John Adams
Dr. Adams has been continually funded by the NIH for the last 40 years to do translational research in the field of vitamin D synthesis, metabolism and action. Adams’ current research portfolio includes: 1] the molecular biology of chromatin remodeling, transcription, splicing and miRNA action in response to sterol/steroid hormones; 2] the role of alternative splicing in determining stem cell fates in bone; 3] innate and adaptive molecular and cellular immunity with regard to vitamin D and its metabolites; 4] the translational aspects of human macrophage and neutrophil anti-microbial actions; 5] the impact of human vitamin D deficiency on innate immune-responsivity to microbes from orthopaedic implant infections and prosthetic wear debris; and 6] actions of vitamin D on the human musculoskeletal system in health and disease. He is the author of over 190 peer-reviewed publications in his field in the foremost scientific and biomedical research journals, including Nature, Science, Cell and the New England Journal of Medicine. Dr. Adams is an editor of the third edition of the signature text in his field, Vitamin D, and is on the editorial boards of the newest journals in his field, Bone Research and Journal of the Endocrine Society. He also serves on the consulting editorial board for the Journal of Clinical Investigation. Dr, Adams is i) founding and current Director of the UCLA-Orthopaedic Hospital Research Center, ii) Vice Chair for Research in the UCLA Department of Orthopaedic Surgery, iii) founding Principal Investigator of the NIAMS-funded Orthopaedic T32 at UCLA, iv) founding and current Associate Director of the UCLA Clinical and Translation Science Institute (CTSI; CTSA to UCLA), v) founding Director of the California Institute for Regenerative Medicine-funded UCLA Alpha Stem Cell Clinic, and vi) Assistant Dean for Translational Research. Collectively, these programs are designed to open up new transdisiplinary opportunities for precedent-setting research in the field of translational science for senior and junior investigators, particularly surgeon scientists during the formative stages of their independent research career. Dr. Adams has a long and successful track record in training undergraduate, graduate, postdoctoral and medical students as well as junior faculty for careers in research under the auspices of extramural funding from the NIH. In his laboratory and translational research program over the past ten years Dr. Adams has trained; i) 18 undergraduates (including three Hispanics and two African Americans), ten of whom have applied to or entered medical school and seven of whom have entered graduate school, ii) ten graduate students (including two Hispanics), all of whom have matriculated to post-doctoral fellowships or medical school, iii) ten postdoctoral fellows (including one Pacific Islander), nine of whom have taken jobs in academia or industry and iv) three medical students (including one Hispanic). During this same ten-year period Dr. Adams has served as mentor for eight junior faculty on NIH- and VA- supported career development awards..
Websites:
Jonsson Comprehensive Cancer Center
Clinical and Translational Science Institute (CTSI)
Graduate Programs in Bioscience
Orthopaedic Surgery
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research
Research Interests:
impact of human vitamin D deficiency on innate immune-responsivity to microbes from orthopaedic, translational aspects of human macrophage and neutrophil anti-microbial actions, role of alternative splicing in determining stem cell fates in bone, vitamin D metabolism and action, actions of vitamin D on the human musculoskeletal system in health and disease, innate and adaptive molecular and cellular immunity with regard to vitamin D and its metabolites,Publications:
Henrich M, Ha P, Wang Y, Ting K, Stodieck L, Soo C, Adams JS, Chun R. Alternative splicing diversifies the skeletal muscle transcriptome during prolonged spaceflight. Skelet Muscle. 2022 05 31; 12(1):11. view on PubMed
Shieh A, Lee SM, Lagishetty V, Gottleib C, Jacobs JP, Adams JS. Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome? J Clin Endocrinol Metab. 2021 11 19; 106(12):3464-3476. view on PubMed
James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. Author Correction: NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2021 Jan 13; 12(1):453. view on PubMed
Thomas RL, Jiang L, Adams JS, Xu ZZ, Shen J, Janssen S, Ackermann G, Vanderschueren D, Pauwels S, Knight R, Orwoll ES, Kado DM. Vitamin D metabolites and the gut microbiome in older men. Nat Commun. 2020 11 26; 11(1):5997. view on PubMed
Zhao G, Kim EW, Jiang J, Bhoot C, Charles KR, Baek J, Mohan S, Adams JS, Tetradis S, Lyons KM. CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH. J Bone Miner Res. 2020 11; 35(11):2289-2300. view on PubMed
Arshi A, Shieh A, Adams JS, Bernthal NM, Zeegen EN, Sassoon AA. Preoperative Vitamin D Repletion in Total Knee Arthroplasty: A Cost-Effectiveness Model. J Arthroplasty. 2020 05; 35(5):1379-1383. view on PubMed
Chun RF, Shieh A, Gottlieb C, Yacoubian V, Wang J, Hewison M, Adams JS. Vitamin D Binding Protein and the Biological Activity of Vitamin D. Front Endocrinol (Lausanne). 2019; 10:718. view on PubMed
Li D, Jeffery LE, Jenkinson C, Harrison SR, Chun RF, Adams JS, Raza K, Hewison M. Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis. J Steroid Biochem Mol Biol. 2019 03; 187:1-8. view on PubMed
Zavala K, Gottlieb CA, Teles RM, Adams JS, Hewison M, Modlin RL, Liu PT. Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN. PLoS Negl Trop Dis. 2018 10; 12(10):e0006815. view on PubMed
Shieh A, Ma C, Chun RF, Wittwer-Schegg J, Swinkels L, Huijs T, Wang J, Donangelo I, Hewison M, Adams JS. Associations Between Change in Total and Free 25-Hydroxyvitamin D With 24,25-Dihydroxyvitamin D and Parathyroid Hormone. J Clin Endocrinol Metab. 2018 09 01; 103(9):3368-3375. view on PubMed
Jamieson CHM, Millan MT, Creasey AA, Lomax G, Donohoe ME, Walters MC, Abedi M, Bota DA, Zaia JA, Adams JS. CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges. Cell Stem Cell. 2018 06 01; 22(6):801-805. view on PubMed
Hegde V, Arshi A, Wang C, Buser Z, Wang JC, Jensen AR, Adams JS, Zeegen EN, Bernthal NM. Preoperative Vitamin D Deficiency Is Associated With Higher Postoperative Complication Rates in Total Knee Arthroplasty. Orthopedics. 2018 Jul 01; 41(4):e489-e495. view on PubMed
Hegde V, Dworsky EM, Stavrakis AI, Loftin AH, Zoller SD, Park HY, Richman S, Johansen D, Hu Y, Taylor JA, Hamad CD, Chun RF, Xi W, Adams JS, Bernthal NM. Single-Dose, Preoperative Vitamin-D Supplementation Decreases Infection in a Mouse Model of Periprosthetic Joint Infection. J Bone Joint Surg Am. 2017 Oct 18; 99(20):1737-1744. view on PubMed
Shieh A, Ma C, Chun RF, Witzel S, Rafison B, Contreras HTM, Wittwer-Schegg J, Swinkels L, Huijs T, Hewison M, Adams JS. Effects of Cholecalciferol vs Calcifediol on Total and Free 25-Hydroxyvitamin D and Parathyroid Hormone. J Clin Endocrinol Metab. 2017 Apr 01; 102(4):1133-1140. view on PubMed
Zhou R, Park JW, Chun RF, Lisse TS, Garcia AJ, Zavala K, Sea JL, Lu ZX, Xu J, Adams JS, Xing Y, Hewison M. Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells. Nucleic Acids Res. 2017 01 25; 45(2):606-618. view on PubMed
Chun RF, Hernandez I, Pereira R, Swinkles L, Huijs T, Zhou R, Liu NQ, Shieh A, Guemes M, Mallya SM, Adams JS, Hewison M. Differential Responses to Vitamin D2 and Vitamin D3 Are Associated With Variations in Free 25-Hydroxyvitamin D. Endocrinology. 2016 09; 157(9):3420-30. view on PubMed
Shieh A, Chun RF, Ma C, Witzel S, Meyer B, Rafison B, Swinkels L, Huijs T, Pepkowitz S, Holmquist B, Hewison M, Adams JS. Effects of High-Dose Vitamin D2 Versus D3 on Total and Free 25-Hydroxyvitamin D and Markers of Calcium Balance. J Clin Endocrinol Metab. 2016 08; 101(8):3070-8. view on PubMed
Nielson CM, Jones KS, Chun RF, Jacobs JM, Wang Y, Hewison M, Adams JS, Swanson CM, Lee CG, Vanderschueren D, Pauwels S, Prentice A, Smith RD, Shi T, Gao Y, Schepmoes AA, Zmuda JM, Lapidus J, Cauley JA, Bouillon R, Schoenmakers I, Orwoll ES, Osteoporotic Fractures in Men (MrOS) Research Group. Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations. J Clin Endocrinol Metab. 2016 05; 101(5):2226-34. view on PubMed
Nielson CM, Jones KS, Bouillon R, Osteoporotic Fractures in Men (MrOS) Research Group, Chun RF, Jacobs J, Wang Y, Hewison M, Adams JS, Swanson CM, Lee CG, Vanderschueren D, Pauwels S, Prentice A, Smith RD, Shi T, Gao Y, Zmuda JM, Lapidus J, Cauley JA, Schoenmakers I, Orwoll ES. Role of Assay Type in Determining Free 25-Hydroxyvitamin D Levels in Diverse Populations. N Engl J Med. 2016 Apr 28; 374(17):1695-6. view on PubMed
Jenkinson C, Taylor AE, Hassan-Smith ZK, Adams JS, Stewart PM, Hewison M, Keevil BG. High throughput LC-MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 01; 1014:56-63. view on PubMed
James AW, Shen J, Zhang X, Asatrian G, Goyal R, Kwak JH, Jiang L, Bengs B, Culiat CT, Turner AS, Seim Iii HB, Wu BM, Lyons K, Adams JS, Ting K, Soo C. NELL-1 in the treatment of osteoporotic bone loss. Nat Commun. 2015 Jun 17; 6:7362. view on PubMed
Lake JE, Hoffman RM, Tseng CH, Wilhalme HM, Adams JS, Currier JS. Success of Standard Dose Vitamin D Supplementation in Treated Human Immunodeficiency Virus Infection. Open Forum Infect Dis. 2015 Apr; 2(2):ofv068. view on PubMed
Wu L, Petrigliano FA, Ba K, Lee S, Bogdanov J, McAllister DR, Adams JS, Rosenthal AK, Van Handel B, Crooks GM, Lin Y, Evseenko D. Lysophosphatidic acid mediates fibrosis in injured joints by regulating collagen type I biosynthesis. Osteoarthritis Cartilage. 2015 Feb; 23(2):308-18. view on PubMed
Zhou R, Chun RF, Lisse TS, Garcia AJ, Xu J, Adams JS, Hewison M. Vitamin D and alternative splicing of RNA. J Steroid Biochem Mol Biol. 2015 Apr; 148:310-7. view on PubMed
Chun RF, Blatter E, Elliott S, Fitz-Gibbon S, Rieger S, Sagasti A, Adams JS, Hewison M. Cloning of a functional 25-hydroxyvitamin D-1α-hydroxylase in zebrafish (Danio rerio). Cell Biochem Funct. 2014 Dec; 32(8):675-82. view on PubMed
Montoya D, Inkeles MS, Liu PT, Realegeno S, Teles RM, Vaidya P, Munoz MA, Schenk M, Swindell WR, Chun R, Zavala K, Hewison M, Adams JS, Horvath S, Pellegrini M, Bloom BR, Modlin RL. IL-32 is a molecular marker of a host defense network in human tuberculosis. Sci Transl Med. 2014 Aug 20; 6(250):250ra114. view on PubMed
Chun RF, Liu NQ, Lee T, Schall JI, Denburg MR, Rutstein RM, Adams JS, Zemel BS, Stallings VA, Hewison M. Vitamin D supplementation and antibacterial immune responses in adolescents and young adults with HIV/AIDS. J Steroid Biochem Mol Biol. 2015 Apr; 148:290-7. view on PubMed
Chun RF, Liu PT, Modlin RL, Adams JS, Hewison M. Impact of vitamin D on immune function: lessons learned from genome-wide analysis. Front Physiol. 2014; 5:151. view on PubMed
Yuan FN, Valiyaparambil J, Woods MC, Tran H, Pant R, Adams JS, Mallya SM. Vitamin D signaling regulates oral keratinocyte proliferation in vitro and in vivo. Int J Oncol. 2014 May; 44(5):1625-33. view on PubMed
Lisse TS, Vadivel K, Bajaj SP, Chun RF, Hewison M, Adams JS. The heterodimeric structure of heterogeneous nuclear ribonucleoprotein C1/C2 dictates 1,25-dihydroxyvitamin D-directed transcriptional events in osteoblasts. Bone Res. 2014; 2. view on PubMed
Adams JS, Rafison B, Witzel S, Reyes RE, Shieh A, Chun R, Zavala K, Hewison M, Liu PT. Regulation of the extrarenal CYP27B1-hydroxylase. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:22-7. view on PubMed
Chun RF, Peercy BE, Orwoll ES, Nielson CM, Adams JS, Hewison M. Vitamin D and DBP: the free hormone hypothesis revisited. J Steroid Biochem Mol Biol. 2014 Oct; 144 Pt A:132-7. view on PubMed
Wu L, Gonzalez S, Shah S, Kyupelyan L, Petrigliano FA, McAllister DR, Adams JS, Karperien M, Tuan TL, Benya PD, Evseenko D. Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy. Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. view on PubMed
Lisse TS, Chun RF, Rieger S, Adams JS, Hewison M. Vitamin D activation of functionally distinct regulatory miRNAs in primary human osteoblasts. J Bone Miner Res. 2013 Jun; 28(6):1478-88. view on PubMed
Teles RM, Graeber TG, Krutzik SR, Montoya D, Schenk M, Lee DJ, Komisopoulou E, Kelly-Scumpia K, Chun R, Iyer SS, Sarno EN, Rea TH, Hewison M, Adams JS, Popper SJ, Relman DA, Stenger S, Bloom BR, Cheng G, Modlin RL. Type I interferon suppresses type II interferon-triggered human anti-mycobacterial responses. Science. 2013 Mar 22; 339(6126):1448-53. view on PubMed
Bacchetta J, Sea JL, Chun RF, Lisse TS, Wesseling-Perry K, Gales B, Adams JS, Salusky IB, Hewison M. Fibroblast growth factor 23 inhibits extrarenal synthesis of 1,25-dihydroxyvitamin D in human monocytes. J Bone Miner Res. 2013 Jan; 28(1):46-55. view on PubMed
Adams JS, Ramin J, Rafison B, Windon C, Windon A, Liu PT. Redefining Human Vitamin D Sufficiency: Back to the Basics. Bone Res. 2013; 1(1):2-10. view on PubMed
Lisse TS, Adams JS, Hewison M. Vitamin D and microRNAs in bone. Crit Rev Eukaryot Gene Expr. 2013; 23(3):195-214. view on PubMed
Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, Murad MH, Kovacs CS. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev. 2012 Jun; 33(3):456-92. view on PubMed
Adams JS, Hewison M. Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase. Arch Biochem Biophys. 2012 Jul 01; 523(1):95-102. view on PubMed
James AW, Pang S, Askarinam A, Corselli M, Zara JN, Goyal R, Chang L, Pan A, Shen J, Yuan W, Stoker D, Zhang X, Adams JS, Ting K, Soo C. Additive effects of sonic hedgehog and Nell-1 signaling in osteogenic versus adipogenic differentiation of human adipose-derived stromal cells. Stem Cells Dev. 2012 Aug 10; 21(12):2170-8. view on PubMed
Billi F, Benya P, Kavanaugh A, Adams J, McKellop H, Ebramzadeh E. The John Charnley Award: an accurate and extremely sensitive method to separate, display, and characterize wear debris: part 2: metal and ceramic particles. Clin Orthop Relat Res. 2012 Feb; 470(2):339-50. view on PubMed
Billi F, Benya P, Kavanaugh A, Adams J, Ebramzadeh E, McKellop H. The John Charnley Award: an accurate and sensitive method to separate, display, and characterize wear debris: part 1: polyethylene particles. Clin Orthop Relat Res. 2012 Feb; 470(2):329-38. view on PubMed
Chun RF, Peercy BE, Adams JS, Hewison M. Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling. PLoS One. 2012; 7(1):e30773. view on PubMed
Fabri M, Stenger S, Shin DM, Yuk JM, Liu PT, Realegeno S, Lee HM, Krutzik SR, Schenk M, Sieling PA, Teles R, Montoya D, Iyer SS, Bruns H, Lewinsohn DM, Hollis BW, Hewison M, Adams JS, Steinmeyer A, Zügel U, Cheng G, Jo EK, Bloom BR, Modlin RL. Vitamin D is required for IFN-gamma-mediated antimicrobial activity of human macrophages. Sci Transl Med. 2011 Oct 12; 3(104):104ra102. view on PubMed
Chun RF, Adams JS, Hewison M. Immunomodulation by vitamin D: implications for TB. Expert Rev Clin Pharmacol. 2011 Sep; 4(5):583-91. view on PubMed
Lake JE, Adams JS. Vitamin D in HIV-Infected Patients. Curr HIV/AIDS Rep. 2011 Sep; 8(3):133-41. view on PubMed
Zou X, Shen J, Chen F, Ting K, Zheng Z, Pang S, Zara JN, Adams JS, Soo C, Zhang X. NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation. FEBS Lett. 2011 Aug 04; 585(15):2410-8. view on PubMed
Walker VP, Zhang X, Rastegar I, Liu PT, Hollis BW, Adams JS, Modlin RL. Cord blood vitamin D status impacts innate immune responses. J Clin Endocrinol Metab. 2011 Jun; 96(6):1835-43. view on PubMed
Lisse TS, Hewison M, Adams JS. Hormone response element binding proteins: novel regulators of vitamin D and estrogen signaling. Steroids. 2011 Mar; 76(4):331-9. view on PubMed
Edfeldt K, Liu PT, Chun R, Fabri M, Schenk M, Wheelwright M, Keegan C, Krutzik SR, Adams JS, Hewison M, Modlin RL. T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22593-8. view on PubMed
Lisse TS, Liu T, Irmler M, Beckers J, Chen H, Adams JS, Hewison M. Gene targeting by the vitamin D response element binding protein reveals a role for vitamin D in osteoblast mTOR signaling. FASEB J. 2011 Mar; 25(3):937-47. view on PubMed
Bernthal NM, Stavrakis AI, Billi F, Cho JS, Kremen TJ, Simon SI, Cheung AL, Finerman GA, Lieberman JR, Adams JS, Miller LS. A mouse model of post-arthroplasty Staphylococcus aureus joint infection to evaluate in vivo the efficacy of antimicrobial implant coatings. PLoS One. 2010 Sep 07; 5(9):e12580. view on PubMed
Hokugo A, Christensen R, Chung EM, Sung EC, Felsenfeld AL, Sayre JW, Garrett N, Adams JS, Nishimura I. Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats. J Bone Miner Res. 2010 Jun; 25(6):1337-49. view on PubMed
Lagishetty V, Misharin AV, Liu NQ, Lisse TS, Chun RF, Ouyang Y, McLachlan SM, Adams JS, Hewison M. Vitamin D deficiency in mice impairs colonic antibacterial activity and predisposes to colitis. Endocrinology. 2010 Jun; 151(6):2423-32. view on PubMed
Lagishetty V, Chun RF, Liu NQ, Lisse TS, Adams JS, Hewison M. 1alpha-hydroxylase and innate immune responses to 25-hydroxyvitamin D in colonic cell lines. J Steroid Biochem Mol Biol. 2010 Jul; 121(1-2):228-33. view on PubMed
Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab. 2010 Feb; 95(2):471-8. view on PubMed
Hewison M, Adams JS. Vitamin D insufficiency and skeletal development in utero. J Bone Miner Res. 2010 Jan; 25(1):11-3. view on PubMed
Montoya D, Cruz D, Teles RM, Lee DJ, Ochoa MT, Krutzik SR, Chun R, Schenk M, Zhang X, Ferguson BG, Burdick AE, Sarno EN, Rea TH, Hewison M, Adams JS, Cheng G, Modlin RL. Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe. 2009 Oct 22; 6(4):343-53. view on PubMed
Adams JS, Ren S, Liu PT, Chun RF, Lagishetty V, Gombart AF, Borregaard N, Modlin RL, Hewison M. Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. J Immunol. 2009 Apr 01; 182(7):4289-95. view on PubMed
Chen H, Clemens TL, Hewison M, Adams JS. Estradiol and tamoxifen mediate rescue of the dominant-negative effects of estrogen response element-binding protein in vivo and in vitro. Endocrinology. 2009 May; 150(5):2429-35. view on PubMed
Krutzik SR, Hewison M, Liu PT, Robles JA, Stenger S, Adams JS, Modlin RL. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J Immunol. 2008 Nov 15; 181(10):7115-20. view on PubMed
Lee JM, Pou K, Sadow PM, Chen H, Hu B, Hewison M, Adams JS, Sugarbaker DJ, Fisher ND. Vitamin D-mediated hypercalcemia and Cushing syndrome as manifestations of malignant pleural mesothelioma. Endocr Pract. 2008 Nov; 14(8):1011-6. view on PubMed
Liu N, Nguyen L, Chun RF, Lagishetty V, Ren S, Wu S, Hollis B, DeLuca HF, Adams JS, Hewison M. Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation. Endocrinology. 2008 Oct; 149(10):4799-808. view on PubMed
Chun RF, Adams JS, Hewison M. Back to the future: a new look at 'old' vitamin D. J Endocrinol. 2008 Aug; 198(2):261-9. view on PubMed
Geller JL, Hu B, Reed S, Mirocha J, Adams JS. Increase in bone mass after correction of vitamin D insufficiency in bisphosphonate-treated patients. Endocr Pract. 2008 Apr; 14(3):293-7. view on PubMed
Geller JL, Adams JS. Vitamin D therapy. Curr Osteoporos Rep. 2008 Mar; 6(1):5-11. view on PubMed
Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab. 2008 Feb; 4(2):80-90. view on PubMed
Chen H, Hewison M, Adams JS. Control of estradiol-directed gene transactivation by an intracellular estrogen-binding protein and an estrogen response element-binding protein. Mol Endocrinol. 2008 Mar; 22(3):559-69. view on PubMed
Adams JS, Chen H, Chun R, Ren S, Wu S, Gacad M, Nguyen L, Ride J, Liu P, Modlin R, Hewison M. Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response. J Bone Miner Res. 2007 Dec; 22 Suppl 2:V20-4. view on PubMed
Adams JS, Liu PT, Chun R, Modlin RL, Hewison M. Vitamin D in defense of the human immune response. Ann N Y Acad Sci. 2007 Nov; 1117:94-105. view on PubMed
Geller JL, Khosravi A, Kelly MH, Riminucci M, Adams JS, Collins MT. Cinacalcet in the management of tumor-induced osteomalacia. J Bone Miner Res. 2007 Jun; 22(6):931-7. view on PubMed
Geller JL, Adams JS. Proton pump inhibitor therapy and hip fracture risk. JAMA. 2007 Apr 04; 297(13):1429; author reply 1429-30. view on PubMed
Hewison M, Burke F, Evans KN, Lammas DA, Sansom DM, Liu P, Modlin RL, Adams JS. Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease. J Steroid Biochem Mol Biol. 2007 Mar; 103(3-5):316-21. view on PubMed
Chen H, Hewison M, Adams JS. Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding protein. J Biol Chem. 2006 Dec 22; 281(51):39114-20. view on PubMed
Karakelides H, Geller JL, Schroeter AL, Chen H, Behn PS, Adams JS, Hewison M, Wermers RA. Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylase. J Bone Miner Res. 2006 Sep; 21(9):1496-9. view on PubMed
Geller JL, Adams JS. Statins and fracture: are all variables accounted for? Arch Intern Med. 2006 May 08; 166(9):1041; author reply 1041-2. view on PubMed
Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, Ochoa MT, Schauber J, Wu K, Meinken C, Kamen DL, Wagner M, Bals R, Steinmeyer A, Zügel U, Gallo RL, Eisenberg D, Hewison M, Hollis BW, Adams JS, Bloom BR, Modlin RL. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006 Mar 24; 311(5768):1770-3. view on PubMed
Equils O, Naiki Y, Shapiro AM, Michelsen K, Lu D, Adams J, Jordan S. 1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immunol. 2006 Jan; 143(1):58-64. view on PubMed
Abreu MT, Geller JL, Vasiliauskas EA, Kam LY, Vora P, Martyak LA, Yang H, Hu B, Lin YC, Keenan G, Price J, Landers CJ, Adams JS, Targan SR. Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease. J Clin Gastroenterol. 2006 Jan; 40(1):55-63. view on PubMed
Adams JS. "Bound" to work: the free hormone hypothesis revisited. Cell. 2005 Sep 09; 122(5):647-9. view on PubMed
Chun R, Gacad MA, Hewison M, Adams JS. Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperones. Endocrinology. 2005 Dec; 146(12):5540-4. view on PubMed
Townsend K, Evans KN, Campbell MJ, Colston KW, Adams JS, Hewison M. Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment. J Steroid Biochem Mol Biol. 2005 Oct; 97(1-2):103-9. view on PubMed
Chen H, Stuart W, Hu B, Nguyen L, Huang G, Clemens TL, Adams JS. Creation of estrogen resistance in vivo by transgenic overexpression of the heterogeneous nuclear ribonucleoprotein-related estrogen response element binding protein. Endocrinology. 2005 Oct; 146(10):4266-73. view on PubMed
Ren S, Nguyen L, Wu S, Encinas C, Adams JS, Hewison M. Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis. J Biol Chem. 2005 May 27; 280(21):20604-11. view on PubMed
Evans KN, Taylor H, Zehnder D, Kilby MD, Bulmer JN, Shah F, Adams JS, Hewison M. Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy. Am J Pathol. 2004 Sep; 165(3):807-13. view on PubMed
Adams JS, Chen H, Chun R, Gacad MA, Encinas C, Ren S, Nguyen L, Wu S, Hewison M, Barsony J. Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism. J Steroid Biochem Mol Biol. 2004 May; 89-90(1-5):461-5. view on PubMed
Chen H, Hewison M, Hu B, Sharma M, Sun Z, Adams JS. An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein. J Biol Chem. 2004 Jul 16; 279(29):29944-51. view on PubMed
Hewison M, Zehnder D, Chakraverty R, Adams JS. Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase. Mol Cell Endocrinol. 2004 Feb 27; 215(1-2):31-8. view on PubMed
Li X, Chen S, Kantorovich V, Cheng LS, Cohn DH, Rotter JI, Yang H, Adams JS. Genetic determinants of osteoporosis susceptibility in a female Ashkenazi Jewish population. Genet Med. 2004 Jan-Feb; 6(1):33-7. view on PubMed
Chen H, Hewison M, Hu B, Adams JS. Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6109-14. view on PubMed
Hewison M, Kantorovich V, Liker HR, Van Herle AJ, Cohan P, Zehnder D, Adams JS. Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages. J Bone Miner Res. 2003 Mar; 18(3):579-82. view on PubMed
Adams JS, Chen H, Chun RF, Nguyen L, Wu S, Ren SY, Barsony J, Gacad MA. Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo. J Cell Biochem. 2003 Feb 01; 88(2):308-14. view on PubMed
Chen H, Hu B, Huang GH, Trainor AG, Abbott DH, Adams JS. Purification and characterization of a novel intracellular 17 beta-estradiol binding protein in estrogen-resistant New World primate cells. J Clin Endocrinol Metab. 2003 Jan; 88(1):501-4. view on PubMed
Hill JA, Goldin JG, Gjertson D, Emerick AM, Greaser LD, Yoon HC, Khorrami S, Aziz D, Adams JS. Progression of coronary artery calcification in patients taking alendronate for osteoporosis. Acad Radiol. 2002 Oct; 9(10):1148-52. view on PubMed
Wu S, Chun R, Gacad MA, Ren S, Chen H, Adams JS. Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1. Endocrinology. 2002 Oct; 143(10):4135. view on PubMed
Adams JY, Johnson M, Sato M, Berger F, Gambhir SS, Carey M, Iruela-Arispe ML, Wu L. Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging. Nat Med. 2002 Aug; 8(8):891-7. view on PubMed
Kantorovich V, Adams JS, Gaines JE, Guo X, Pandian MR, Cohn DH, Rude RK. Genetic heterogeneity in familial renal magnesium wasting. J Clin Endocrinol Metab. 2002 Feb; 87(2):612-7. view on PubMed
Chen H, Hu B, Allegretto EA, Adams JS. The vitamin D response element-binding protein. A novel dominant-negative regulator of vitamin D-directed transactivation. J Biol Chem. 2000 Nov 10; 275(45):35557-64. view on PubMed
Chen H, Hu B, Gacad MA, Adams JS. Cloning and expression of a novel dominant-negative-acting estrogen response element-binding protein in the heterogeneous nuclear ribonucleoprotein family. J Biol Chem. 1998 Nov 20; 273(47):31352-7. view on PubMed
Gacad MA, Chen H, Arbelle JE, LeBon T, Adams JS. Functional characterization and purification of an intracellular vitamin D-binding protein in vitamin D-resistant new world primate cells. Amino acid sequence homology with proteins in the hsp-70 family. J Biol Chem. 1997 Mar 28; 272(13):8433-40. view on PubMed
Adams JS, Ren SY. Autoregulation of 1,25-dihydroxyvitamin D synthesis in macrophage mitochondria by nitric oxide. Endocrinology. 1996 Oct; 137(10):4514-7. view on PubMed
Adams JS, Ren SY, Arbelle JE, Clemens TL, Shany S. A role for nitric oxide in the regulated expression of the 25-hydroxy-vitamin D-1-hydroxylation reaction in the chick myelomonocytic cell line HD-11. Endocrinology. 1994 Jan; 134(1):499-502. view on PubMed
Arbelle JE, Gacad MA, Spencer CA, Adams JS. Absence of thyroid hormone resistance in vitamin D-;resistant new world primates. Am J Primatol. 1994; 32(3):215-222. view on PubMed
Gacad MA, Deseran MW, Adams JS. Influence of ultraviolet B radiation on vitamin D3 metabolism in vitamin D3-resistant New World primates. Am J Primatol. 1992; 28(4):263-270. view on PubMed
Adams JS, Beeker TG, Hongo T, Clemens TL. Constitutive expression of a vitamin D 1-hydroxylase in a myelomonocytic cell line: a model for studying 1,25-dihydroxyvitamin D production in vitro. J Bone Miner Res. 1990 Dec; 5(12):1265-9. view on PubMed
Salusky IB, Goodman WG, Horst R, Segre GV, Kim L, Norris KC, Adams JS, Holloway M, Fine RN, Coburn JW. Pharmacokinetics of calcitriol in continuous ambulatory and cycling peritoneal dialysis patients. Am J Kidney Dis. 1990 Aug; 16(2):126-32. view on PubMed
Seeger LL, Butler DL, Eckardt JJ, Layfield L, Adams JS. Tumoral calcinosis-like lesion of the proximal linea aspera. Skeletal Radiol. 1990; 19(8):579-83. view on PubMed
Adams JS, Gacad MA, Rude RK, Deseran M, Endres DB, Mallette LE. Immunoreactive parathyroid hormone levels in platyrrhini and catarrhini: A comparative analysis with three different assays. Am J Primatol. 1987; 13(4):425-433. view on PubMed
Adams JS, Gacad MA, Baker AJ, Gonzales B, Rude RK. Serum concentrations of 1,25-dihydroxyvitamin D3 in Platyrrhini and Catarrhini: A phylogenetic appraisal. Am J Primatol. 1985; 9(3):219-224. view on PubMed
