{"id":342,"date":"2023-08-16T14:42:07","date_gmt":"2023-08-16T21:42:07","guid":{"rendered":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/?page_id=342"},"modified":"2023-08-30T11:04:28","modified_gmt":"2023-08-30T18:04:28","slug":"homepage","status":"publish","type":"page","link":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/","title":{"rendered":"Homepage"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-anx92-80f03c162bb3480a5860a3a0a888246e\">\n.flex_column.av-anx92-80f03c162bb3480a5860a3a0a888246e{\npadding:0 200px 0 200px;\n}\n\n@media only screen and (min-width: 990px){ \n.flex_column.av-anx92-80f03c162bb3480a5860a3a0a888246e{\npadding:0 200px 0 200px;\n}\n}\n\n@media only screen and (min-width: 768px) and (max-width: 989px){ \n.flex_column.av-anx92-80f03c162bb3480a5860a3a0a888246e{\npadding:0 75px 0 75px;\n}\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n.flex_column.av-anx92-80f03c162bb3480a5860a3a0a888246e{\npadding:0 25px 0 25px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n.flex_column.av-anx92-80f03c162bb3480a5860a3a0a888246e{\npadding:0 20px 0 20px;\n}\n}\n<\/style>\n<div  class='flex_column av-anx92-80f03c162bb3480a5860a3a0a888246e av_one_full  avia-builder-el-0  el_before_av_one_full  avia-builder-el-first  first flex_column_div  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-1ig9q-6a1299b02dead88ee1d89e3479534d80\">\n#top .av-special-heading.av-1ig9q-6a1299b02dead88ee1d89e3479534d80{\npadding-bottom:10px;\n}\nbody .av-special-heading.av-1ig9q-6a1299b02dead88ee1d89e3479534d80 .av-special-heading-tag .heading-char{\nfont-size:25px;\n}\n.av-special-heading.av-1ig9q-6a1299b02dead88ee1d89e3479534d80 .av-subheading{\nfont-size:15px;\n}\n<\/style>\n<div  class='av-special-heading av-1ig9q-6a1299b02dead88ee1d89e3479534d80 av-special-heading-h3  avia-builder-el-1  el_before_av_textblock  avia-builder-el-first '><h3 class='av-special-heading-tag '  itemprop=\"headline\"  >Research<\/h3><div class=\"special-heading-border\"><div class=\"special-heading-inner-border\"><\/div><\/div><\/div><br \/>\n<section  class='av_textblock_section av-lle9qf6g-cfb59ae5ccdca7cce3c16d8341f83bab '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span style=\"font-size: 14pt\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-493 size-medium alignright\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Hero-e1692402326803-266x300.jpg\" alt=\"\" width=\"266\" height=\"300\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Hero-e1692402326803-266x300.jpg 266w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Hero-e1692402326803-913x1030.jpg 913w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Hero-e1692402326803-768x866.jpg 768w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Hero-e1692402326803-625x705.jpg 625w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Hero-e1692402326803.jpg 1000w\" sizes=\"auto, (max-width: 266px) 100vw, 266px\" \/>Welcome to our laboratory, where we embark on a quest to uncover the mysterious impact of signals released from adipocyte-lipolysi\u00ad\u00ads on triglyceride balance within the liver, programming adult stem cells, and fueling the flame of energy utilization. Our fascination lies in deciphering the molecular mechanisms that tip the scales between energy storage and energy expenditure\u2014a quest that holds the promise of revolutionary interventions to combat obesity, diabetes and fatty liver disease.<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lle9uysg-224cc3f06cb6aa9e3a85bf527200fe9a '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-492\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932-300x300.png\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932-300x300.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932-80x80.png 80w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932-36x36.png 36w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932-180x180.png 180w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932-705x705.png 705w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/lipids-1-e1692313527932.png 713w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/p>\n<p><span style=\"font-size: 14pt\"><strong>Unlocking Adipose-Liver Crosstalk: Unraveling the Secrets of Lipid Metabolism<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14pt\">Within the intricate web of our body&#8217;s energy management, the adipose tissue stands as the fortress of stored energy, ready to be unleashed through lipolysis to fuel other organ systems. This vital control over energy flow becomes the key to survival during extreme conditions like chilling cold or prolonged fasting. But the influence of adipocytes reaches beyond merely supplying energy; these dynamic cells wield the power to remotely regulate metabolism in distant tissues like the liver.<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lle9xeq9-1bc9bfeaefa659cdeafa776c087b6b90 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><span style=\"font-size: 14pt\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-347\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Lipid-Metabolism-300x300.png\" alt=\"\" width=\"200\" height=\"200\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Lipid-Metabolism-300x300.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Lipid-Metabolism-80x80.png 80w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Lipid-Metabolism-36x36.png 36w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Lipid-Metabolism-180x180.png 180w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/Lipid-Metabolism.png 420w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/>The Dance of Adipose Stem Cells: Bridging Obesity and Type 2 Diabetes<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14pt\">The adaptability of adipose tissue is paramount in orchestrating long-term energy harmony. By efficiently storing surplus energy, adipocytes prevent unwanted lipid overflow into organs such as muscles and the liver. This dynamic ebb and flow, governed by caloric influx, pivots on systems fostering ribosome biogenesis and translation, ensuring energy equilibrium. Our focus zeroes in on the role of translation in adipose progenitors and preadipocytes. How do these cells seamlessly weave together nutrient and hormonal signals to transition and differentiate?<\/span><\/p>\n<\/div><\/section><br \/>\n<section  class='av_textblock_section av-lle9x0z6-f37fd86ba2bf44eb56f62b9d05e81715 '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-348\" src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/mouse-Metabolic-Diseases-300x287.png\" alt=\"Mouse Metabolic Diseases\" width=\"200\" height=\"191\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/mouse-Metabolic-Diseases-300x287.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2023\/08\/mouse-Metabolic-Diseases.png 418w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/p>\n<p><span style=\"font-size: 14pt\"><strong>Fueling Thermogenic Adipocytes: A Novel Approach to Counter Metabolic Diseases<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14pt\">Meet the thermogenic adipocytes: the beige, brite, and brown variants. These cellular powerhouses transmute carbohydrates and fats into warmth by uncoupling the mitochondrial electron transport chain and activating futile cycles. Harnessing pathways that compel adipocytes to expend rather than conserve energy offers a promising avenue to fend off glucose intolerance. Our pioneering research has illuminated a transcriptional framework that accentuates thermogenesis, steering the metabolic scale towards energy liberation.<\/span><\/p>\n<p><span style=\"font-size: 14pt\">Dive in with us, as we journey through this exhilarating realm of cellular energy dynamics!<\/span><\/p>\n<\/div><\/section><\/p><\/div>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-897c6-6148819f3e2571e8d1e614424842c9d9\">\n.flex_column.av-897c6-6148819f3e2571e8d1e614424842c9d9{\npadding:0 200px 0 200px;\n}\n\n@media only screen and (min-width: 990px){ \n.flex_column.av-897c6-6148819f3e2571e8d1e614424842c9d9{\npadding:0 200px 0 200px;\n}\n}\n\n@media only screen and (min-width: 768px) and (max-width: 989px){ \n.flex_column.av-897c6-6148819f3e2571e8d1e614424842c9d9{\npadding:0 75px 0 75px;\n}\n}\n\n@media only screen and (min-width: 480px) and (max-width: 767px){ \n.flex_column.av-897c6-6148819f3e2571e8d1e614424842c9d9{\npadding:0 25px 0 25px;\n}\n}\n\n@media only screen and (max-width: 479px){ \n.flex_column.av-897c6-6148819f3e2571e8d1e614424842c9d9{\npadding:0 25px 0 25px;\n}\n}\n<\/style>\n<div  class='flex_column av-897c6-6148819f3e2571e8d1e614424842c9d9 av_one_full  avia-builder-el-6  el_after_av_one_full  avia-builder-el-last  first flex_column_div  column-top-margin'     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-lleacthq-80c21fb7365ad435e8fe1368f7444f63\">\n.avia-image-container.av-lleacthq-80c21fb7365ad435e8fe1368f7444f63 img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lleacthq-80c21fb7365ad435e8fe1368f7444f63 .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lleacthq-80c21fb7365ad435e8fe1368f7444f63 av-styling- av-img-linked avia-align-center  avia-builder-el-7  el_before_av_image  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/scholar.google.com\/citations?user=WHHb_MYAAAAJ&amp;hl=en\" class='avia_image '  target=\"_blank\"  rel=\"noopener noreferrer\" aria-label='Google_Scholar_logo'><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-96 avia-img-lazy-loading-not-96 avia_image ' src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/Google_Scholar_logo-300x50.png\" alt='' title='Google_Scholar_logo'  height=\"50\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/Google_Scholar_logo-300x50.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/Google_Scholar_logo-705x118.png 705w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/Google_Scholar_logo-450x76.png 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href=\"https:\/\/www.researchgate.net\/profile\/Claudio-Villanueva\" class='avia_image '  target=\"_blank\"  rel=\"noopener noreferrer\" aria-label='45e99a0d-f0ca-4b17-951a-ed0947f3fd0e-1510667426262'><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-97 avia-img-lazy-loading-not-97 avia_image ' src=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/45e99a0d-f0ca-4b17-951a-ed0947f3fd0e-1510667426262-300x158.png\" alt='' title='45e99a0d-f0ca-4b17-951a-ed0947f3fd0e-1510667426262'  height=\"158\" width=\"300\"  itemprop=\"thumbnailUrl\" srcset=\"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/45e99a0d-f0ca-4b17-951a-ed0947f3fd0e-1510667426262-300x158.png 300w, https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-content\/uploads\/sites\/224\/2019\/09\/45e99a0d-f0ca-4b17-951a-ed0947f3fd0e-1510667426262-768x403.png 768w, 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id=\"style-css-av-lleal05g-7dd1704e117ff01b0c045c9ec5bf898c\">\n.avia-image-container.av-lleal05g-7dd1704e117ff01b0c045c9ec5bf898c img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-lleal05g-7dd1704e117ff01b0c045c9ec5bf898c .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-lleal05g-7dd1704e117ff01b0c045c9ec5bf898c av-styling- av-img-linked avia-align-center  avia-builder-el-9  el_after_av_image  avia-builder-el-last '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><a href=\"https:\/\/twitter.com\/ClaudioVillanu\" class='avia_image '  target=\"_blank\"  rel=\"noopener noreferrer\" aria-label='twitter'><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-364 avia-img-lazy-loading-not-364 avia_image ' 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\/><\/a><\/div><\/div><\/div><\/p><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":742,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-342","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/pages\/342","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/users\/742"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/comments?post=342"}],"version-history":[{"count":39,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/pages\/342\/revisions"}],"predecessor-version":[{"id":520,"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/pages\/342\/revisions\/520"}],"wp:attachment":[{"href":"https:\/\/sites.lifesci.ucla.edu\/ibp-villanuevalab\/wp-json\/wp\/v2\/media?parent=342"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}