecs20090326.html\">The Howard Hughes Medical Institute\u00a0<\/a>,\u00a0<a href=\"http:\/\/www.nsf.gov\/\">The National Science Foundation\u00a0<\/a>,\u00a0<a href=\"http:\/\/www.wpafb.af.mil\/afrl\/afosr\/\">The US Air Force Office of Scientific Research<\/a>,\u00a0<a href=\"http:\/\/www.arl.army.mil\/www\/default.cfm?page=29\" target=\"_blank\" rel=\"noopener\">US Army Research Office,<\/a>\u00a0<a href=\"http:\/\/www.whitehall.org\/\">The Whitehall Foundation<\/a>,\u00a0<a href=\"https:\/\/sloan.org\/\">The Alfred P. Sloan Foundation<\/a>, the\u00a0<a href=\"http:\/\/www.wmkeck.org\/\">W.M. Keck Foundation<\/a>, and the\u00a0<a href=\"https:\/\/www.senate.ucla.edu\/committee\/cor\">UCLA\u00a0Council on Research<\/a><\/p>\n<\/div><\/section>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":664,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-29","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/users\/664"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":44,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":1893,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/pages\/29\/revisions\/1893"}],"wp:attachment":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-frye\/wp-json\/wp\/v2\/media?parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}