Recent Publications

2022

Editorial to special issue of BBADIS: Brain-gut interaction and cognitive control
Fernando Gomez-Pinilla, 2022 Jul

Diet and depression: future needs to unlock the potential
Wolfgang Marx, Melissa M Lane, Meghan Hockey, Hajara Aslam, Ken Walder, Alessandra Borsini, Joseph Firth, Carmine M Pariante, Kirsten Berding, John F Cryan, Gerard Clarke, Jeffrey M Craig, Kuan-Pin Su, David Mischoulon, Fernando Gomez-Pinilla, Jane A Foster, Patrice D Cani, Sandrine Thuret, Heidi M Staudacher, Almudena Sánchez-Villegas, Husnain Arshad, Tasnime Akbaraly, Adrienne O’Neil, Felice N Jacka, 2022 Feb

2021

Joint cell segmentation and cell type annotation for spatial transcriptomics
Russell Littman, Zachary Hemminger, Robert Foreman, Douglas Arneson, Guanglin Zhang, Fernando Gómez-Pinilla, Xia Yang, Roy Wollman, 2021 Jun

Dietary fructose as a model to explore the influence of peripheral metabolism on brain function and plasticity
Fernando Gomez-Pinilla, Rafael Parcianello Cipolat, Luiz Fernando Freire Royes, 2021 May

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
Yingxi Wu, Haijian Wu, Jianxiong Zeng, Brock Pluimer, Shirley Dong, Xiaochun Xie, Xinying Guo, Tenghuan Ge, Xinyan Liang, Sudi Feng, Youzhen Yan, Jian-Fu Chen, Naomi Sta Maria, Qingyi Ma, Fernando Gomez-Pinilla, Zhen Zhao, 2021 Apr

The interactions between brain and liver regulates lipid metabolism in the TBI pathology
Victoria Palafox-Sánchez , Zhe Ying, Luiz Fernando Freire Royes, Fernando Gomez-Pinilla, 2021 Apr

Diet and depression: exploring the biological mechanisms of action
Wolfgang Marx, Melissa Lane, Meghan Hockey, Hajara Aslam, Michael Berk, Ken Walder, Alessandra Borsini, Joseph Firth, Carmine M Pariante, Kirsten Berding, John F Cryan, Gerard Clarke, Jeffrey M Craig, Kuan-Pin Su, David Mischoulon, Fernando Gomez-Pinilla, Jane A Foster, Patrice D Cani, Sandrine Thuret, Heidi M Staudacher, Almudena Sánchez-Villegas, Husnain Arshad, Tasnime Akbaraly, Adrienne O’Neil, Toby Segasby, Felice N Jacka, 2021 Jan

2020

Multi-Tissue Multi-Omics Nutrigenomics Indicates Context-Specific Effects of Docosahexaenoic Acid on Rat Brain 
Guanglin Zhang, Qingying Meng, Montgomery Blencowe, Rahul Agrawal, Fernando Gomez-Pinilla, Xia Yang, 2020 Oct

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice
In Sook Ahn , Jennifer M Lang, Christine A Olson, Graciel Diamante, Guanglin Zhang, Zhe Ying, Hyae Ran Byun, Ingrid Cely, Jessica Ding, Peter Cohn, Ira Kurtz, Fernando Gomez-Pinilla, Aldons J Lusis, Elaine Y Hsiao, Xia Yang, 2020 Oct

Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease
Richard J Johnson, Fernando Gomez-Pinilla, Maria Nagel, Takahiko Nakagawa, Bernardo Rodriguez-Iturbe, Laura G Sanchez-Lozada, Dean R Tolan, Miguel A Lanaspa, 2020 Sep

Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice
Guanglin Zhang, Hyae Ran Byun, Zhe Ying, Montgomery Blencowe, Yuqi Zhao, Jason Hong, Le Shu, Karthick Chella Krishnan, Fernando Gomez-Pinilla, Xia Yang, 2020 Jan

2019

Early exercise induces long-lasting morphological changed in cortical and hippocampal neurons throughout of a sedentary period of rats
Fernando Tadeu Serra, Andrea Dominguez Carvalho, Bruno Henrique Silva Araujo, Laila Brito Torres, Fabrizio Dos Santos Cardoso, Jéssica Salles Henrique, Eduardo Varejão Díaz Placencia, Roberto Lent, Fernando Gomez-Pinilla, Ricardo Mario Arida, Sérgio Gomes da Silva, 2019 Sep

Blueberry Supplementation Mitigates Altered Brain Plasticity and Behavior after Traumatic Brain Injury in Rats
Gokul Krishna, Zhe Ying, Fernando Gomez-Pinilla, 2019 Aug

Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?
Shraddha D Rege, Luiz Royes, Brandon Tsai, Guanglin Zhang, Xia Yang, Fernando Gomez-Pinilla 2019, Aug

Making sense of gut feelings in the traumatic brain injury pathogenesis
Luiz Fernando Freire Royes, Fernando Gomez-Pinilla, 2029 Jul

2018

Nerve Growth Factor If Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function
Joseph M Hall, Fernando Gomez-Pinilla, Lisa M Savage, 2018 Nov

Single cell molecular alterations reveal target cells and pathways of concussive brain injury 
Douglas Arneson, Guanglin Zhang, Zhe Ying, Yumei Zhuang, Hyae Ran Byun, In Sook Ahn, Fernando Gomez-Pinilla, Xia Yang. Nature Comm, 2018. Accepted.

System Biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders
 Gomez-Pinilla F, Yang X. Prog Neurobiol. 2018 Jul 27. pii: S0301-0082(17)30125-9. Review.

Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome. Jiménez-Maldonado A, Ying Z, Byun HR, Gomez-Pinilla F. Biochim Biophys Acta. 2018 Jan;1864(1):24-33.

2017

Physical exercise as an epigenetic modulator of brain plasticity and cognition. Fernandes J, Arida RM, Gomez-Pinilla F. Neurosci Biobehav Rev. 2017 Sep;80:443-456.  Review.

7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery. Krishna G, Agrawal R, Zhuang Y, Ying Z, Paydar A, Harris NG, Royes LFF, Gomez-Pinilla F. Biochim Biophys Acta. 2017 Jun;1863(6):1204-1213.

Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids. Hakimian J, Minasyan A, Zhe-Ying L, Loureiro M, Beltrand A, Johnston C, Vorperian A, Romaneschi N, Atallah W, Gomez-Pinilla F, Walwyn W. PLoS One. 2017 Apr 5;12(4)

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. Meng Q, Zhuang Y, Ying Z, Agrawal R, Yang X, Gomez-Pinilla F. EBioMedicine. 2017 Feb;16:184-194.

Effects of melatonin on severe crush spinal cord injury-induced reactive astrocyte and scar formation. Krityakiarana W, Sompup K, Jongkamonwiwat N, Mukda S, Pinilla FG, Govitrapong P, Phansuwan-Pujito P. J Neurosci Res. 2016 Dec

Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex. Carlin JL, Grissom N, Ying Z, Gomez-Pinilla F, Reyes TM. Brain Behav Immun. 2016 Nov

Neural Reserve Induced By Practice Of Physical Activity In Adolescence: A Study Of The Intracellular Signaling Pathways Linked To Cellular Growth And Proliferation: 3023 Board #88 June 3, 2: 00 PM – 3: 30 PM. Gomes da Silva S, Victorino AB, de Almeida AA, Carvalho AD, Cabral FR, Gomez-Pinilla F, Arida RM. Med Sci Sports Exerc. 2016 May

Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders. Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, Zhang B, Pellegrini M, Xiao X, Young MF, Gomez-Pinilla F, Yang X. EBioMedicine. 2016 May

Erratum to: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Krityakiarana W, Zhao PM, Nguyen K, Gomez-Pinilla F, Kotchabhakdi N, de Vellis J, Espinosa-Jeffrey A. Neurochem Res. 2016 Jul

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Krityakiarana W, Zhao PM, Nguyen K, Gomez-Pinilla F, Kotchabhakdi N, de Vellis J, Espinosa-Jeffrey A. Neurochem Res. 2016 Feb

Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system. Yoon H, Kleven A, Paulsen A, Kleppe L, Wu J, Ying Z, Gomez-Pinilla F, Scarisbrick IA. Biochim Biophys Acta. 2016 Apr

Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity. Agrawal R, Noble E, Vergnes L, Ying Z, Reue K, Gomez-Pinilla F. J Cereb Blood Flow Metab. 2016 May

2015

Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum. Thompson AB, Stolyarova A, Ying Z, Zhuang Y, Gómez-Pinilla F, Izquierdo A. Neuropharmacology. 2015 Dec

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance. Cisternas P, Salazar P, Serrano FG, Montecinos-Oliva C, Arredondo SB, Varela-Nallar L, Barja S, Vio CP, Gomez-Pinilla F, Inestrosa NC. Biochim Biophys Acta. 2015 Nov

Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation. Agrawal R, Noble E, Tyagi E, Zhuang Y, Ying Z, Gomez-Pinilla F. Biochim Biophys Acta. 2015 May

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders. Wu A, Noble EE, Tyagi E, Ying Z, Zhuang Y, Gomez-Pinilla F. Biochim Biophys Acta. 2015 May

2014

Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes. Agrawal R, Zhuang Y, Cummings BP, Stanhope KL, Graham JL, Havel PJ, Gomez-Pinilla F. Biochim Biophys Acta. 2014 Sep

TBI and sex: crucial role of progesterone protecting the brain in an omega-3 deficient condition. Tyagi E, Agrawal R, Ying Z, Gomez-Pinilla F. Exp Neurol. 2014 Mar