Neeper, S.A., Gómez-Pinilla, F., Choi, J. and Cotman, C.W., Excercise-induced increase in brain-derived neurotrophic factor in the rat brain, Nature, 373 (1995) 109.

Molteni, R., Barnard, J.R., Ying, Z., Roberts, C.K., and Gómez-Pinilla, F., A high-fat, refined-sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and cognitive function, Neuroscience, 112(4) (2002) 803-814.

Molteni, Ying, Z., and Gómez-Pinilla, F., Differential Effects of Acute and Chronic Exercise on Plasticity-related Genes in the Rat Hippocampus Revealed by Microarray,  Eur. J. Neurosci., 16(6) (2002) 1107-1124.

Gómez-Pinilla, F., Ying, Z., Roy, R.R., Molteni, R., and Edgerton, R., Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity, J. Neurosphysiol., 88(5) (2002) 2196-2206.

Vaynman, S., Ying, Z., and Gomez-Pinilla, F., Interplay between BDNF and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity, Neuroscience, 122 (2003) 647-657.

Ying, Z., Roy, R.R.,Edgerton, V.R., and Gómez-Pinilla, F., Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord, Brain Res., 987 (1) (2003) 93-99.

Molteni, Ying, Z., Vaynman, S, and Gómez-Pinilla, F., Voluntary physical activity compensates for the deleterious effects of a saturated-fat diet on behavioral and neuronal plasticity, Neuroscience, 123(2) (2004) 429-440.

Hutchinson, KJ., Gómez-Pinilla, F. Crowe, MJ., Ying, Z., and Basso, M., Three Exercise Paradigms Differentially Improve Recovery of Sensation after Moderate Spinal Cord Contusions in Rats, Brain, 127 (2004) 1403-1414.

Wu, A., Ying, Z, and Gómez-Pinilla, F.  The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition, Eur. J. Neurosci., 19(7) (2004) 1699-1707.

Griesbach, G.S., Hovda, D., Molteni, R., and Gomez-Pinilla, F., Voluntary Exercise Following Traumatic Brain Injury: BDNF Upregulation and Recovery Function, Neuroscience, 125(1) (2004) 129-139.

Molteni, R., Zheng, Q-J., Ying, Z., Chang, B., Gomez-Pinilla, F., and Twiss, JL.,   Voluntary Exercise Increases Axonal Regeneration from Sensory Neurons, Proc Natl Acad Sci U S A, 101(22) (2004):8473-8.

Wu, A., Ying, Z, and Gómez-Pinilla, F.  Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in rats, J. Neurotrauma, 21(10) (2004) 1457-1467.

Gómez-Pinilla, F., Ying, Z., Roy, R.R., Hudgson, J., and Edgerton, R.  Afferent input modulates .neurotrophins and neuroplasticity in the spinal cord, J. Neurophysiology, 92(6) (2004 3423-3432.

Vaynman, S., Ying, Z., and Gomez-Pinilla, F., BDNF mediates the efficacy of exercise on synaptic plasticity and cognition, Eur. J. Neurosci., 20(10) (2004) 2580-2590.

Vaynman, S. and Gomez-Pinilla, F., A “deficient environment” in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus, Exp. Neurology, 192 (2) (2005) 235-243

Ying, Z., Roy, R.R.,Edgerton, V.R., and Gómez-Pinilla, F., Exercise preserves levels of neurotrophins and synaptic plasticity following spinal cord injury, Exp. Neurology, 193 (2005) 411-419.

Vaynman, S. and Gomez-Pinilla, F., License to run:  The impact of exercise on functional plasticity in the intact and injured CNS using neurotrophins, Neurehabil Neural Repair, 19(4) (2005) 283-295.

Wu, A., Ying, Z, and Gómez-Pinilla, F.  Dietary curcumin counteracts the outcome of traumatic brain injury on synaptic plasticity and cognition by reducing oxidative stress, Exp.Neurol. 197 (2006) 309-317.

Vaynman, S., Ying, Z., and Gomez-Pinilla, F., Coupling energy metabolism with a mechanism to support BDNF-mediated synaptic plasticity, Neuroscience, 139(4) (2006) 1221-1234.

Ding, Q., Vaynman, S., Akhavan, M., Ying, Z., and Gomez-Pinilla, F., Insulin-like growth factor I interfaces with BDNF-mediated synaptic-plasticity to modulate aspects of exercise-induced cognitive function, Neuroscience, 140(3) (2006) 823-833.

Vaynman, S. and Gomez-Pinilla, F., Revenge of the “Sit”; How lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity, J. Neurosci. Res., 84(4) (2006) 699-715.

Dishman RK, Berthoud HR, Booth FW, Cotman CW, Edgerton VR, Fleshner MR,Gandevia SC, Gomez-Pinilla F, Greenwood BN, Hillman CH, Kramer AF, Levin BE, Moran TH, Russo-Neustadt AA, Salamone JD, Van Hoomissen JD, Wade CE, York DA,Zigmond MJ. Neurobiology of exercise. Obesity 14 (3) (2006) 345-356.

Ding, Q., Vaynman, S., Souda, P., Whitelegge, J.P., Gomez-Pinilla, F., Exercise affects energy metabolism and neural plasticity related proteins in the hippocampus revealed by proteomic analysis, Eur. J. Neurosci., 24(5) (2006) 1265-1276..

Guzman-Marin, R., Ying, Z., Suntsova, N., Methippara, M., Bashir1, T., Szymusiak1, R., Gomez-Pinilla, F., and McGinty, D., Suppression of hippocampal plasticity-related gene expression by sleep deprivation, J Physiol. (2006) 15;575(Pt 3):807-19.

Gómez-Pinilla F, Huie JR, Ying Z, Ferguson AR, Crown ED, Baumbauer KM, Edgerton VR, Grau JW. BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expression. Neuroscience. 148(4) (2007) 893-906.

Griesbach GS, Gomez-Pinilla F, Hovda DA. Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent. J Neurotrauma. 24(7) (2007) 1161-71.

Ghiani CA, Ying Z, de Vellis J, Gomez-Pinilla F. Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growth.  Glia. 55(9) (2007) 966-75.

Wu A, Ying Z, Gomez-Pinilla F. Omega –3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain Injury. J Neurotrauma. 24(10) (2007) 1587-95.

Chytrova G, Ying Z, Gomez-Pinilla F. Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma. Eur J Neurosci. 27(1) (2008) 1-11.

Gomez-Pinilla F. The influences of diet and exercise on mental health through hormesis. Ageing Res Rev. 7(1) (2008) 49-62.

Ying Z, Roy RR, Zhong H, Zdunowski S, Edgerton VR, Gomez-Pinilla F. BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats. Neuroscience. 155(4) (2008) 1070-8.

Wu A, Ying Z, Gomez-Pinilla F. Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition. Neuroscience. 155(3) (2008) 751-9.

Gómez-Pinilla F.  Brain foods: the effects of nutrients on brain function. Nature Rev Neurosci. 9(7) (2008) 568-78.

Gomez-Pinilla, F., Vaynman, S., Ying, Z., BDNF Functions as a Metabotrophin to Mediate the Effects of Exercise on Cognition, Eur J Neurosci. 28(11) (2008) 2278-87.

Sharma S, Zhuang Y, Ying Z, Wu A, Gomez-Pinilla F. Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma. Neuroscience. 161(4) (2009) 1037-44.

Chytrova G, Ying Z, Gomez-Pinilla F. Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems. Brain Res. 1341(2010)32-40.

Krityakiarana W, Espinosa-Jeffrey A, Ghiani CA, Zhao PM, Topaldjikian N, Gomez-Pinilla F, Yamaguchi M, Kotchabhakdi N, de Vellis J. Voluntary exercise increases oligodendrogenesis in spinal cord. Int J Neurosci. 2010, Apr;120(4):280-90. doi: 10.3109/00207450903222741. PubMed PMID: 20374076; PubMed Central PMCID: PMC2852894.

Wu A, Ying Z, Schubert D, Gomez-Pinilla F. Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma. Neurorehabil Neural Repair. 25(4) (2011) 332-42.

Wu A, Ying Z, Gomez-Pinilla F. The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma. J Neurotrauma. 28(10) (2011) 2113-22.

Gomez-Pinilla, F., Zhuan, Y, Ying, L., Fan G., Exercise regulates BDNF plasticity by engaging epigenetic mechanisms, Eur J. Neurosci., (2011) 33(3) 383-390.

Bhatia HS, Agrawal R, Sharma S, Huo YX, Ying Z, Gomez-Pinilla F. Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood. PLoS One. 6(12) (2012):e28451.

Gomez-Pinilla F, Nguyen TT. Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders. Nutr Neurosci.15(3) (2012)127-33.

Ying Z, Covalin A, Judy J, Gomez-Pinilla F. Hypothalamic stimulation enhances hippocampal BDNF plasticity in proportion to metabolic rate. Brain Stimul. 5(4) (2012) 642-6.

Agrawal R, Gomez-Pinilla F. ‘Metabolic syndrome’ in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition. J Physiol. 590(Pt 10) (2012) 2485-99.

Sharma S, Zhuang Y, Gomez-Pinilla F. High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour. Sci Rep. 2 (2012) 431.

Joseph MS, Ying Z, Zhuang Y, Zhong H, Wu A, Bhatia HS, Cruz R, Tillakaratne NJ, Roy RR, Edgerton VR, Gomez-Pinilla F. Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning. PLoS One. 7(7) (2012) e41288.

Ying Z, Feng C, Agrawal R, Zhuang Y, Gomez-Pinilla F. Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage. PLoS One.7(12) (2012) e52998.

Baruch K, Ron-Harel N, Gal H, Deczkowska A, Shifrut E, Ndifon W, Mirlas-Neisberg N, Cardon M, Vaknin I, Cahalon L, Berkutzki T, Mattson MP, Gomez-Pinilla F, Friedman N, Schwartz M. CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad  Sci U S A. 2013 Feb 5;110(6):2264-9. PubMed PMID: 23335631; PubMed Central PMCID: PMC3568380.

Wu A, Ying Z, Gomez-Pinilla F. Exercise facilitates the action of dietary DHA on functional recovery after brain trauma. Neuroscience. 2013 Sep 17;248:655-63. doi:PMID: 23811071

Gomez-Pinilla F, Hillman C.  The influence of exercise on cognitive abilities.  Compr Physiol. 2013 Jan;3(1):403-28. doi: 10.1002/cphy.c110063. PMID: 23720292

Tyagi E, Agrawal R, Zhuang Y, Abad C, Waschek JA, Gomez-Pinilla F. Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders. PLoS One. 2013;8(3):e57945. doi: 10.1371/journal.pone.0057945. PMID: 23483949

Agrawal R, Tyagi E, Vergnes L, Reue K, Gomez-Pinilla F. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Biochim Biophys Acta. 2013; pii: S0925-4439(13)00359-1. PMID: 24345766.

Gomez-Pinilla F, Tyagi E. Diet and cognition: interplay between cell metabolism and neuronal plasticity. Curr Opin Clin Nutr Metab Care. 2013;16(6):726-33. PMID: 24071781.

Wu A, Ying Z, Gomez-Pinilla F. Dietary Strategy to Repair Plasma Membrane After Brain Trauma: Implications for Plasticity and Cognition. Neurorehabil Neural Repair. 2014; 28(1):75-84. PMID: 23911971.

Agrawal R, Tyagi E, Vergnes L, Reue K, Gomez-Pinilla F. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Biochim Biophys Acta. 2014 Apr;1842(4):535-46. PMID: 24345766 [PubMed – in process]

Tyagi E, Agrawal R, Ying Z, Gomez-Pinilla F. TBI and sex: crucial role of progesterone protecting the brain in an omega-3 deficient condition. Exp Neurol. 2014; 253:41-51.PMID: 24361060.

Agrawal R, Zhuang Y, Cummings BP, Stanhope KL, Graham JL, Havel PJ, Gomez-Pinilla F. Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. Biochim Biophys Acta. 2014;1842(9):1313-1323. PMID: 24840661

Tyagi, E, Zhuang, Y, Rahul Agrawal, R, ; Ying, Z, Gomez-Pinilla, F.; Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet, Neurobiology of Disease, 2015 Jan;73:307-18. doi: 10.1016/j.nbd.2014.09.014. Epub 2014 Oct 2. PMID: 25283985.

Wu A, Noble EE, Tyagi E, Ying Z, Zhuang Y, Gomez-Pinilla F.  Curcumin boosts DHA in the brain: implications for the prevention of anxiety disorders, Biochim Biophys Acta, 2015 May;1852(5):951-61. doi: 10.1016/j.bbadis.2014.12.005. Epub 2014 Dec 27.  PMID: 25550171.

Agrawal R, Noble E, Tyagi E, Zhuang Y, Ying Z, Gomez-Pinilla F. Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation. Biochim Biophys Acta. 2015 Feb 3;1852(5):862-872. doi: 10.1016/j.bbadis.2015.01.018. PMID: 25661191.

Agrawal R, Yumei Zhuang, Noble E, Vergnes L, Ying Z, Reue K and Gomez-Pinilla F, Dietary fructose aggravates the pathobiology of TBI by influencing energy homeostasis and plasticity, J. Cerebral Blood Flow Metab, 2015 Oct 1. PMID:  26661172

Cisternas P, Salazar P, Serrano FG, Montecinos-Oliva C, Arredondo SB, Varela-Nallar L, Barja S, Vio CP, Gomez-Pinilla F, Inestrosa NC.  Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance.  Biochim Biophys Acta. 2015 Nov;1852(11):2379-90. doi: 10.1016/j.bbadis.2015.08.016. PMID: 26300486

Thompson AB, Stolyarova A, Ying Z, Zhuang Y, Gómez-Pinilla F, Izquierdo A.  Neuropharmacology.  Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum. 2015 Dec;99:658-64. doi: 10.1016/j.neuropharm.2015.08.045. Epub 2015 Aug 31. PMID: 26334786

Yoon H, Kleven A, Paulsen A, Kleppe L, Wu J, Ying Z, Gomez-Pinilla F, Scarisbrick IA. Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system. Biochim Biophys Acta. 2016 Apr;1862(4):545-55. PubMed PMID: 26826016; PubMed Central PMCID: PMC4788558.

Krityakiarana W, Zhao PM, Nguyen K, Gomez-Pinilla F, Kotchabhakdi N, de Vellis J, Espinosa-Jeffrey A. Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res. 2016 Feb;41(1-2):431-49. doi: 10.1007/s11064-016-1850-z. Epub 2016 Feb 17. PubMed PMID: 26883642.

Gomes da Silva S, Victorino AB, de Almeida AA, Carvalho AD, Cabral FR, Gomez-Pinilla F, Arida RM. Neural Reserve Induced By Practice Of Physical Activity In Adolescence: A Study Of The Intracellular Signaling Pathways Linked To Cellular Growth And Proliferation: 3023 Board #88 June 3, 2: 00 PM – 3: 30 PM. Med Sci Sports Exerc. 2016 May;48(5 Suppl 1):854. PubMed PMID: 27361592.

Carlin JL, Grissom N, Ying Z, Gomez-Pinilla F, Reyes TM. Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex. Brain Behav Immun. 2016 Nov;58:82-90. doi: 10.1016/j.bbi.2016.07.161. PubMed PMID: 27492632.

Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, Zhang B, Pellegrini M, Xiao X, Young MF, Gomez-Pinilla F, Yang X. Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. EBioMedicine. 2016 May;7:157-66. PubMed PMID: 27322469; PubMed Central PMCID: PMC4909610.

Qingying Meng, Yumei Zhuang, Zhe Ying, Rahul Agrawal, Xia Yang, Fernando Gomez-Pinilla.  Traumatic Brain Injury Induces Genome-wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders , EBioMedicine, in press.