The BDNF mimetic R-13 attenuates TBI pathogenesis using TrkB-related pathways and bioenergetics

Thapak P, Smith G, Ying Z, Paydar A, Harris N, Gomez-Pinilla F, 2023 Jun

Liver acts as a metabolic gate for the traumatic brain injury pathology: Protective action of thyroid hormone

Khandelwal M, Krishna G, Ying Z, Gomez-Pinilla F, 2023 May


How to boost the effects of exercise to favor traumatic brain injury outcome

Gomez-Pinilla F, Mercado N, 2022 Sep

Systems spatiotemporal dynamics of traumatic brain injury at single-cell resolution reveals humanin as a therapeutic target

Arneson D, Zhang G, Ahn I, Ying Z, Diamante G, Cely I, Palafox-Sanchez V, Gomez-Pinilla F, Yang X, 2022 Aug

Traumatic brain injury alters the gut-derived serotonergic system and associated peripheral organs

Mercado N, Zhang G, Ying Z, Gomez-Pinilla F, 2022 Jul

Editorial to special issue of BBADIS: Brain-gut interaction and cognitive control
Gomez-Pinilla F, 2022 Jul

Diet and depression: future needs to unlock the potential
Marx W, Lane M, Hockey M, Aslam H, Walder K, Borsini A, Firth J, Pariante C,  Berding K, Cryan J, Clarke G, Craig J, Su K, Mischoulon D, Gomez-Pinilla F, Foster J, Cani P, Thuret S, Staudacher H, Sánchez-Villegas A, Arshad H, Akbaraly T, O’Neil A, Jacka F, 2022 Feb


Joint cell segmentation and cell type annotation for spatial transcriptomics
Littman R, Hemminger Z, Foreman R, Arneson D, Zhang G, Gómez-Pinilla F, Yang X, Wollman R, 2021 Jun

Dietary fructose as a model to explore the influence of peripheral metabolism on brain function and plasticity
Gomez-Pinilla F, Cipolat R, Royes L, 2021 May

Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice
Wu Y, Wu H, Zeng J, Pluimer B, Dong S, Xie S, Guo X, Ge T, Liang X, Feng S, Yan Y, Chen J, Maria N, Ma Q, Gomez-Pinilla. F, Zhao Z, 2021 Apr

The interactions between brain and liver regulates lipid metabolism in the TBI pathology
Palafox-Sánchez V, Ying Z, Royes L, Gomez-Pinilla F, 2021 Apr

Diet and depression: exploring the biological mechanisms of action
Marx W, Lane M, Hockey M, Aslam H, Berk M, Walder K, Borsini A, Firth J, Pariante C, Berding K, Cryan J, Clarke G, Craig J, Su K, Mischoulon D, Gomez-Pinilla F, Foster J, Cani P, Thuret S, Staudacher H, Sánchez-Villegas A, Arshad H, Akbaraly T, O’Neil A, Segasby T, Jacka F, 2021 Jan


Multi-Tissue Multi-Omics Nutrigenomics Indicates Context-Specific Effects of Docosahexaenoic Acid on Rat Brain 
Zhang G, Meng Q, Blencowe M, Agrawal R, Gomez-Pinilla F, Yang X, 2020 Oct

Host Genetic Background and Gut Microbiota Contribute to Differential Metabolic Responses to Fructose Consumption in Mice
Ahn I, Lang J, Olson C, Diamante G, Zhang G, Ying Z, H Byun, Cely I, Ding J, Cohn P, Kurtz I, Gomez-Pinilla F, Lusis A, Hsiao E, Yang X, 2020 Oct

Cerebral Fructose Metabolism as a Potential Mechanism Driving Alzheimer’s Disease
Johnson R, Gomez-Pinilla F, Nagel M, Nakagawa T, Rodriguez-Iturbe b, Sanchez-Lozada L, Tolan D, Lanaspa M, 2020 Sep

Differential metabolic and multi-tissue transcriptomic responses to fructose consumption among genetically diverse mice
Zhang G, Byun H, Ying Z, Blencowe M, Zhao Y, Hong J, Shu L, Krishnan K, Gomez-Pinilla F, Yang X, 2020 Jan


Early exercise induces long-lasting morphological changed in cortical and hippocampal neurons throughout of a sedentary period of rats
Serra F, Carvalho A, Araujo B, Torres L, Cardoso F, Henrique J, PlacenciaRoberto Lent E, Gomez-Pinilla F, Arida R, Silva S, 2019 Sep

Blueberry Supplementation Mitigates Altered Brain Plasticity and Behavior after Traumatic Brain Injury in Rats
Krishna G, Ying Z, Gomez-Pinilla F, 2019 Aug

Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?
Rege S, Royes L, Tsai B, Zhang G, Yang X, Gomez-Pinilla F, 2019 Aug

Making sense of gut feelings in the traumatic brain injury pathogenesis
Royes L, Gomez-Pinilla F, 2019 Jul


Nerve Growth Factor If Responsible for Exercise-Induced Recovery of Septohippocampal Cholinergic Structure and Function
Hall J, Gomez-Pinilla F, Savage L, 2018 Nov

Single cell molecular alterations reveal target cells and pathways of concussive brain injury 
Arneson D, Zhang G, Ying Z, Zhuang Y, Byun H, Ahn I, Gomez-Pinilla F, Yang X, 2018 Sep

System Biology approach intersecting diet and cell metabolism with pathogenesis of brain disorders

Gomez-Pinilla F, Yang X, 2018 Jul

Short-term fructose ingestion affects the brain independently from establishment of metabolic syndrome.

Jiménez-Maldonado A, Ying Z, Byun HR, Gomez-Pinilla F, 2018 Jan


Physical exercise as an epigenetic modulator of brain plasticity and cognition. 

Fernandes J, Arida RM, Gomez-Pinilla F, 2017 Sep

7,8-Dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery. 

Krishna G, Agrawal R, Zhuang Y, Ying Z, Paydar A, Harris NG, Royes LFF, Gomez-Pinilla F, 2017 Jun

Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids. 

Hakimian J, Minasyan A, Zhe-Ying L, Loureiro M, Beltrand A, Johnston C, Vorperian A, Romaneschi N, Atallah W, Gomez-Pinilla F, Walwyn W, 2017 Apr

Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. 

Meng Q, Zhuang Y, Ying Z, Agrawal R, Yang X, Gomez-Pinilla F, 2017 Feb


Effects of melatonin on severe crush spinal cord injury-induced reactive astrocyte and scar formation.

Krityakiarana W, Sompup K, Jongkamonwiwat N, Mukda S, Pinilla FG, Govitrapong P, Phansuwan-Pujito P, 2016 Dec

Voluntary exercise blocks Western diet-induced gene expression of the chemokines CXCL10 and CCL2 in the prefrontal cortex.

Carlin JL, Grissom N, Ying Z, Gomez-Pinilla F, Reyes TM, 2016 Nov

Neural Reserve Induced By Practice Of Physical Activity In Adolescence: A Study Of The Intracellular Signaling Pathways Linked To Cellular Growth And Proliferation: 3023 Board #88 June 3, 2: 00 PM – 3: 30 PM.

Gomes da Silva S, Victorino AB, de Almeida AA, Carvalho AD, Cabral FR, Gomez-Pinilla F, Arida RM,  2016 May

Systems Nutrigenomics Reveals Brain Gene Networks Linking Metabolic and Brain Disorders.

Meng Q, Ying Z, Noble E, Zhao Y, Agrawal R, Mikhail A, Zhuang Y, Tyagi E, Zhang Q, Lee JH, Morselli M, Orozco L, Guo W, Kilts TM, Zhu J, Zhang B, Pellegrini M, Xiao X, Young MF, Gomez-Pinilla F, Yang X,  2016 May

Erratum to: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration.

Krityakiarana W, Zhao PM, Nguyen K, Gomez-Pinilla F, Kotchabhakdi N, de Vellis J, Espinosa-Jeffrey A, 2016 Jul

Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration.

Krityakiarana W, Zhao PM, Nguyen K, Gomez-Pinilla F, Kotchabhakdi N, de Vellis J, Espinosa-Jeffrey A, 2016 Feb

Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system.

Yoon H, Kleven A, Paulsen A, Kleppe L, Wu J, Ying Z, Gomez-Pinilla F, Scarisbrick IA, 2016 Apr

Dietary fructose aggravates the pathobiology of traumatic brain injury by influencing energy homeostasis and plasticity.

Agrawal R, Noble E, Vergnes L, Ying Z, Reue K, Gomez-Pinilla F, 2016 May


Methamphetamine blocks exercise effects on Bdnf and Drd2 gene expression in frontal cortex and striatum.

Thompson AB, Stolyarova A, Ying Z, Zhuang Y, Gómez-Pinilla F, Izquierdo A, 2015 Dec

Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance.

Cisternas P, Salazar P, Serrano FG, Montecinos-Oliva C, Arredondo SB, Varela-Nallar L, Barja S, Vio CP, Gomez-Pinilla F, Inestrosa NC, 2015 Nov

Flavonoid derivative 7,8-DHF attenuates TBI pathology via TrkB activation.

Agrawal R, Noble E, Tyagi E, Zhuang Y, Ying Z, Gomez-Pinilla F, 2015 May

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders.

Wu A, Noble EE, Tyagi E, Ying Z, Zhuang Y, Gomez-Pinilla F, 2015 May


Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes.

Agrawal R, Zhuang Y, Cummings BP, Stanhope KL, Graham JL, Havel PJ, Gomez-Pinilla F, 2014 Sep

Coupling energy homeostasis with a mechanism to support plasticity in brain trauma.

Agrawal R, Tyagi E, Vergnes L, Reue K, Gomez-Pinilla F, 2014 Apr

TBI and sex: crucial role of progesterone protecting the brain in an omega-3 deficient condition.

Tyagi E, Agrawal R, Ying Z, Gomez-Pinilla F, 2014 Mar


Diet and cognition: interplay between cell metabolism and neuronal plasticity.

Gomez-Pinilla F, Tyagi E, 2013 Nov

Exercise facilitates the action of dietary DHA on functional recovery after brain trauma.

Wu A, Ying Z, Gomez-Pinilla F, 2013 Sep

Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders.

Tyagi E, Agrawal R, Zhuang Y, Abad C, Waschek J, Gomez-Pinilla F, 2013 Mar

CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging.

Baruch K, Ron-Harel N, Gal H, Deczkowska A, Shifrut E, Ndifon W, Mirlas-Neisberg N, Cardon M, Vaknin I, Cahalon L, Berkutzki T, Mattson M, Gomez-Pinilla F, Friedman N, Schwartz M, 2013 Feb

The influence of exercise on cognitive abilities.

Gomez-Pinilla F, Hillman C


Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage.

Ying Z, Feng C, Agrawal R, Zhuang Y, Gomez-Pinilla F, 2012 Dec

Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders.

Gomez-Pinilla F, Nguyen T, 2012 May

High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour.

Sharma S, Zhuang Y, Gomez-Pinilla F, 2012 May

‘Metabolic syndrome’ in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signaling and cognition.

Agrawal R, Gomez-Pinilla F, 2012 May

Hypothalamic stimulation enhances hippocampal BDNF plasticity in proportion to metabolic rate.

Ying Z, Covalin A, Judy J, Gomez-Pinilla F, 2012 Feb

2011 & earlier

Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood.

Bhatia H, Agrawal R, Sharma S, Huo Y, Ying Z, Gomez-Pinilla F, 2011 Dec

The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma.

Wu A, Ying Z, Gomez-Pinilla F, 2011 Oct

Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma.

Wu A, Ying Z, Schubert D, Gomez-Pinilla F, 2011 Feb

Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation.

Gomez-Pinilla F, Zhuang Y, Feng J, Ying Z, Fan G, 2010 Dec

Exercise contributes to the effects of DHA dietary supplementation by action on membrane-related synaptic systems. 

Chytrova G, Ying Z, Gomez-Pinilla F, 2010 Jun

Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition.

Gomez-Pinilla F, Vaynman S, Ying Z, 2008 Dec

Brain foods: the effects of nutrients on brain function. 

Gomez-Pinilla F, 2008 Jul

Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury.

Wu A, Ying Z, Gomez-Pinilla F, 2007 Oct

Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis.

Ding Q, Vaynman S, Souda P, Whitelegge J, Gomez-Pinilla F, 2006 Sep

Revenge of the “sit”: how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity.

Vaynman S, Gomez-Pinilla F, 2006 Sep

Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition.

Wu A, Ying Z, Gomez-Pinilla F, 2006 Feb