Publications
2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1990s | 1980s |
2019
Romay, M.C., Toro, C., Iruela-Arispe, M.L. 2019. Emerging molecular mechanisms of vascular dementia. Curr Opin Hematol. 26(3):199-206. PMID: 30883434
Iruela-Arispe, ML. 2019. A focus on vascular malformations. Curr Opin Hematol. 26(3): 152-153. PMID: 30870249.
Keklikoglou, I., CIanciaruso, C., Guc, E., Squadrito, M.L., Spring, L.M., Tazzyman, S., Lambien, L., Poissonnier, A., Ferraro, G.B., Baer, C., Cassara, A., Guichard, A., Iruela-Arispe, M.L., Lewis, C.E., Coussens, L.M., Bardia, A., Jain, R.K., Pollard, J.W., De Palma, M. 2018. Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models. Nature Cell Biol. 21(2). PMID: 30598531 DOI: 10.1038/s41556-018-0256-3.
2018
Iruela-Arispe, M.L. 2018. Pumping blood with self-reliance and cooperation. JEM. 215(10):2480-2482. PMID: 30228158 PMCID: PMC6170172
Iruela-Arispe, M.L. 2018. A dual origin for blood vessels. Nature. 562(7726):195-197. PMID: 30291309
McDonald, A.I., Shirali, A.S., Aragón, R., Ma, F., Hernandez, G., Vaughn, D.A., Mack, J.J., Lim, T.Y., Sunshine, H., Zhao, P., Kalinichenko, V., Pelegrini, M., Ardehali, R., and Iruela-Arispe, M.L. 2018. Endothelial Regeneration of Large Vessels is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities. Cell Stem Stell. 23(2):210-225. PMID: 30075129 PMCID: PMC6178982 [Available on 2019-08-02]
Archer, B., Ueberrueck, T., Mack, J.J., Yousef, K., Jarenwattananon, N.N., Rall, D., Wypysek, D., Wiese, M., Bluemich, B., Wessling, M., Iruela-Arispe, M.L., Bouchard, L. 2018. Non-Invasive Quantification of Cell Density in 3D Gels by MRI. IEEE Trans Biomed Eng. 66(3):821-830. PMID: 30028689
Jelinek, D., Flores, A., Uebelhoer, M., Pasque, V., Plath, K., Iruela-Arispe, M.L., Christofk, H.R., Lowry, W.E., Coller, H.A. 2018. Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue. J Vis Exp. (136): e58860. PMID: 29985359 PMCID: PMC6101961 [Available on 2019-06-21] DOI: 10.3791/57760
Chattopadhyay, A., Yang, X., Mukherjee, P., Sulaiman, D., Fogelman, H.R., Grijalva, V., Dubinnet, S., Wasler, T.C., Paul, M.K., Salehi-Rad, R., Mack, J.J., Iruela-Arispe, M.L., Navab, M., Fogelman, A.M., Reddy, S.T. 2018. Treating the Intestine with Oral ApoA-I Mimetic Tg6F Reduces Tumor Burden in Mouse Models of Metastatic Lung Cancer. Sci Rep. 8(1): 9032. PMID: 29899427 PMCID: PMC5998131
Hilfenhaus, G., Nguyen, D., Freshman, J., Prajapati, D., Ma, F., Song, D., Ziyad, S., Cuadrado, M., Pellegrini, M., Bustelo, X.R., Iruela-Arispe, M.L. 2018. VAV3-induced Cytoskeletal Dynamics Contribute to Heterotypic Properties of Endothelial Barriers. J Cell Biol. 217(8):2813-2830. PMID: 29858212 PMCID: PMC6080943
Nowak-Sliwinska, P., Alitalo, K., Allen, A., Anisimov, A., Aplin, A.C., Auerbach, R., Augustin, A.G., Bates, D.O., van Beijnum, J.T., Bender, R.H.,F., Bergers,G., Bikfalvi, A., Bischoff, J., Böck, B.C., Brooks, P.C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A.M., Cleaver, O., Coukos, G., Davis, G.E., De Palma, M., Dimberg, A., Dings, R.P.M., Djonov, V., Dudley, A.C., Dufton, N.P., Fendt, S.M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesuière, B., Gong, Y., Griffin, R.J., Harris, A.L., Hughes, C.C.W., Hultgren, N.W., Iruela-Arispe, M.L., Irving, M., Jain, R.K., Kalluri, R., Kalucka, J., Kerbel, R.S., Kitajewski, J., Klaassen, I., Kleinmann, H.K., Koolwijk, P., Kuczynski, E., Kwak, B.R., K. Marien, J. M. Melero-Martin, L. L. Munn, R. F. Nicosia, A. Noel, J. Nurro, A.-K. Olsson, T. V. Petrova, Pietras, K., Pili, R., Pollard, J.W., Post, M.J., Quax, P.H.A., Rabinovich, G.A., Raica, M., Randi, A.M., Ribatti, D., Ruegg, C., Schlingemann, R.O., Schulte-Merker, S., Smith, L.E.H., Song, J.W., Stacker, S.A., Stalin, J., Stratman, A.N., Van de Velde, M., van Hinsbergh, V.W.M., Vermeulen, P.B., Waltenberger, J., Weinstein, B.M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M.C., Griffioen, A.W. 2018. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 21(3):425-532. PMID: 29766399 PMCID: PMC6237663 [Available on 2019-08-01]
Mack, J.J., Iruela-Arispe, M.L. 2018. NOTCH regulation of the endothelial cell phenotype. Curr Opin Hematol. PMID: 29547401
Freitas, V.M., Hilfenhaus, G., Iruela-Arispe, M.L. 2018. Metastasis of Circulating Tumor Cells: Speed Matters. Dev Cell. 45(1): 3-5.
Shirali, A.S., Romay, M.C., McDonald, A.I., Su, T., Steel, M.E., Iruela-Arispe, M.L. 2018. A multi-step transcriptional cascade underlies vascular regeneration in vivo. Scientific Reports. 8(1):5430.
Li, L. Zheng, Q. Bhutkar, A., Galván, J., Karamitopoulou, E., Necsulea, A., Noordermeer, D., Piersigilli, A., Peng, M., Perren, A., Ziobec, I., Robinson, H., Iruela-Arispe, M.L., Hanahan, D. 2018. GKAP acts as a genetic modulator of NMDAR signaling to govern invasive tumor growth. Cancer Cell. 33(4)736-751.e5.
Sereti, K.I., Nguyen, N.B., Kamran, P., Zhao, P., Ranjbarvaziri, S., Park, S., Sabri, S., Engel, J.L., Sung, K., Kulkarni, R.P., Ding, Y., Hsiai, T.K., Plath, K., Ernst, J., Sahoo, D., Mikkola, H.K.A., Iruela-Arispe, M.L., Ardehali, R. 2018. Analysis of cardiomyocyte clonal expansion during mouse heart development and injury. Nat Commun. 9(1): 754. PMCID: PMC5821855
Ziyad, S., Riordan, J.D., Cavanaugh, A.C., Su, T., Hernandez, G.E., Hilfenhaus, G., Morselli, M., Huyn, K., Wang, K., Chen, J.N., Dupuy, A.J., Iruela-Arispe, M.L. 2018. A forward genetic screen targeting the endothelium reveals a regulatory role for the lipid kinase Pi4Ka in myelo- and erythropoiesis. Cell Reports. 22(5): 1211-1224. PMCID: PMC5828030
Duran, I., Tenney, J., Warren, C.M., Sarukhanov, A., Csukasi, F., Skalansky, M., Iruela-Arispe, M.L., Krakow, D. 2018. NRP1 haploinsufficiency predisposes to the development of Tetralogy of Fallot. Am J Med Genet A. 176(3): 649-656.
Iruela-Arispe, L.M. 2018. VEGF. Chapter in: Encyclopedia of Signaling Molecules, 2nd Edition. Springer. Sangdun Choi, Editor-in-Chief. Pp 5915-5920.
Mundi, S., Massaro, M., Scoditti, E., Carluccio, M.A., van Hunsberg, V.W.M., Iruela-Arispe, M.L., De Caterina, R. 2018. Endothelial permeability, LDL deposition, and cardiovascular risk factors-a review. Cardiovasc. Res. 114(1): 35-52.
2017
Mack, J.J., Mosqueiro, T.S., Archer, B.J., Jones, W.M., Sunshine, H., Faas, G.C., Briot, A., Aragón, R., Su, Y.T., Romay, M.C., McDonald, A.I., Kuo, C., Lizama, C.O., Lane, T.F., Zovein, A.C., Fang, Y., Tarling, E.J., de Aguiar Vallim, T.Q., Navab, M., Fogelman, A.M., Bouchard, L.S., Iruela-Arispe., M.L. 2017. NOTCH1 is a mechanosensor in adult arteries. Nature Communications. 8(1), 1620.
Sunshine, H., Iruela-Arispe, M.L. 2017. Membrane lipids and cell signaling. Curr Opin Lipidol. 28(5): 408-413.
Toullec, A., Valerie, B., Rannou, E., Tarlet, G., Guipaud, O., Robine, S., Iruela-Arispe, L.M., Francois, A., Milliat, F. 2017. HIF-1α deletion in the endothelium, but not in the epithelium, protects from radiation-induced enteritis. Cell Mol Gastroenterol Hepatol. 5(1): 15-30.
Mukherjee, P., Hough, G., Chattopadhyay, A., Navab, M., Fogelman, H. R., Meriwether, D., Williams,K., Bensinger,S., Moller, T., Faull, K.F., Lusis, A., Iruela-Arispe, M.L., Bostrom, K., Tontonoz, P., Reddy, S., Fogelman, A. 2017. Transgenic Tomatoes Expressing the 6F Peptide and Ezetimibe Prevent Diet-induced Increases of Interferon-β and Cholesterol 25-hydroxylase in Jejunum. Journal of Lipid Research. J Lipid Res. 58(7):e076554.
Rose, B.A., Yokota, T., Chintalgattu, V., Ren, S., Iruela-Arispe, M.L., Khakoo, A.Y., Wang, Y. 2017. Cardiac Myocyte p38α Kinase Regulates Angiogenesis via Myocyte-Endothelial Cell Cross-talk During Stress-Induced Remodeling in Heart. Journal of Biological Chemistry. J Biol Chem. 292(31): 12787-12800.
Mintet, E., Lavigne, J., Paget, V., Tarlet, G., Buard, V., Guipaud, O., Sabourin, J.C., Iruela-Arispe, M.L., Milliat F, Francois A. 2017. Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice. Scientific Reports. 7(1)4933.
Jumabay, M., Zhumabai, J., Mansurov, N., Niklason, K.C., Guihard, P.J., Fogelman, A.M., Iruela-Arispe, M.L., Yao, Y., Saparov, A., Bostrom, K.I. 2017. Combined effects of bone morphogenetic protein 10 and crossveinless-2 on cardiomyocyte differentiation in mouse adipocyte-derived stem cells. J Cell Physiol. 233(3):1812-1822.
2016
Guihard, P.J., Yao, J., Blazquez-Medela, A.M., Iruela-Arispe, M.L., Bostrom, K.I., Yao, Y. 2016. Endothelial-Mesenchymal transition in vascular calcification of Ins2 Akita/+ Mice . PLoS One. 11(12):e0167936. PMCID: PMC5148029
Shirali, A.S., McDonald, A.I., Mack, J.J., Iruela-Arispe, M.L. 2016. Reproducible arterial denudation injury by infrarenal abdominal aortic clamping in a murine model. J Vis Exp. Nov 24;(117), e54755.
Inkeles, M.S., Teles, R.M., Pouldar, D., Andrade, P.R., Madigan, C.A., Lopez, D., Ambrose, M., Noursadeghi, M., Sarno, E.N., Rea, T.H., Ochoa, M.T., Iruela-Arispe, M.L., Swindell, W.R., Ottenhoff, T.H., Geluk, A., Bloom, B.R., Pellegrini, M., Modlin, R.L. 2016. Cell-type deconvolution with immune pathways identifies gene networks of host defense and immunopathology in leprosy. JCI Insight. 1(15):e88843. PMCID: PMC5033757
He, H., Mack, J.J., Güc, E., Warren, C.M., Squadrito, M.L., Kilarski, W.W., Baer, C., Freshman, R.D., McDonald, A.I., Ziyad, S., Swartz, M.A., De Palma, M., Iruela-Arispe, M.L. 2016. Perivascular macrophages limit permeability. ATVB. 36:2203-2212.
Briot, A., Bouloumie, A., Iruela-Arispe, M.L. 2016. Notch, lipids, and endothelial cells. Curr Opin Lipidol. 27(5):513-20.
Uebelhoer, M., Iruela-Arispe, M.L. 2016. Cross-talk between signaling and metabolism in the vasculature. Vascul Pharmacol. 83:4-9. PMCID: PMC4966612
Youssef, K., Jarenwattananon, N., Archer, B., Mack, J., Iruela-Arispe, L., Bouchard, L. 2016. 4-D flow control in porous scaffolds: Toward a Next Generation of Bioreactors. IEEE Trans Biomed Eng. 64(1):61-69.
2015
Briot, A., Civelek, M., Seki, A., Hoi, K., Mack, J.J., Lee, S.D., Kim, J., Hong, C., Yu, J., Fishbein, G.A., Vakili, L., Fogelman, A.M., Fishbein M.C., Lusis, A.J., Tontonoz, P., Navab, M., Berliner, J.A., Iruela-Arispe, M.L. 2015. Endothelial NOTCH1 is suppressed by circulating lipids and antagonizes inflammation during atherosclerosis. J Exp Med. 212(12):2147-63. PMCID: PMC4647265
Rannou, E., Francois, A., Toullec, A., Guipaud, O., Buard, V., Tarlet, G., Mintet, E., Jaillet, C., Iruela-Arispe, M.L., Benderitter, M., Sabourin, J.C., Milliat, F. 2015. In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury. Sci Rep. 5:15738. PMCID: PMC4625166
Hernandez-Garcia R, Iruela-Arispe ML, Reyes-Cruz G, Vazquez-Prado J. 2015. Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascul Pharmacol. 74:60-72.
Moughon D, He H, Schokrpur S, Jiang ZK, David J, Lin C, Iruela-Arispe ML, Dorigo O, Wu L. 2015. Macrophage blockade using CSF1R inhibitors reverses the vascular leakage underlying malignant ascites in late-stage epithelial ovarian cancer. Cancer Res. 75:(22):4742-52. PMCID: PMC4675660
McDonald AI, Iruela-Arispe ML. 2015. Healing arterial ulcers: Endothelial lining regeneration upon vascular denudation injury. Vascul Pharmacol. 72:9-15. PMCID: PMC4547868
Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML. 2015. Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. J Cell Sci. 128(12):2236-48. PMCID: PMC4487014
Simons M, Alitalo K, Annex BH, Augustin HG, Beam C, Berk BC, Byzova T, Carmeliet P, Chilian W, Cooke JP, Davis GE, Eichmann A, Iruela-Arispe ML, Keshet E, Sinusas AJ, Ruhrberg C, Woo YJ, Dimmeler S; American Heart Assoc. Council on Basic Cardiovascular Sciences and Council on Cardiovascular Surgery and Anesthesia. 2015. State-of-the-Art methods for evaluation of Angiogenesis and Tissue Vascularization: A scientific statement from the American Heart Association. Circ Res. 116(11):e99-132.
Rodriguez-Manzaneque, J.C., Fernandez- Rodriguez, R., Rodriguez-Baena, F.J., Iruela-Arispe, M.L.. 2015. ADAMTS proteases in vascular biology. Matrix Biol 44-46:38-45.
Briot, A., Iruela-Arispe, M.L.. 2015. Blockade of specific NOTCH ligands: a new promising approach in cancer therapy. Cancer Discov 5: 112-114. PMCID: PMC4342039
Domigan, C.K., Ziyad, S., Iruela-Arispe, M.L.. 2015. Canonical and noncanonical vascular endothelial growth factor pathways: new developments in biology and signal transduction. Arterioscler Thromb Vasc Biol 35: 30-39. PMCID: PMC4270848
2014
Briot, A., Jaroszewicz, A., Warren, C.M., Lu, J., Touma, M., Rudat, C., Hofmann, J.J., Airik, R., Weinmaster, G., Lyons, K., Wang, Y., Kispert, A., Pellegrini, M., Iruela-Arispe, M.L.. 2014. Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. Dev Cell 31: 707-721. PMCID: PMC4311887
Domigan, C.K., Iruela-Arispe, M.L.. 2014. Stealing VEGF from thy neighbor. Cell 159: 473-474.
Warren, C.M., Iruela-Arispe, M.L.. 2014. Podosome rosettes precede vascular sprouts in tumour angiogenesis. Nat Cell Biol 16: 928-930.
Nowak-Sliwinska, P., Segura, T., Iruela-Arispe, M.L.. 2014. The chicken chorioallantoic membrane model in biology, medicine and bioengineering. Angiogenesis 17: 779-804.
Michael, I.P., Westenskow, P.D., Hacibekiroglu, S., Greenwald, A.C., Ballios, B.G., Kurihara, T., Li, Z., Warren, C.M., Zhang, P., Aguilar, E., Donaldson, L., Marchetti, V., Baba, T., Hussein, S.M., Sung, H.K., Iruela-Arispe, M.L., Rini, J.M., van der Kooy, D., Friedlander, M., Nagy, A.. 2014. Local acting Sticky-trap inhibits vascular endothelial growth factor dependent pathological angiogenesis in the eye. EMBO Mol Med 6: 604-623.
Goddard, L.M., Murphy, T.J., Org, T., Enciso, J.M., Hashimoto-Partyka, M.K., Warren, C.M., Domigan, C.K., McDonald, A.I., He, H., Sanchez, L.A., Allen, N.C., Orsenigo, F., Chao, L.C., Dejana, E., Tontonoz, P., Mikkola, H.K., Iruela-Arispe, M.L.. 2014. Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell 156: 549-562.
Griffin, D.R., Borrajo, J., Soon, A., Acosta-Velez, G.F., Oshita, V., Darling, N., Mack, J., Barker, T., Iruela-Arispe, M.L., Segura, T.. 2014. Hybrid photopatterned enzymatic reaction (HyPER) for in situ cell manipulation. Chemobiochem 15: 233-242.
Warren, C.M., Ziyad, S., Briot, A., Der, A., Iruela-Arispe, M.L.. 2014. A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes. Science Signaling 7: 233-242.
2013
Milde, F., Lauw, S. Koumoutsakos, P., and Iruela-Arispe, M.L.. 2013. The mouse retina in 3D: quantification of vascular growth and remodeling. Integrative Biology : 233-242.
Turlo, K.A., Scapa, J., Bagher, P., Jones, A.W., Feil, R., Korthuis, R.J., Segal, S.S., Iruela-Arispe, M.L.. 2013. Beta1-Integrin is essential for vasoregulation and smooth muscle survival In Vivo. Arterioscler Thromb Vasc Biol 33: 2325-2335.
Iruela-Arispe, M.L., Beitel, G.J.. 2013. Tubulogenesis. Development 140: 2851-2855.
Corada, M., Orsenigo, F., Morini, M.F., Pitulescu, M.E., Bhat, G., Nyqvist, D., Breviario F., Conti, V., Briot, A., Iruela-Arispe, M.L., Adams, R.H., Dejana, E. 2013. Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat. Commun. 4:2609. PMCID: PMC3826640
Goddard, L.M., Ton, A.M., Org, T., Mikkola, H.K., Iruela-Arispe, M.L.. 2013. Selective suppression of endothelial cytokine production by progesterone receptor. Vascul. Pharmacol 59: 36-43 . PMCID: PMC3819224
Janzen, D.M., Rosales, M.A., Paik, D.Y., Lee, D.S., Smith, D.A., Witte, O.N., Iruela-Arispe, M.L., Memarzadeh, S.. 2013. Progesterone receptor signaling in the microenvironment of endometrial cancer influences its response to hormonal therapy. Cancer Res 73: 4697-4710. PMCID: PMC3752407
Roodhart, J.M.L., He, H., Daenen, L.G.M., Monvoisin, A., Barber, C., van Amersfoort, M., Hofmann, J.J., Radtke, F., Lane, T.F., Voest, E.E., Iruela-Arispe, M.L.. 2013. Notch1 regulates angio-supportive bone-marrow-derived cells in mice: relevance to chemoresistance. Blood 122: 143-153. PMCID: PMC3701902
Baer, C., Squadrito, M.L., Iruela-Arispe, M.L., De Palma, M.. 2013. Reciprocal interactions between endothelial cells and macrophages in angiogenic vascular niches. Exp Cell Res 319: 1626-1634.
Cristofaro, B., Shi, Y., Faria, M., Suchting, S., Leroyer, A.S., Trindade, A., Duarte, A., Zovein, A.C., Iruela-Arispe, M.L., Nih, L.R., Kubis, N., Henrion, D., Loufrani, L., Todiras, M., Schleifenbaum, J., Gollasch, M., Zhuang, Z.W., Simons, M., Eichmann, A., le Noble, F.. 2013. Dll4-Notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models. Development 140: 1720-1729. PMCID: PMC4074271
Goddard, L.M., Iruela-Arispe, M.L.. 2013. Cellular and molecular regulation of vascular permeability. Thromb. Haemost 109: 407-415. PMCID: PMC3786592
Defalco, T., Saraswathula, A., Briot, A., Iruela-Arispe, M.L., Capel, B.. 2013. Testosterone levels influence mouse fetal leydig cell progenitors through Notch signaling. Biol. Reprod 88: 1-12. PMCID: PMC4013875
Mack, J.J., Youssef, K., Noel, O.D., Lake, M.P., Wu, A., Iruela-Arispe, M.L., Bouchard, L.S.. 2013. Real-time maps of fluid flow fields in porous biomaterials. Biomaterials 34: 1980-86. PMCID: PMC3714210
2012
Domigan, C.K., Iruela-Arispe, M.L.. 2012. Recent advances in vascular development. Curr Opin Hematol 19: 176-183. PMCID: PMC3666551
Howell, M.D., Torres-Collado, A.X., Iruela-Arispe, M.L., Gottschall, P.E.. 2012. Selective decline of synaptic protein levels in the frontal cortex of female mice deficient in the extracellular metalloproteinase ADAMTS1. PLoS One 7: e47226. PMCID: PMC3469530
Hofmann, J.J., Briot, A., Enciso, J., Zovein, A.C., Ren, S., Zhang, Z.W., Radtke, F., Simons, M., Wang, Y., Iruela-Arispe, M.L.. 2012. Endothelial deletion of murine Jagged1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development 139: 4449-4460. PMCID: PMC3509736
He, H., Xu, J., Warren, C.M., Duan, D., Wu, L., Iruela-Arispe, M.L.. 2012. Endothelial cells provide an instructive niche for the differentiation and functional polarization of M2-like macrophages. Blood 120: 3152-3162. PMCID: PMC3471522
Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., Yaniv, K.. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor-1. Nat. Med 18: 967-973. PMCID: PMC3959651
Chhabra, A., Lechner, A.J., Ueno, M., Acharya, A., van Handel, B., Wang, Y., Iruela-Arispe, M.L., Tallquist, M.D., Mikkola, H.K.. 2012. Trophoblasts regulate the placental hematopoietic niche through PDGF-B signaling. Dev. Cell 13: 651-659. PMCID: PMC3395466
Hall-Glenn, F., De Young, R.A., Huang, B.L., van Handel, B., Hofmann, J.J., Chen, T.T., Choi, A., Ong, J.R., Benya, P.D., Mikkola, H., Iruela-Arispe, M.L., Lyons, K.M.. 2012. CCN2/Connective tissue growth factor is essential for pericyte adhesion and endothelial basement membrane formation during angiogenesis. PLoS One 7: e30562. PMCID: PMC3282727
Turlo, K.A., Noel, O.D., Vora, R., LaRussa, M., Hall-Glenn, F., Iruela-Arispe, M.L.. 2012. An essential requirement for Beta-1 integrin in the assembly of extracellular matrix proteins within the vascular wall. Dev. Biol 365: 23-35. PMCID: PMC3590017
Cooley,M.A., Fresco, V.M., Dorlon, M.E., Twal, W.O., Lee, N.V., Barth, J.L., Kern, C.B., Iruela-Arispe, M.L., Argraves, W.S.. 2012. Fibulin-1 is required during cardiac ventricular morphogenesis for versican cleavage, suppression of ErbB2 and Erk1/2 activation, and to attenuate trabecular cardiomyocyte proliferation. Dev. Dyn 241: 303-314. PMCID: PMC3489172
Scheppke, L., Murphy, E., Zarpellon, A., Hofmann, J.J., Merkulova, A., Shields, D., Weis, S., Byzova, T., Ruggeri, Z., Iruela-Arispe, M.L., Cheresh, D. 2012. Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood 119: 2149-2158. PMCID: PMC3311249
Youssef, K., Mack, J.J., Iruela-Arispe, M.L., Bouchard, L.S.. 2012. Macro-scale topology optimization for controlling internal shear stress in a porous scaffold bioreactor. Biotechnol. Bioeng 109: 1844-1854.
2011
Ziyad, S., Iruela-Arispe, M.L.. 2011. Molecular mechanisms of tumor angiogenesis. Genes and Cancer. 2(12): 1085-96. PMCID: PMC3411131
Iruela-Arispe, M.L. 2011. LUMENating blood vessels. Dev. Cell 20: 412-414. PMCID: PMC3099250
Anderson, S.M., Shergill, B., Barry, Z.T., Manousiouthakis, E., Chen, T.T., Botvinick, E., Platt, M.O., Iruela-Arispe, M.L., and Segura, T. 2011. VEGF internalization is not required for VEGFR-2 phosphorylation in bioengineered surfaces with covalently linked VEGF. Integrative Biology 3: 887-896. PMCID: PMC3621282
2010
Corada, M., Nyqvist, D., Orsenigo, F., Caprini, A., Giampietro, C., Taketo, M.M., Iruela-Arispe, M.L., Adams, R.H., Dejana, E.. 2010. The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating DII4/Notch signaling. Dev. Cell 18: 938-949.
Hofmann, J.J., Zovein, A.C., Koh, H., Radtke, F., Weinmaster, G., and Iruela-Arispe, M.L.. 2010. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development 137: 4061-4072. PMCID: PMC2976287
Turlo, K.A., Gallaher, S.D., Vora, R., Laski, F.A., Iruela-Arispe, M.L.. 2010. When Cre-mediated recombination in mice does not result in protein loss. Genetics (highlighted by Journal) 186: 959-967. PMCID: PMC2975293
Zovein, A.C., Turlo, K.A., Ponec, R.M., Lynch, M.R., Chen, K.C., Hofmann, J.J., Cox, T.C., Gasson, J.C., Iruela-Arispe, M.L.. 2010. Vascular remodeling of the vitelline artery initiates extra-vascular emergence of hematopoietic clusters. Blood (Cover) 116: 3435-3444.
Da Silva, R.G., Tavora, B., Robinson, S.D., Reynolds, L.E., Szekeres, C., Lamar, J., Batista, S., Kotourou, V., Germain, M.A., Reynolds, A.R., Jones, D.T., Watson, A.R., Jones, J.L., Harris, A., Hart, I.R., Iruela-Arispe, M.L., Dipersion, C.M., Kreidberg, J.A., Hodivala-Dilke, K.M.. 2010. Endothelial alpha 3 beta1 integrin represses pathological angiogenesis and sustains endothelial VEGF. Am. J. Pathol 177: 1534-1548. PMCID: PMC2928983
Warren, C.M., and Iruela-Arispe, M.L.. 2010. Signaling circuitry in vascular morphogenesis. Curr Opin Hematol 17: 213-218. PMCID: PMC2921923
Arroyo, A.G., and Iruela-Arispe, M.L.. 2010. Extracellular matrix, inflammation, and the angiogenic response. Cardiovasc Res 86: 226-235. PMCID: PMC2856193
Chen, T.T., Luque, A., Lee, S., Anderson, S.M., Segura, T., Iruela-Arispe, M.L.. 2010. Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. J Cell Biol 188: 595-609. PMCID: PMC2828913
Zovein, A.C., Luque, A., Turlo, K.A., Hofmann, J.J., Yee, K.M., Becker, M.S., Fassler, R., Mellman, I., Lane, T.F., Iruela-Arispe, M.L.. 2010. Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanism. Dev. Cell 18: 39-51. PMCID: PMC3178410
Stockman, C., Kerdiles, Y., Nomaksteinsky, M., Weidemann, A., Takeda, N., Doedens, A., Torres-Collado, A.X., Iruela-Arispe, M.L., Nizet, V., Johnson, R.S.. 2010. Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis. Proc Natl Acad Sci USA 107: 4329-4334. PMCID: PMC2840078
Lee, Y.J., Koch, M., Karl, D., Torres-Collado, A.X., Fernando, N.T., Rothrock, C., Kuruppu, D., Ryeom, S., Iruela-Arispe, M.L., Yoon, S.S.. 2010. Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1. Cancer Res 70: 948-956. PMCID: PMC2934910
Priceman, S.J., Sung, J.L., Shaposhnik,, Z., Burton, J.B., Torres-Collado, A.X., Moughon, D.L., Johnson, M., Lusis, A.J., Cohen, D.A., Iruela-Arispe, M.L., and Wu, L.. 2010. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic of anti-angiogenic therapy. Blood 115: 1461-471. PMCID: PMC2826767
Iruela-Arispe, M.L., and Lee, S.. 2010. Mechanisms underlying context-dependent VEGF signaling for distinct biological responses. Handbook of Cell Signaling, Second Ed.: 1919-1925.
2009
Zovein, A.C., and Iruela-Arispe, M.L.. 2009. Time to cut the cord: placental HSCs grow up. Cell Stem Cell 5: 351-352.
Skuli, N., Liu, L., Runge, A., Wang, T., Yuan, L., Patel, S., Iruela-Arispe, M.L., Simon, M.C., Keith, B.. 2009. Endothelial deletion of hypoxia-inducible factor-2alpha(HIF-2alpha) alters vascular function and tumor angiogenesis. Blood 114: 469-477. PMCID: PMC2714217
Anderson, S.M., Chen, T.T., Iruela-Arispe, M.L., Segura, T.. 2009. The phosphorylation of vascular endothelial growth factor receptor-2 (VEGFR-2) by engineered surfaces with electrostatically or covalently immobilized VEGF. Biomaterials 30: 4618-4628. PMCID: PMC2826152
Speck, N.A., Iruela-Arispe, M.L.. 2009. Conditional Cre/LoxP Strategies for the Study of Hematopoietic Stem Cell Formation. Blood Cells Mol. Dis 43: 6-11. PMCID: PMC2723839
Rodriguez-Manzaneque, J.C., Carpizo, D., Plaza-Calonge, M.D., Torres-Collado, A.X., Thai, S.N., Simons, M., Horowitz, A., and Iruela-Arispe, M.L.. 2008. Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. Int. J. Biochem. Cell Biol. 41:800-810. PMCID: PMC3807939
Iruela-Arispe, M.L., Davis, G.E. 2009. Cellular and molecular mechanisms of vascular lumen formation. Dev Cell. 16:222-31.
Iruela-Arispe, M.Luisa. 2008. Regulation of Thrombospondin1 by Extracellular Proteases. Current Drug Targets 9: 863-868. PMCID: PMC3010394
Zovein, A.C. Hofmann, J.J., Lynch, M., French, W.J., Turlo, K.A., Yang, Y., Becher, M.S., Zanetta, L., Dejana, E., Gasson, J. Tallquist, M.D., and Iruela-Arispe, M.L.. 2008. Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell 3: 625-636. PMCID: PMC2631552
Suarez, Y., Fernandez-Hernando, C., Yu, J., Gerber, S.A., Harrison, K.D., Pober, J.S. Iruela-Arispe, M.L., Merkernschlager, M., and Sessa, W.C.. 2008. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. PNAS 105: 14082-14087. PMCID: PMC2544582
Guo, W., Lasky, J.L., Chang, C.J., Mosessian, S., Lewis, X., Xiao, Y., Yeh, J.E., Chen, J. Y., Iruela-Arispe, M.L., Varella-Garcia, M., and Wu, H.. 2008. Multi-genetic events collaboratively contribute to Pten-deficient leukemia stem-cell formation. Nature 453:529-533. PMCID:PMC2840044
Stankunas, K. Hang, C.T., Tsun, Z.Y. Chen, H., Lee, N.V., Wu, J.I., Shang, C., Bayle, J.H., Shou, W., Iruela-Arispe, M.L., and Chang, C.P.. 2008. Endocardial Brg1 represses ADAMTS1 to maintain the microenvironment for myocardial morphogenesis. Dev. Cell 14: 298-311. PMCID: PMC2274005
Misra, S., Lee, N. Fu, A.A., Raghavakaimal, S., Mandrekar, J., Bjarnason, H., McKusick, M.A., Iruela-Arispe, L., Mukhopadhyay, D.. 2008. Increased expression of a disintegrin and metalloproteinase thrombospondin 1 in thrombosed hemodialysis grafts. J. Vasc. Interv. Radiol 19: 111-119.
Iruela-Arispe, M.L.. 2008.Endothelial Cell Activation. Chapter in: Angiogenesis: An Integrative Approach from Science to Medicine. Springer, Editors: Judah Folkman and J. Figg, 35-43.
2007
Lundkvist, A., Lee, S., Iruela-Arispe, L., Betsholtz, C., Gerhardt, H.. 2007. Growth factor gradients in vascular patterning. Novartis Found. Symp 283: 194-201.
Lee, S. and Iruela-Arispe, M.L.. 2007. The Extracellular Matrix and VEGF Processing Anti-Angiogenesis, 2nd edition : 194-201.
Hofmann, J.J. and Iruela-Arispe M.L.. 2007. Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expr Patterns 7: 461-470. HofmannGeneExprPat_2007
Lee, M., Chen, T.T., Iruela-Arispe, M.L., Wu, B.M., Dunn, J.C.. 2007. Modulation of protein delivery from modular polymer scaffolds. Biomaterials 28: 1862-1870. LeeM_Biomaterials_2007
Hellstrom, M., Phng, L.K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.K., Karlsson, L., Gaiano, N., Yoon, K., Rossant, J., Iruela-Arispe, M.L., Kalen, M., Gerhardt, H., Betsholtz, C.. 2007. D114/Notch1 regulates formation of tip cells during angiogenesis. Nature 445: 776-780. Hellstrom_Nature_2007
Hofmann, J.J., Iruela-Arispe, M.L.. 2007. Notch signaling in blood vessels: who is talking to whom about what? Circulation Res 100: 1556-1568. Hofmann_2007
Lee, S., Chen, T.T., Barber, C.L., Jordan, M.C., Murdock, J., Desai, S., Ferrara, N., Nagy, A., Roos, K.P. and Iruela-Arispe, M.L.. 2007. Autocrine VEGF Signaling Is Required for Vascular Homeostasis. Cell 130: 691-703. PMCID: PMC3010851
2006
Lee, N.V. and Iruela-Arispe, M.L.. 2006. Thrombospondins and Angiogenesis Tumor Angiogenesis: Mechanisms and Cancer Therapy : 233-245.
Zovein, A.C. and Iruela-Arispe, M.L.. 2006. My O’Myeloid, a tale of two lineages. PNAS 103: 12959-12960. PMCID: PMC1559733
Iruela-Arispe, M.L.. 2006. When it comes to lymphatics, it is all a question of time. Am J. Pathol 169: 347-350. PMCID: PMC1698778
Barber, C.L., and Iruela-Arispe, M.L.. 2006. The ever-Elusive Endothelial Progenitor Cell: Identities, Functions and Clinical Implications. Pediatr Res 59: 26-32.
Alva, J.A., Zovein, A.C., Monvoisin, A., Murphy, T., Salazar, A., Harvey, N.L., Carmeliet, P. and Iruela-Arispe, M.L.. 2006. VE-Cadherin-Cre-recombinase transgenic mouse: A tool for lineage analysis and gene deletion in endothelial cells. Dev Dyn 235: 759-767.
Yang, L.V., Radu, C.G., Roy, M., Lee, S., McLaughlin, J., Teitell, M.A., Iruela-Arispe M.L. and Witte, O.N.. 2006. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Mol Cell Biol 27: 1334-1347. PMCID: PMC1800706
Kern, C.B., Twal, W.O., Mjaatvedt, C.H., Fairey, S.E., Toole, B.P., Iruela-Arispe, M.L., Argraves, W.S. 2006. Proteolytic cleavage of versican during cardiac cushion morphogenesis. Dev Dyn 235: 2238-2247. PMCID: PMC1828280
Torres-Collado, A.X., Kisiel, W., Iruela-Arispe, M.L., Rodriguez-Manzaneque, J.C. 2006. ADAMTS1 interacts with, cleaves and modifies the extracellular location of the matrix inhibitor tissue factor pathway inhibitor-2 (TFPI-2). J Biol Chem 281: 17827-17837.
Monvoisin, A., Alva, J.A., Hofmann, J.J., Zovein, A.C., Lane, T.F., and Iruela-Arispe, M.L. 2006. VE-cadherin-CreER(T2) transgenic mice: A model for inducible recombination in the endothelium. Dev. Dyn 235: 3413-3422.
Lee, N.V., Sato, M., Annis, D.S., Loo, J.A., Wu, L., Mosher, D.F. and Iruela-Arispe, M.L. 2006. ADAMTS1 mediates the release of anti-angiogenic polypeptides from TSP1 and TSP2. The EMBO J 25: 5270-5283. PMCID: PMC1636613
Hashimoto-Partyka, M., Lydon, J., and Iruela-Arispe, M.L. 2006. Generation of a mouse for conditional excision of progesterone receptor (PRCE). Genesis 44: 391-395. genesis_(44).391.2006
Lee, N.V., Rodriguez-Manzaneque, J.C., Thai, S.N., Twal, W.O., Luque, A., Lyons, K.M., Argraves, W.S., Iruela-Arispe, M.L. 2005. Fibulin-1 acts as a cofactor for the matrix metalloprotease ADAMTS-1. J Biol Chem 280: 34796-34804.
Cho, H.M., Rosenblatt, J.D., Kang, Y.S., Iruela-Arispe, M.L., Morrison, S.L., Penichet, M.L., Kwon, Y.G., Kim, T.W., Webster, K.A., Nechustan, H. and Shin, S.U. 2005. Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein. Mol Cancer Ther 4: 956-967.
2005
Iruela-Arispe, M.L. 2005. Vascular Development and Angiogenesis Book Title: Encyclopedia of Molecular Cell Biology and Molecular Medicine : 201-232. vasdev_angio_2005
Lee, S., Jilani, S.M. Nikolova, G.V., Carpizo, D., and Iruela-Arispe, M.L. 2005. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors. J Cell Biol 169:681-691. PMCID: PMC2171712
Krampert, M., Kuenzle, S., Thai, S.N., Lee, N., Iruela-Arispe, M.L., Werner, S. 2005. ADAMTS1 proteinase is upregulated in wounded skin and regulates migration of fibroblasts and endothelial cells. J Biol Chem 280: 23844-23852. Krampert_jbc_280(2005)
2004
Thomas-Tikkonenko, A. and Iruela-Arispe, M.L.. 2004. Whence Thrombospondin? Cancer Biology and Therapy 3: 406-7. ThomasTikhonenko(2004)
Alva, J.A. and Iruela-Arispe, M.L.. 2004. Notch Signaling in Vascular Morphogenesis. Current Opinion in Hematology 11: 278-283. Alva_Curr.Op.Hem(2004)
Iruela-Arispe, M.L., Luque, A. and Lee, N.. 2004. Thrombospondin modules in Angiogenesis. Int. Journal of Biochemistry and Cell Biol 36: 1070-1078. IJBCB_36.70(2004)
Iruela-Arispe, M.L.. 2004. Angiogenesis: novel and basic science insights and human therapy. Keystone Symposium – IDrugs 7: 111-113. IDrugs_KeystoneSymp(2004)
Fiala, M., Murphy, T., MacDougall, J., Yang, W., Luque, A., Iruela-Arispe, L., Cashman, J., Buga, G., Byrns, R.E., Barbaro, G., Arthos, J.. 2004. HAART drugs induce mitochondrial damage and intercellular gaps and gp120 causes apoptosis. Cardiovasc Toxicol 4: 327-337. Fiala_HumanaPress(2004)
Calzada, M.J., Zhou, L., Sipes, J.M., Zhang, J., Krutzsch, H.C., Iruela-Arispe M.L., Annis, D.S., Mosher, D.F., Roberts, D.D.. 2004. Alpha4 Beta1 Integrin Mediates Selective Endothelial Cell Responses to Thrombospondins 1 and 2 In Vitro and Modulates Angiogenesis In Vivo. Circ Res 94: 462-470.
2003
Ellwood-Yen K, Graeber TG, Wongvipat J, Iruela-Arispe ML, Zhang J, Matusik R, Thomas GV, Sawyers CL. 2003. Myc-driven murine prostate cancer shares molecular features with human prostate tumors. Cancer Cell 4: 223-238. ElwoodYen
Iruela-Arispe, M.L., Carpizo, D., Luque, A.. 2003. ADAMTS1: a matrix metalloprotease with angioinhibitory properties. Ann N Y Acad Sci 995: 183-190.
Jilani SM, Murphy TJ, Thai SN, Eichmann A, Alva JA, Iruela-Arispe ML. 2003. Selective binding of lectins to embryonic chicken vasculature. J Histochem Cytochem 51: 597-604.
Luque, A., Carpizo, D.R., Iruela-Arispe, M.L. 2003. ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem. 278:23656-665. Luque_Jbc_278(2003)
2002
Park H.J., Kong D., Iruela-Arispe M.L., Begley U, Tang D, Galper J.B.. 2002. 3-hydroxy-3methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circ Res 91: 143-150.
Gaspar, J., Thai, S., Voland, C., Dube, A., Libermann, T.A., Iruela-Arispe, M.L. and Oettgen, P.. 2002. Opposing functions of the Ets factors NERF and ELF-1 in the regulation of the Tie genes during chicken blood vessel development. Art. Throm. and Vasc. Biol 22: 1106-1112.
Adams, J.Y., Johnson, M., Sato, M., Berger, F., Gambhir, S.S., Carey, M., Iruela-Arispe, M.L. and Lily, Wu. 2002. Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nature Med 8: 891-897.
Thai, S.N.M. and Iruela-Arispe, M.L.. 2002. Expression of ADAMTS1 during murine developmeac.els-cdn.com/…/1-s2.0-S0925477302001156-main.pdfnt. Mechanisms of Development 115: 181-185.
Rogriguez-Manzaneque, J.C., Westling, J., Thai, S.N., Luque, A., Knauper, V., Murphy, G., Sandy, J.D., and Iruela-Arispe, M.L.. 2002. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. Biochem. and Biophys. Res. Comm 293: 501-508.
Murayama, Y., Vinuela, F., Tateshima, S., Gonzalez, N.R., Song, J.K., Mahdavieh, H., Iruela-Arispe, M.L.. 2002. Cellular responses of bioabsorbable polymeric material and Guglielmi detachable coil in experimental aneurysms. Stroke 33: 1120-1128.
2001
Rodriguez-Manzaneque, J.C., Lane, T.F., Ortega, M.A., Hynes, R.O., Lawler, J., and Iruela-Arispe, M.L.. 2001. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. PNAS 98: 12485-12490. PMCID: PMC60080
Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M.L. and Weinmaster, G.. 2001. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mechanisms of Development 108: 161-164.
Augustin, H.G., Iruela-Arispe, M.L., Rogers, P., and Smith, S.. 2001. Vascular Morphogenesis in the Female Reproductive System. Springer-Birkhaeuser, New York : 161-164.
Saaristo, A., Karkkainen, M.J., Alitalo, K., Montesano, R., Iruela-Arispe, M.L., Pepper, M.S.. 2001. Growth factor regulation of physiological angiogenesis in the mammary gland Chapter in: Vascular Morphogenesis in the Female Reproductive System : 25-40. Saaristo_et_al_2001
Iruela-Arispe, M.L., Ortega, M.A., Oikemus, S. and Pepper, M.S.. 2001. Vascular morphogenesis in the mammary gland – introduction and overview Vascular Morphogenesis in the Female Reproductive System : 3-24. Arispe_et_al_2001
Sandy, J.D., Westling, J., Kenagy, R.D., Iruela-Arispe, M.L., Verscharen, C., Rodriguez-Manzaneque, J.C., Zimmerman, D., Lemire, J.M., Fischer, J.W., Wight, T.N and Clowes, A.W.. 2001. Versican V1 proteolysis in human aorta in vivo occurs at the Glu441-Ala442 bond, a site which is cleaved by recombinant ADAMTS-1 and ADAMTS-4. J. Biol. Chem 276: 13372-13378.
Dube, A., Thai, S., Gaspar, J., Rudders, S., Libermann, T.A., Iruela-Arispe, M.L., and Oettgen, P.. 2001. ELF-1 is a transcriptional regulator of the Tie-2 gene during vascular development. Circ. Res 88: 237-244.
Graubert, M.D., Ortega, M.A., Kessel, B., Mortola, J.F. and Iruela-Arispe, M.L.. 2001. Vascular repair after menstruation involves regulation of vascular endothelial growth factor-receptor phosphorylation by sFLT-1. Am. J. Pathol 158: 1399-1410. PMCID: PMC1891924
2000
Carpizo, D. and Iruela-Arispe, M.L.. 2000. Endogenous regulators of angiogenesis – Emphasis on proteins with thrombospondin – type I motifs. Cancer and Metastasis Reviews 19: 159-165. Carpizo_CanMet_19(2000)
Pal, S., Iruela-Arispe, M.L., Harvey, V.S., Zeng, H., Nagy, J.A., Dvorak, H.F. and Mukhopadhyay, D.. 2000. Retinoic acid selectively inhibits the vascular permeabilizing effect of VPF/VEGF, an early step in the angiogenic cascade. Microvasc. Res 60: 112-120.
Rodriguez-Manzaneque, J.C., Milchanowski, A.B., Dufour, E.K., Leduc, R., and Iruela-Arispe, M.L.. 2000. Characterization of Meth-1/Adamts-1 processing reveals two distinct active forms. J. Biol. Chem 275: 33471-33479.
Streit, M., Valesco, P., Riccardi, L., Spencer, L., Brown, L.F., Janes, L., Lange-Asschenfeldt, B. ,Yano, K., Hawighorst, T., Iruela-Arispe, M.L., Detmar, M.. 2000. Thrombospondin-1 suppresses wound healing and granulation tissue formation in the skin of transgenic mice. The EMBO Journal 19: 3272-3282 .
Pepper, M.S., Baetens, D., Mandroita, S.J., Di Sanza, C., Oikemus, S., Lane, T.F., Soriano, J.V., Orci, L., Montesano, R., Iruela-Arispe, M.L.. 2000. Regulation of VEGF and VEGF receptor expression in rodent mammary gland during pregnancy, lactation and involution. Dev. Dynamics 218: 507-524.
Lee S.W., Reimer, C.L., Fang, L., Iruela-Arispe, M.L. and Aaronson, S.A.. 2000. Overexpression of kinase-associated phosphatase (KAP) in Breast and Prostate Cancer Inhibition of the transformed phenotype by antisense KAP Expression. Molec. & Cell. Biol 20: 1723-1732. PMCID: PMC85355
Chandrasekaran, L., He, Z.C., Al-Barazi, H., Krutzch, H.C., Iruela-Arispe, M.L., and Roberts, D.D.. 2000. Cell contact-dependent activation of a 3b1 integrin modulates endothelial cell responses to thrombospondin-1. Mol. Biol. Cell 11: 2885-2900. PMCID: PMC14963
Rodriguez-Manzaneque, J.C., Graubert, M., and Iruela-Arispe, M.L.. 2000. Endothelial cell dysfunction following prolonged activation of progesterone receptor. Human Reproduction 15: 39-47. Juan_hum_rep_15(2000)
1990s
Iruela-Arispe, M.L., Ortega, M.A., and Vazquez, F.. 1999. Antiangiogenic Function of Thrombospondin-1. Angiogenesis in Health and Disease: Basic Mechanisms and Clinical Applications : 349-357. antiangiogenic1999
Iruela-Arispe, M.L., Vazquez, F., and Ortega, M.A.. 1999. Anti-angiogenic domains shared by thrombospondins and metallospondins, a new family of angiogenic inhibitors. Ann. N.Y. Acad. Sci 886: 58-66.
Iruela-Arispe, M.L., Lombardo, M., Krutzsch, H.C., Lawler, J., and Roberts, D.D.. 1999. Inhibition of angiogenesis by thrombospondin-1 is mediated by two independent regions within the type1 repeats. Circulation 100: 1423-1431.
Wu. H., Lee, S.H., Jing Gao, Xin Liu, and Iruela-Arispe, M.L.. 1999. Inactivation of erythropoetin leads to defects in cardiac morphogenesis. Development 126: 3597-3605.
Vazquez, F., Hasting, G., Ortega, M.A., Lane, T.F., Oikemus, S., Lombardo, M., and Iruela-Arispe, M.L.. 1999. METH1 a human ortholog of ADAMTS, and METH2 are members of a new family of proteins with angio-inhibitory activity. J. Bio. Chem 274: 23349-23357.
Zhai, Y., Yu, L., Iruela- Arispe, L., Huang, W.Q., Wang, Z., Hayes, A.J., Lu, J., Jaing, G., Rojas, L., Lippman, M.E., Ni, J., Yu, G.L., and Li, L.Y.. 1999. Inhibition of angiogenesis and breast cancer xenograft tumor by VEGI, a novel cytokine of the TNF superfamily. Int. J. Cancer 82: 131-136.
Brown, L.F., Guidi, A.J., Schnitt, S.J., Van De Water, L., Iruela- Arispe, M.L., Yeu, T.K., Tognassi, K., Dvorak, H.F.. 1999. Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin. Cancer Res 5: 1041-1056.
Iruela-Arispe, M.L., Rodriguez- Manzaneque, and Abu-Jawdeh, G.. 1999. Endometrical endothelial cells express estrogen and progesterone receptors and exhibit a tissue specific response to antiogenic growth factors. Microcirculation 6: 127-140.
Dhanabal, M., Ramchandran, R., Volk, R., Stillman, I.E., Lombardo, M., Iruela-Arispe, M.L., Simons, M., and Sukhatme, V.P.. 1999. Endostatin: yeast production, mutants, and anti-tumor effect in renal cell carcinoma. Cancer Res 59: 189-197.
Vazquez, F., Rodriguez-Manzaneque, J.C., Lydon, J.P., Edwards, D.P., O’Malley B.W., and Iruela-Arispe, M.L.. 1999. Progesterone regulates proliferation of endothelial cells. J. Biol. Chem 274: 2185-2192.
Lee, S.H.,Hungerford, J.E., Little, C.D. and Iruela-Arispe, M.L.. 1997. Proliferation and differentiation of smooth muscle cell precursors occurs simultaneously during the development of the vessel wall. Dev. Dyn 209: 342-352.
Iruela-Arispe, M.L. and Dvorak, H.F.. 1997. Angiogenesis: A dynamic balance of stimulator and inhibitors. Thromb. Haem 78: 672-677. Thromb.Haem78(1)672(1997)
Iruela-Arispe, M.L.. 1997. Normal placentation: A tale that requires an epithelial-to-endothelial conversion. J. Clin.Invest 99: 2057-2058.
Brown, L.F., Demar, M., Tognazzi, K., Abu-Jawdeh., G. and Iruela-Arispe, M.L.. 1997. Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor (vascular endothelial growth factor). Lab. Invest 76: 245-255. Brown_Lab Invest_76(1997)f
Luther, T., Flossel, C., Mackman, N., Bierhaus, A., Kasper, M., Albrecht, S., Sage, E.H., Iruela-Arispe, L., Grossmann, H., Strohlein, A., Zhang, Y., Nawroth, P.P., Carmeliet, P., Loskutoff, D.J., and Mueller, M.. 1996. Tissue factor expression during human and mouse development. Am. J. Pathol 149: 101-113. Luther_AJP_149(1996)
Iruela-Arispe, M.L., Vernon, R.B., Wu, H., Jaenish, R., and Sage, E.H.. 1996. Type I collagen-deficient mov 13 mice do not retain SPARC in the extracellular matrix: Implications for fibroblast function. Dev. Dyn 207: 171-183.
Gariano, R.F., Iruela-Arispe M.L., Sage, E. H., and Hendrickson, A.E.. 1996. Immunohistochemical characterization of developing and mature primate retinal blood vessels. Invest. Ophthalmol. & Visual Science 37: 93-103.
Iruela-Arispe, M.L., Porter, P., Bornstein, P., and Sage E.H.. 1996. Thrombospondin-1, an inhibitor of angiogenesis, is regulated by progesterone in human endometrium. J. Clin. Invest 97: 403-412. PMCID: PMC507031
Iruela-Arispe, L., Gordon, K., Hugo, C., Duijvestijn, A. M. Claffey, K.P., Reilly, M., Couser, W. G., Alpers, C.E. and Johnson, R.J.. 1995. Participation of glomerular endothelial cells in the capillary repair of glomerulonephritis. Am. J. Pathol 147: 1715-1728. PMCID: PMC1869935
Reed, M.J., Iruela-Arispe, M.L., O’ Brein, E.R., Truong, T., LaBell, T., Bornstein, P., and Sage E.H.. 1995. Expression of thrombospondins by endotheial cells: injury is correlated with TSP1. Am. J. Pathol 147: 1068-1080. PMCID: PMC1870996
Seiffert, D., Iruela-Arispe, M.L., Sage, E.H., and Loskutoff, D.J.. 1995. Distribution of vitronectin mRNA during murine development. Dev. Dyn 203: 71-79.
Vernon, R.B., Lara, S.L., Drake, C.J., Iruela-Arispe, M.L., Angello J.C., Little, C.D., Wight, T.N. and Sage, E.H.. 1995. Organized Type I collagen influences endothelial patterns during “spontaneous angiogenesis in vitro”: planar cultures as models of vascular development. Cell Dev. Biol 31: 120-131.
Iruela-Arispe, M.L., Lane, T.F., Redmond, D., Reilly, M., Bolender, R., and Kavanaugh, T.J. and Sage E.H.. 1995. Expression of SPARC during the development of the chorioallantoic membrane: evidence for regulated proteolysis in vivo. Mol. Biol. Cell 6: 327-343. PMCID: PMC301191
Gariano, R.F., Iruela-Arispe, M.L. and Hendrickson, A.E.. 1994. Vascular Development in the primate retina: Comparison of laminar plexus formation in monkey and human. Invest. Ophtal. Vis. Sci 35: 3442-3455.
Lane, T.F., Iruela-Arispe, M.L., Johnson, R.S. and Sage, E.H.. 1994. SPARC is a source of copper-binding peptides that stimulate angiogenesis. J. Cell Biol 125: 929-943. PMCID: PMC2120067
Battegay, E. J., Rupp, J., Iruela-Arispe, M.L., Sage, E.H., and Pech, M.. 1994. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGFB-receptors. J. Cell Biol 125: 917-928. PMCID: PMC2120083
Iruela-Arispe, M.L.,Liska, D.A., Sage, E.H. and Borenstein, P.. 1994. Differential of Expression of Thrombospondin 1, 2, an 3 during Murine Development. Dev. Dyn 197: 40-56.
Bassuk, J.A., Iruela-Arispe, M.L., Lane, T.F., Benson, J. M., Berg, R.A., and Sage, E.H.. 1993. Molecular analysis of chicken embryo SPARC. Europ. J Biochem 218: 117-127.
Iruela-Arispe, M.L., and Sage, E.H.. 1993. Endothelial Cells Exhibiting Angiogenesis In vitro Proliferate in Response to TGF-B1. J. Cell. Biochem 52: 414-430. Arispe_JCBiochem_52(1993)
Floege, J., Johnson, R.J., Gordon, K., Yoshimura, A., Campell, C., Iruela-Arispe, M.L., Alpers, C.E., Couser, W.G.. 1992. Altered Glomerular Extracellular Matrix Synthesis in Experimental Membranous Nephropathy. Kidney Int 42: 573-585. Floege_kidney.int_42(1992)
Javelainen, H.T., Iruela-Arispe, M.L., Kinsella, M.G. Sandell, L.J., Sage, E.H., and Wight, T.N.. 1992. Expression of decorin by sprouting bovine aortic endothelial cells exhibiting angiogenesis in Vitro. Exp. Cell Res 203: 395-401. Jarvelainen_Exp.Cell.Res203(1992)
Sage, E.H., Lane, T.F., Iruela-Arispe, M.L. and Funk, S.E.. 1992. A Protein that Modulates Cell Cycle and Cell-matrix Interactions. Proc. Forth Int’l Conf. Chem. Biol. Mineraliz. Tiss : 235-242. Sage_235-42(1992)
Lane, T., Iruela-Arispe, M.L. and Sage, E.H.. 1992. Regulation of Gene Expression by SPARC during Angiogenesis in vitro: Changes in Fibronectin, Thrombospondin- 1, and Plasminogen Activator Inhibitor- 1. J. Bio. Chem 267: 16736-16745.
Vernon R.B., Angello, J.C., Iruela-Arispe, M.L., Lane, T.F., and Sage E.H.. 1992. Reorganization of Basement Membrane Matrices by Cellular Traction Promotes the Formation of Cellular Networks in vitro. Lab. Invest 66: 536-547. Vernon_LabInvest_66(1992)
Iruela-Arispe, M.L., Chun, L., and Sage, E. H.. 1992. Structure and Biology of Type VIII Collagen. Trends Glycosci. Glycotechnol 4: 188-199. Arispe_Glycosci.Glycotech_4(1992)
Raines, E.W., Lane, T., Iruela-Arispe, M.L.,Ross, R., and Sage, E.H.. 1992. The Extracellular Glycoprotein SPARC Interacts with Platelet-derived Growth Factor (PDGF)-AB and BB and Inhibits Binding of PDGF to its Receptors. Proc. Natl.Acad. Sci 89: 1281-1285. PMCID: PMC48433
Iruela-Arispe, M.L., Diglio, C.A. and Sage, E.H.. 1991. Modulation of Extracellular Matrix Proteins by Endothelial Cells undergoing Angiogenesis in vitro. Arterioscler. Thromb 11: 805-815.
Fouser, L., Iruela-Arispe, M.L., Borstein, P., and Sage, E.H.. 1991. Transcriptional Activity of the alpha 1(I)-Collagen Promoter in Endothelial Cells is Correlated with the Formation of Capillary-like Structures by Endothelial Cells in Vitro. J. Biol. Chem 266: 18345-18351.
Iruela-Arispe, M.L., Bornstein, P., and Sage, H.. 1991. Thrombospondin Exerts an Antiangiogenic Effect on Tube Formation by Endothelial Cells in vitro. Proc. Natl. Acad. Sci 88: 5026-5030. PMCID: PMC51800
Iruela-Arispe, M.L., and Sage, H.. 1991. Expression of Type VIII Collagen during Morphogenesis of the Chicken and Mouse Heart. Dev. Biol 144: 107-118.
Paulus, W., Sage, H., Liszka, U., Iruela-Arispe, M.L. and Jellinger, K.. 1991. Increased levels of type VIII collagen in human brain tumours compared to normal brain tissue and non-neoplastic cerebral disorders. Brit. J. Cancer 63: 367-371. PMCID: PMC1971869
Iruela-Arispe, M.L. Hasselaar, P., Sage, H.. 1990. Differential Expression of Extracellular Proteins is correlated with Angiogenesis in vitro. Lab. Invest 64: 174-186. Arispe_lab.inv_64(1991)
Sage, H. and Iruela-Arispe, M.L.. 1990. Type VIII Collagen in Murine Development. Association with Capillary Formation in vitro. Structure, Molecular Biology and Pathology of Collagen 580: 17-31.
1980s
Sage, H., Vernon, R.D., Decker, J., Funk, S., and Iruela-Arispe, M.L.. 1989. Distribution of the Calcium-binding Protein SPARC in Tissues of Embryonic and Adult Mice. J. Histochem. Cytochem 37: 819-829.
Chow, M., Boyd, C.D., Iruela-Arispe, M.L., Wrenn, D.S., Mecham, R., and Sage, H.. 1989. Characterization of Elastin Protein and mRNA from Salmonid Fish (Oncorhynchus kisutch). Comp. Biochem. Physiol 93: 835-845. Chow_Comp.Bioch.Phys_93B(1989)
Cotta-Pereira, G. and Iruela-Arispe, M.L.. 1989. Extracellular matrix: Functional significance of oxytalan, elaunin and elastic fibers. Cells and Tissues: A Three Dimensional Approach by Modern Techniques in Microscopy : 61-67. cells_tissues(1989)
Cotta-Pereira, G. and Iruela-Arispe, M.L.. 1988. Extracurricular Matrix: Functional Significance of Oxytalan, Elaunin and Elastic Fibers. Quaderni di Anatomia Practica 295:101-7.
