{"id":102,"date":"2023-12-12T19:11:55","date_gmt":"2023-12-13T03:11:55","guid":{"rendered":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/?page_id=102"},"modified":"2023-12-22T17:26:05","modified_gmt":"2023-12-23T01:26:05","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div id='full_slider_1'  class='avia-fullwidth-slider main_color avia-shadow   avia-builder-el-0  el_before_av_one_full  avia-builder-el-first   container_wrap sidebar_right'  ><div  class='avia-slideshow av-5bfq-2c99103f0eeb8898f61451f46fb0f109 avia-slideshow-featured av_slideshow_full avia-fade-slider av-slideshow-ui av-control-default av-slideshow-manual av-loop-once av-loop-manual-endless av-default-height-applied   avia-slideshow-1' data-slideshow-options=\"{&quot;animation&quot;:&quot;fade&quot;,&quot;autoplay&quot;:false,&quot;loop_autoplay&quot;:&quot;once&quot;,&quot;interval&quot;:5,&quot;loop_manual&quot;:&quot;manual-endless&quot;,&quot;autoplay_stopper&quot;:false,&quot;noNavigation&quot;:false,&quot;bg_slider&quot;:false,&quot;keep_padding&quot;:false,&quot;hoverpause&quot;:false,&quot;show_slide_delay&quot;:0}\"  itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><ul class='avia-slideshow-inner ' style='padding-bottom: 28.666666666667%;'><li  class='avia-slideshow-slide av-5bfq-2c99103f0eeb8898f61451f46fb0f109__0  av-single-slide slide-1 slide-odd'><div data-rel='slideshow-1' class='avia-slide-wrap '   ><div class='av-slideshow-caption av-5bfq-2c99103f0eeb8898f61451f46fb0f109__0 caption_fullwidth caption_bottom caption_bottom_framed caption_framed'><div class=\"container caption_container\"><div class=\"slideshow_caption\"><div class=\"slideshow_inner_caption\"><div class=\"slideshow_align_caption\"><h2 class='avia-caption-title '  itemprop=\"name\" >Research<\/h2><\/div><\/div><\/div><\/div><\/div><img decoding=\"async\" fetchpriority=\"high\" class=\"wp-image-643 avia-img-lazy-loading-not-643\"  src=\"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-content\/uploads\/sites\/315\/2023\/12\/Untitled-1500x430.jpg\" width=\"1500\" height=\"430\" title='Untitled' alt=''  itemprop=\"thumbnailUrl\"   \/><\/div><\/li><\/ul><\/div><\/div><div id='after_full_slider_1'  class='main_color av_default_container_wrap container_wrap sidebar_right'  ><div class='container av-section-cont-open' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-102'><div class='entry-content-wrapper clearfix'>\n<div  class='flex_column av-1lp8m-745d890fb98d4ecf3d1a07d3b58e7935 av_one_full  avia-builder-el-1  el_after_av_slideshow_full  avia-builder-el-no-sibling  first flex_column_div  '     ><section  class='av_textblock_section av-8zfli-3bdecfe03152f87d8d0ee5a1d022666a '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">Immune cells serve critical roles in maintaining organisms in a healthy state, interacting with both interlopers and internal targets.\u00a0 They eliminate infections by bacteria, viruses and parasites.\u00a0 Recent studies have shown that they also regulate processes of development, repair and regeneration, altering stem cell behavior and modulating metabolism. These functions depend on immune cells entering tissues, some during development to become tissue resident macrophages, such as microglia, and some in the adult in response to infection or damage, such as monocytes and neutrophils. Despite its importance, this is an extremely underexplored area.<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">We identify the cellular components and processes that regulate tissue invasion as a first step towards modulating this capacity.\u00a0 We particularly relish identifying unknown cellular pathways. Tuning infiltration up or down in a localized fashion could potentially decrease autoimmunity, improve immuno-oncological approaches to eliminate tumors, and increase regeneration and repair of damaged tissues.<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">We also explore our pathways\u2019 broader physiological relevance, including a new regulator of mitochondrial function, and other macrophage-tissue interactions.<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\"><strong>We ask:<\/strong><\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">1)\u00a0\u00a0\u00a0 In what ways does the tissue itself control infiltration?<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">2)\u00a0\u00a0\u00a0 What programs are required inside infiltrating cells for tissue invasion?<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">3)\u00a0\u00a0\u00a0 Do our pathways control other aspects of immune and neural function?<\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\"><strong>Approach:<\/strong><\/span><\/p>\n<p style=\"font-weight: 400\"><span style=\"font-size: 14pt\">We use a combination of diverse techniques (in vivo imaging, genetics including CRISPR\/Cas9 modification, cell biology, mass spectrometry, metabolomics, next generation sequencing, biophysics and modeling) to identify the mechanisms that underlie tissue invasion. We utilize Drosophila macrophages in the embryo as a model system to discover novel pathways, and extend our findings through collaborations to vertebrate models, including mouse, zebrafish, organoids and human cells.<\/span><\/p>\n<\/div><\/section><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1500,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-102","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/pages\/102","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/users\/1500"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/comments?post=102"}],"version-history":[{"count":13,"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/pages\/102\/revisions"}],"predecessor-version":[{"id":672,"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/pages\/102\/revisions\/672"}],"wp:attachment":[{"href":"https:\/\/sites.lifesci.ucla.edu\/mcdb-siekhaus\/wp-json\/wp\/v2\/media?parent=102"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}