Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res. 2023 Aug 26:100434. doi: 10.1016/j.jlr.2023.100434. Epub ahead of print. PMID: 37640283.

Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K.  Sci Adv. 2023 Feb 24;9(8):eade7864. doi: 10.1126/sciadv.ade7864. Epub 2023 Feb 24. PMID: 36827367; PMCID: PMC9956115.

Hepatic nonvesicular cholesterol transport is critical for systemic lipid homeostasis. Xiao X, Kennelly JP, Ferrari A, Clifford BL, Whang E, Gao Y, Qian K, Sandhu J, Jarrett KE, Brearley-Sholto MC, Nguyen A, Nagari RT, Lee MS, Zhang S, Weston TA, Young SG, Bensinger SJ, Villanueva CJ, de Aguiar Vallim TQ, Tontonoz P. Nat Metab. 2023 Jan;5(1):165-181.

Adipose-tissue plasticity in health and disease. Cell. Sakers A, De Siqueira MK, Seale P, Villanueva CJ.  2022 Feb 3;185(3):419-446.

When fat talks, the gut listens: IRONing out metabolism. De Siqueira MK, Villanueva CJ.  Cell Metab. 2021 Aug 3;33(8):1505-1506.

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis. Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ.  Elife. 2020 Aug 14;9:e52558.

Finding a Needle in a Haystack: Identification of a Beige Fat Progenitor. Villanueva CJ. Cell. 2020 Aug 6;182(3):537-539.

Phospholipid methylation regulates muscle metabolic rate through Ca2+transport efficiency. Verkerke ARP, Ferrara PJ, Lin CT, Johnson JM, Ryan TE, Maschek JA, Eshima H, Paran CW, Laing BT, Siripoksup P, Tippetts TS, Wentzler EJ, Huang H, Spangenburg EE, Brault JJ, Villanueva CJ, Summers SA, Holland WL, Cox JE, Vance DE, Neufer PD, Funai K.  Nat Metab. 2019 Sep;1(9):876-885.

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J.  Cell Metab. 2020 Feb 4;31(2):284-300.e7.

T cell-mediated regulation of the microbiota protects against obesity. Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O’Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL. Science. 2019 Jul 26;365(6451).

Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism. Pearson S, Loft A, Rajbhandari P, Simcox J, Lee S, Tontonoz P, Mandrup S, Villanueva CJ. Genes Dev. 2019 Jul 1;33(13-14):747-762.

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism.Geoghegan G, Simcox J, Seldin MM, Parnell TJ, Stubben C, Just S, Begaye L, Lusis AJ, Villanueva CJ.Mol Metab. 2019 Jun;24:44-63.

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O’Connell RM.PLoS Genet. 2019 Feb 15;15(2):e1007970.

Drosophila HNF4 Directs a Switch in Lipid Metabolism that Supports the Transition to Adulthood. Storelli G, Nam HJ, Simcox J, Villanueva CJ, Thummel CS. Dev Cell. 2019 Jan 28;48(2):200-214.

The E3 ligase MARCH5 is a PPARγ target gene that regulates mitochondria and metabolism in adipocytes. Bond ST, Moody SC, Liu Y, Civelek M, Villanueva CJ, Gregorevic P, Kingwell BA, Hevener AL, Lusis AJ, Henstridge DC, Calkin AC, Drew BG. Am J Physiol Endocrinol Metab. 2019 Feb 1;316(2):E293-E304.

Identification of phf16 and plpla3 as new adipogenic factors regulated by phytochemicals. Chang S, Yun UJ, Choi JH, Kim S, Lee AR, Lee DH, Seo M, Panic V, Villanueva CJ, Song N, Park Kw. Journal of cellular Biochemistry. 2018 Sept 11

Pi3ka-akt1-mediated prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice. song nj, chang sh, kim s, panic v, jang bh, yun uj, choi jh, li z, park km, yoon jh, kim s, yoo jh, ling j, thomas k, villanueva cj, li dy, ahn jy, ku jm, park kw. Cell death Dis. 2018 aug 29

A Hepatocyte FOXN3-α Cell Glucagon Axis Regulates Fasting Glucose. Karanth S, Adams JD, Serrano MLA, Quittner-Strom EB, Simcox J, Villanueva CJ, Ozcan L, Holland WL, Yost HJ, Vella A, Schlegel A. Cell Reports. 2018 Jul 10

Mitochondrial cardiomyopathies feature increased uptake and diminished efflux of mitochondrial calcium. Sommakia S, Houlihan PR, Deane SS, Simcox JA, Torres NS, Jeong MY, Winge DR, Villanueva CJ, Chaudhuri D. J Mol Cell Cardiol. 2017 SEPT 28

Global analysis of plasma lipids identifies liver-derived acylcarnitines as a fuel source for brown fat thermogenesis. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasqual M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ. Cell metabolism. 2017 SEPT 5

Inclusive Science Empowers the Superhero within Us All. Villanueva CJ. Cell Metabolism. 2017 SEPT 5

Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules. Song NJ, Chang SH, LI DY, Villanueva CJ, Park KW. Exp mol Med. 2017 Jul 7

RNA-Binding protein pspc1 promotes the differentiation-dependent nuclear export of adipocyte RNas. Wang J, Rajbhandari P, Damianov A, Han a, Sallam T, waki H, villanueva cj, Lee SD, Nielsen R, mandrup S, reue k, young SG, whitelegge J, saez e, Black dl, tontonoz p. Journal of clinical investigation. 2017 feb 13.

Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis. Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J. eLife. 2016 Sep 23.

ERa-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.  Drew BG, Hamidi H, Zhou z, Villanueva cj, krum SA, calkin ac, Parks Bw, ribas v, kalajian ny, phun j, daraei p, christofk hr, hewitt sc, korach ks, tontonoz p, lusis aj, slamon dj, hurvitz sa, hevener al.  Journal of biological chemistry. 2015 Feb 27;  290(9): 5566–558.

Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARgamma specifies lipid storage versus thermogenic gene programs. Villanueva CJ, Vergnes L, Wang J, Drew BG, Hong C, Tu Y, Hu Y, Peng X, Xu F, Saez E, Wroblewski K, Hevener AL, Reue K, Fong LG, Young SG, Tontonoz P. Cell Metabolism. 2013 Mar 5;17(3):423-35.

Dynamic and distinct histone modifications modulate the expression of key adipogenesis regulatory genes. Zhang Q, Ramlee MK, Brunmeir R, Villanueva CJ, Halperin D, Xu F. Cell Cycle. 2012 Dec 1;11(23):4310-22.

TLE3 is a dual-function transcriptional coregulator of adipogenesis. Villanueva CJ, Waki H, Godio C, Nielsen R, Chou WL, Vargas L, Wroblewski K, Schmedt C, Chao LC, Boyadjian R, Mandrup S, Hevener A, Saez E, Tontonoz P. Cell Metabolism. 2011 Apr 6;13(4):413-27.

Licensing PPARgamma to work in macrophages. Villanueva CJ, Tontonoz P. Immunity. 2010 Nov 24;33(5):647-9.

Specific role for acyl CoA:Diacylglycerol acyltransferase 1 (Dgat1) in hepatic steatosis due to exogenous fatty acids. Villanueva CJ, Monetti M, Shih M, Zhou P, Watkins SM, Bhanot S, Farese RV Jr. Hepatology. 2009 Aug;50(2):434-42

Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. Chao LC, Bensinger SJ, Villanueva CJ, Wroblewski K, Tontonoz P. Mol Endocrinol. 2008 Dec;22(12):2596-608.

Inhibitor of DNA binding 2 is a small molecule-inducible modulator of peroxisome proliferator-activated receptor-gamma expression and adipocyte differentiation. Park KW, Waki H, Villanueva CJ, Monticelli LA, Hong C, Kang S, MacDougald OA, Goldrath AW, Tontonoz P. Mol Endocrinol. 2008 Sep;22(9):2038-48.

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. Minehira K, Young SG, Villanueva CJ, Yetukuri L, Oresic M, Hellerstein MK, Farese RV Jr, Horton JD, Preitner F, Thorens B, Tappy L. J Lipid Res. 2008 Sep;49(9):2038-44.

Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin.
Streeper RS, Koliwad SK, Villanueva CJ, Farese RV Jr. Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E388-94.