{"id":1138,"date":"2021-09-29T11:00:28","date_gmt":"2021-09-29T18:00:28","guid":{"rendered":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/?page_id=1138"},"modified":"2021-12-23T23:06:43","modified_gmt":"2021-12-24T07:06:43","slug":"neurodegeneration","status":"publish","type":"page","link":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/neurodegeneration\/","title":{"rendered":"Neurodegeneration"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1633152986002{margin-right: 1px !important;margin-bottom: 2px !important;margin-left: 1px !important;border-right-width: 2px !important;border-left-width: 2px !important;padding-top: 2px !important;padding-right: 20px !important;padding-bottom: 2px !important;padding-left: 20px !important;background-color: #ffffff !important;border-left-color: #dd3333 !important;border-left-style: outset !important;border-right-color: #dd3333 !important;border-right-style: outset !important;border-radius: 20px !important;}&#8221;]<\/p>\n<p style=\"text-align: justify\"><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1142 size-medium\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-269x300.png\" alt=\"\" width=\"269\" height=\"300\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-269x300.png 269w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-918x1024.png 918w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-768x857.png 768w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-1377x1536.png 1377w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-1836x2048.png 1836w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/Neurodegeneration-1200x1339.png 1200w\" sizes=\"auto, (max-width: 269px) 85vw, 269px\" \/><\/a><\/p>\n<p style=\"font-size: 20px;font-family: Montserrat;color: black;text-align: justify\">Our ongoing research seeks to clarify the basis for disease resilience and vulnerability by discovering the feedback loops between neural excitability, neuroinflammation and cellular metabolic stress in neurodegeneration at cellular and circuit levels. Our unique approach uses a combination of transgenic mouse models, mathematical modeling, open and closed-loop electrophysiology, molecular imaging and cell cultures to address this challenge. Given the positive societal impact this research can have on human health and well-being, we passionately pursue this expedition against all odds!! <a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/the-brain-and-its-diseases\/\">Read more<\/a>.<\/p>\n<p style=\"font-size: 20px;font-family: Montserrat;color: black;text-align: justify\">Some of our recent reports include (For a full list of our published work, click <a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/publications\/\" rel=\"noopener\">here<\/a>):<\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-1237 size-medium\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-300x288.png\" alt=\"\" width=\"300\" height=\"288\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-300x288.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-1024x982.png 1024w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-768x737.png 768w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-1536x1473.png 1536w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-2048x1965.png 2048w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/12\/GABApapersummary-e1640329422920-1200x1151.png 1200w\" sizes=\"auto, (max-width: 300px) 85vw, 300px\" \/><\/a><\/p>\n<p style=\"font-size: 20px;font-family: Montserrat;color: black;text-align: justify\">Pre-synaptic and ambient GABA deficiencies in the SOD1G93A ALS mouse and more (Preprint) <a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2021.12.16.473041v1\" target=\"_blank\" rel=\"noopener\">bioRXiv<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1144 size-medium alignleft\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919-293x300.png\" alt=\"\" width=\"293\" height=\"300\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919-293x300.png 293w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919-999x1024.png 999w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919-768x787.png 768w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919-1498x1536.png 1498w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919-1200x1230.png 1200w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/ND-paper-e1632944449919.png 1827w\" sizes=\"auto, (max-width: 293px) 85vw, 293px\" \/><\/a><\/p>\n<p style=\"font-size: 20px;font-family: Montserrat;color: black;text-align: justify\">Perturbed Cell Types and Pathways of Amyotrophic Lateral Sclerosis (2020) <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32360664\/\" target=\"_blank\" rel=\"noopener\">PMID: 32360664<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2019\/12\/CircuitSpecific.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-642 size-medium\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2019\/12\/CircuitSpecific-300x258.png\" alt=\"\" width=\"300\" height=\"258\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2019\/12\/CircuitSpecific-300x258.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2019\/12\/CircuitSpecific.png 649w\" sizes=\"auto, (max-width: 300px) 85vw, 300px\" \/><\/a><\/p>\n<p style=\"font-size: 20px;font-family: Montserrat;color: black;text-align: justify\">Stretch Reflex Circuit and Sodium Channel Abnormalities in Amyotrophic Lateral Sclerosis (2019) \u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31530644\" target=\"_blank\" rel=\"noopener\">PMID: 31530644<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/dynamicrange.png\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1147 size-medium alignleft\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/dynamicrange-300x255.png\" alt=\"\" width=\"300\" height=\"255\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/dynamicrange-300x255.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-content\/uploads\/sites\/38\/2021\/09\/dynamicrange.png 652w\" sizes=\"auto, (max-width: 300px) 85vw, 300px\" \/><\/a><\/p>\n<p style=\"font-size: 20px;font-family: Montserrat;color: black;text-align: justify\">Postnatal Deviance in Motor Neuron Excitability and Motor Pool Function in Amyotrophic Lateral Sclerosis (2015) <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25589764\" target=\"_blank\" rel=\"noopener\">PMID: 25589764<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;.vc_custom_1633152986002{margin-right: 1px !important;margin-bottom: 2px !important;margin-left: 1px !important;border-right-width: 2px !important;border-left-width: 2px !important;padding-top: 2px !important;padding-right: 20px !important;padding-bottom: 2px !important;padding-left: 20px !important;background-color: #ffffff !important;border-left-color: #dd3333 !important;border-left-style: outset !important;border-right-color: #dd3333 !important;border-right-style: outset !important;border-radius: 20px !important;}&#8221;] Our ongoing research seeks to clarify the basis for disease resilience and vulnerability by discovering the feedback loops between neural excitability, neuroinflammation and &hellip; <a href=\"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/neurodegeneration\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Neurodegeneration&#8221;<\/span><\/a><\/p>\n","protected":false},"author":57,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1138","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/pages\/1138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/users\/57"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/comments?post=1138"}],"version-history":[{"count":22,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/pages\/1138\/revisions"}],"predecessor-version":[{"id":1239,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/pages\/1138\/revisions\/1239"}],"wp:attachment":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-venugopal\/wp-json\/wp\/v2\/media?parent=1138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}