Our ongoing research seeks to clarify the basis for disease resilience and vulnerability by discovering the feedback loops between neural excitability, neuroinflammation and cellular metabolic stress in neurodegeneration at cellular and circuit levels. Our unique approach uses a combination of transgenic mouse models, mathematical modeling, open and closed-loop electrophysiology, molecular imaging and cell cultures to address this challenge. Given the positive societal impact this research can have on human health and well-being, we passionately pursue this expedition against all odds!! Read more.

Some of our recent reports include (For a full list of our published work, click here):

Pre-synaptic and ambient GABA deficiencies in the SOD1G93A ALS mouse and more (Preprint) bioRXiv





Perturbed Cell Types and Pathways of Amyotrophic Lateral Sclerosis (2020) PMID: 32360664





Stretch Reflex Circuit and Sodium Channel Abnormalities in Amyotrophic Lateral Sclerosis (2019)  PMID: 31530644




Postnatal Deviance in Motor Neuron Excitability and Motor Pool Function in Amyotrophic Lateral Sclerosis (2015) PMID: 25589764