David Walker
Publications:
Schmid ET, Schinaman JM, Liu-Abramowicz N, Williams KS, Walker DW. Accumulation of F-actin drives brain aging and limits healthspan in Drosophila. Nat Commun. 2024 Oct 25; 15(1):9238. view on PubMed
Tran NT, Hale N, Maung AAW, Wiersma M, Walker DW, Polglase G, Castillo-Melendez M, Wong FY. Intrauterine inflammation and postnatal intravenous dopamine alter the neurovascular unit in preterm newborn lambs. J Neuroinflammation. 2024 May 28; 21(1):142. view on PubMed
Chincarini G, Walker DW, Wong F, Richardson SJ, Cumberland A, Tolcos M. Thyroid hormone analogues: Promising therapeutic avenues to improve the neurodevelopmental outcomes of intrauterine growth restriction. J Neurochem. 2024 Sep; 168(9):2335-2350. view on PubMed
Zhou Z, Ma A, Moore TM, Wolf DM, Yang N, Tran P, Segawa M, Strumwasser AR, Ren W, Fu K, Wanagat J, van der Bliek AM, Crosbie-Watson R, Liesa M, Stiles L, Acin-Perez R, Mahata S, Shirihai O, Goodarzi MO, Handzlik M, Metallo CM, Walker DW, Hevener AL. Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria. Sci Adv. 2024 Apr 05; 10(14):eadl0389. view on PubMed
Ahmadzadeh E, Dudink I, Walker DW, Sutherland AE, Pham Y, Stojanovska V, Polglase GR, Miller SL, Allison BJ. The medullary serotonergic centres involved in cardiorespiratory control are disrupted by fetal growth restriction. J Physiol. 2023 Aug 28. view on PubMed
Ahmadzadeh E, Polglase GR, Stojanovska V, Herlenius E, Walker DW, Miller SL, Allison BJ. Does fetal growth restriction induce neuropathology within the developing brainstem? J Physiol. 2023 11; 601(21):4667-4689. view on PubMed
Schmid ET, Schinaman JM, Williams KS, Walker DW. Accumulation of F-actin drives brain aging and limits healthspan in Drosophila. Res Sq. 2023 Aug 01. view on PubMed
Walker DW, Van Loon AF. Droughts are coming on faster. Science. 2023 Apr 14; 380(6641):130-132. view on PubMed
Choudhury M, Fu T, Amoah K, Jun HI, Chan TW, Park S, Walker DW, Bahn JH, Xiao X. Widespread RNA hypoediting in schizophrenia and its relevance to mitochondrial function. Sci Adv. 2023 04 07; 9(14):eade9997. view on PubMed
Salazar AM, Aparicio R, Clark RI, Rera M, Walker DW. Intestinal barrier dysfunction: an evolutionarily conserved hallmark of aging. Dis Model Mech. 2023 04 01; 16(4). view on PubMed
Tran NT, Muccini AM, Hale N, Tolcos M, Snow RJ, Walker DW, Ellery SJ. Creatine in the fetal brain: A regional investigation of acute global hypoxia and creatine supplementation in a translational fetal sheep model. Front Cell Neurosci. 2023; 17:1154772. view on PubMed
Miller SL, Bennet L, Sutherland AE, Pham Y, McDonald C, Castillo-Melendez M, Allison BJ, Mihelakis J, Nitsos I, Boyd BJ, Hirst JJ, Walker DW, Hunt RW, Jenkin G, Wong F, Malhotra A, Fahey MC, Yawno T. Ganaxolone versus Phenobarbital for Neonatal Seizure Management. Ann Neurol. 2022 12; 92(6):1066-1079. view on PubMed
Tran NT, Kowalski GM, Muccini AM, Nitsos I, Hale N, Snow RJ, Walker DW, Ellery SJ. Creatine supplementation reduces the cerebral oxidative and metabolic stress responses to acute in utero hypoxia in the late-gestation fetal sheep. J Physiol. 2022 07; 600(13):3193-3210. view on PubMed
Schmid ET, Pyo JH, Walker DW. Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in Drosophila. Nat Aging. 2022 06; 2(6):494-507. view on PubMed
Aparicio R, Schmid ET, Walker DW. Gut mitochondrial defects drive neurodegeneration. Nat Aging. 2022 04; 2(4):277-279. view on PubMed
Inocencio IM, Tran NT, Wiersma M, Stoecker K, Nakamura S, Moss TJ, Walker DW, Wong FY. The cerebral haemodynamic response to somatosensory stimulation in preterm newborn lambs is reduced following intrauterine inflammation and dopamine infusion. Exp Neurol. 2022 06; 352:114049. view on PubMed
Crombie GK, Palliser HK, Shaw JC, Hodgson DM, Walker DW, Hirst JJ. Evaluating changes in GABAergic and glutamatergic pathways in early life following prenatal stress and postnatal neurosteroid supplementation. Psychoneuroendocrinology. 2022 05; 139:105705. view on PubMed
Muccini AM, Tran NT, Hale N, McKenzie M, Snow RJ, Walker DW, Ellery SJ. The Effects of In Utero Fetal Hypoxia and Creatine Treatment on Mitochondrial Function in the Late Gestation Fetal Sheep Brain. Oxid Med Cell Longev. 2022; 2022:3255296. view on PubMed
Reses HE, Jones ES, Richardson DB, Cate KM, Walker DW, Shapiro CN. COVID-19 vaccination coverage among hospital-based healthcare personnel reported through the Department of Health and Human Services Unified Hospital Data Surveillance System, United States, January 20, 2021-September 15, 2021. Am J Infect Control. 2021 12; 49(12):1554-1557. view on PubMed
Belser M, Walker DW. Role of Prohibitins in Aging and Therapeutic Potential Against Age-Related Diseases. Front Genet. 2021; 12:714228. view on PubMed
Tran NT, Kelly SB, Snow RJ, Walker DW, Ellery SJ, Galinsky R. Assessing Creatine Supplementation for Neuroprotection against Perinatal Hypoxic-Ischaemic Encephalopathy: A Systematic Review of Perinatal and Adult Pre-Clinical Studies. Cells. 2021 10 27; 10(11). view on PubMed
Crombie GK, Palliser HK, Shaw JC, Hodgson DM, Walker DW, Hirst JJ. Neurosteroid-based intervention using Ganaxolone and Emapunil for improving stress-induced myelination deficits and neurobehavioural disorders. Psychoneuroendocrinology. 2021 11; 133:105423. view on PubMed
Inocencio IM, Tran NT, Nakamura S, Khor SJ, Wiersma M, Stoecker K, Maksimenko A, Polglase GR, Walker DW, Pearson JT, Wong FY. Cerebral haemodynamic response to somatosensory stimulation in preterm lambs and 7-10-day old lambs born at term: Direct synchrotron microangiography assessment. J Cereb Blood Flow Metab. 2022 02; 42(2):315-328. view on PubMed
Tran NT, Muccini AM, Snow RJ, Nitsos I, Hale N, Walker DW, Ellery SJ. The physiological effects of creatine supplementation in fetal sheep before, during, and after umbilical cord occlusion and global hypoxia. J Appl Physiol (1985). 2021 09 01; 131(3):1088-1099. view on PubMed
Xavier S, Gili J, McGowan P, Younesi S, Wright PFA, Walker DW, Spencer SJ, Sominsky L. Erratum: Xavier et al. High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming. Nutrients 2021, 13, 89. Nutrients. 2021 Jul 15; 13(7). view on PubMed
Hickmott RA, Bosakhar A, Quezada S, Barresi M, Walker DW, Ryan AL, Quigley A, Tolcos M. The One-Stop Gyrification Station - Challenges and New Technologies. Prog Neurobiol. 2021 09; 204:102111. view on PubMed
Baburamani AA, Tran NT, Castillo-Melendez M, Yawno T, Walker DW. Brief hypoxia in late gestation sheep causes prolonged disruption of fetal electrographic, breathing behaviours and can result in early labour. J Physiol. 2021 06; 599(12):3221-3236. view on PubMed
Cumberland AL, Hirst JJ, Badoer E, Wudy SA, Greaves RF, Zacharin M, Walker DW. The Enigma of the Adrenarche: Identifying the Early Life Mechanisms and Possible Role in Postnatal Brain Development. Int J Mol Sci. 2021 Apr 21; 22(9). view on PubMed
Inocencio IM, Tran NT, Khor SJ, Wiersma M, Nakamura S, Walker DW, Wong FY. The cerebral haemodynamic response to somatosensory stimulation in preterm newborn lambs is reduced with dopamine or dobutamine infusion. Exp Neurol. 2021 07; 341:113687. view on PubMed
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. Autophagy. 2021 Jan; 17(1):1-382. view on PubMed
Muccini AM, Tran NT, de Guingand DL, Philip M, Della Gatta PA, Galinsky R, Sherman LS, Kelleher MA, Palmer KR, Berry MJ, Walker DW, Snow RJ, Ellery SJ. Creatine Metabolism in Female Reproduction, Pregnancy and Newborn Health. Nutrients. 2021 Feb 02; 13(2). view on PubMed
Xavier S, Gili J, McGowan P, Younesi S, Wright PFA, Walker DW, Spencer SJ, Sominsky L. High Maternal Omega-3 Supplementation Dysregulates Body Weight and Leptin in Newborn Male and Female Rats: Implications for Hypothalamic Developmental Programming. Nutrients. 2020 Dec 30; 13(1). view on PubMed
Crombie GK, Palliser HK, Shaw JC, Hodgson DM, Walker DW, Hirst JJ. Effects of prenatal stress on behavioural and neurodevelopmental outcomes are altered by maternal separation in the neonatal period. Psychoneuroendocrinology. 2021 02; 124:105060. view on PubMed
Quezada S, van de Looij Y, Hale N, Rana S, Sizonenko SV, Gilchrist C, Castillo-Melendez M, Tolcos M, Walker DW. Genetic and microstructural differences in the cortical plate of gyri and sulci during gyrification in fetal sheep. Cereb Cortex. 2020 11 03; 30(12):6169-6190. view on PubMed
Ross-Munro E, Kwa F, Kreiner J, Khore M, Miller SL, Tolcos M, Fleiss B, Walker DW. Midkine: The Who, What, Where, and When of a Promising Neurotrophic Therapy for Perinatal Brain Injury. Front Neurol. 2020; 11:568814. view on PubMed
Wong FY, Gogos A, Hale N, Ingelse SA, Brew N, Shepherd KL, van den Buuse M, Walker DW. Impact of hypoxia-ischemia and dopamine treatment on dopamine receptor binding density in the preterm fetal sheep brain. J Appl Physiol (1985). 2020 12 01; 129(6):1431-1438. view on PubMed
Sominsky L, Walker DW, Spencer SJ. One size does not fit all - Patterns of vulnerability and resilience in the COVID-19 pandemic and why heterogeneity of disease matters. Brain Behav Immun. 2020 07; 87:1-3. view on PubMed
Aparicio R, Hansen M, Walker DW, Kumsta C. The selective autophagy receptor SQSTM1/p62 improves lifespan and proteostasis in an evolutionarily conserved manner. Autophagy. 2020 04; 16(4):772-774. view on PubMed
Ellery SJ, Murthi P, Gatta PAD, May AK, Davies-Tuck ML, Kowalski GM, Callahan DL, Bruce CR, Wallace EM, Walker DW, Dickinson H, Snow RJ. The Effects of Early-Onset Pre-Eclampsia on Placental Creatine Metabolism in the Third Trimester. Int J Mol Sci. 2020 Jan 26; 21(3). view on PubMed
Huggins DJ, Hardwick BS, Sharma P, Emery A, Laraia L, Zhang F, Narvaez AJ, Roberts-Thomson M, Crooks AT, Boyle RG, Boyce R, Walker DW, Mateu N, McKenzie GJ, Spring DR, Venkitaraman AR. Development of a Novel Cell-Permeable Protein-Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1. ACS Omega. 2020 Jan 14; 5(1):822-831. view on PubMed
Rana S, Shishegar R, Quezada S, Johnston L, Walker DW, Tolcos M. The Subplate: A Potential Driver of Cortical Folding? Cereb Cortex. 2019 12 17; 29(11):4697-4708. view on PubMed
Ellery SJ, Murthi P, Davies-Tuck ML, Della Gatta PA, May AK, Kowalski GM, Callahan DL, Bruce CR, Alers NO, Miller SL, Erwich JJHM, Wallace EM, Walker DW, Dickinson H, Snow RJ. Placental creatine metabolism in cases of placental insufficiency and reduced fetal growth. Mol Hum Reprod. 2019 08 01; 25(8):495-505. view on PubMed
Aparicio R, Rana A, Walker DW. Upregulation of the Autophagy Adaptor p62/SQSTM1 Prolongs Health and Lifespan in Middle-Aged Drosophila. Cell Rep. 2019 07 23; 28(4):1029-1040.e5. view on PubMed
Schinaman JM, Rana A, Ja WW, Clark RI, Walker DW. Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila. Sci Rep. 2019 05 24; 9(1):7824. view on PubMed
Ranzil S, Ellery S, Walker DW, Vaillancourt C, Alfaidy N, Bonnin A, Borg A, Wallace EM, Ebeling PR, Erwich JJ, Murthi P. Disrupted placental serotonin synthetic pathway and increased placental serotonin: Potential implications in the pathogenesis of human fetal growth restriction. Placenta. 2019 09 01; 84:74-83. view on PubMed
Fleiss B, Wong F, Brownfoot F, Shearer IK, Baud O, Walker DW, Gressens P, Tolcos M. Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury. Front Endocrinol (Lausanne). 2019; 10:188. view on PubMed
Berry MJ, Schlegel M, Kowalski GM, Bruce CR, Callahan DL, Davies-Tuck ML, Dickinson H, Goodson A, Slocombe A, Snow RJ, Walker DW, Ellery SJ. UNICORN Babies: Understanding Circulating and Cerebral Creatine Levels of the Preterm Infant. An Observational Study Protocol. Front Physiol. 2019; 10:142. view on PubMed
Nguyen NN, Rana A, Goldman C, Moore R, Tai J, Hong Y, Shen J, Walker DW, Hur JH. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster. Sci Rep. 2019 02 28; 9(1):3170. view on PubMed
Ellery SJ, Goss MG, Brew N, Dickinson H, Hale N, LaRosa DA, Walker DW, Wong FY. Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse. Neurotherapeutics. 2019 01; 16(1):231-243. view on PubMed
Ranzil S, Walker DW, Borg AJ, Wallace EM, Ebeling PR, Murthi P. The relationship between the placental serotonin pathway and fetal growth restriction. Biochimie. 2019 Jun; 161:80-87. view on PubMed
Greaves RF, Wudy SA, Badoer E, Zacharin M, Hirst JJ, Quinn T, Walker DW. A tale of two steroids: The importance of the androgens DHEA and DHEAS for early neurodevelopment. J Steroid Biochem Mol Biol. 2019 04; 188:77-85. view on PubMed
Hirst JJ, Palliser HK, Shaw JC, Crombie G, Walker DW, Zakar T. Birth and Neonatal Transition in the Guinea Pig: Experimental Approaches to Prevent Preterm Birth and Protect the Premature Fetus. Front Physiol. 2018; 9:1802. view on PubMed
Quezada S, Castillo-Melendez M, Walker DW, Tolcos M. Development of the cerebral cortex and the effect of the intrauterine environment. J Physiol. 2018 12; 596(23):5665-5674. view on PubMed
Salazar AM, Resnik-Docampo M, Ulgherait M, Clark RI, Shirasu-Hiza M, Jones DL, Walker DW. Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity. iScience. 2018 Nov 30; 9:229-243. view on PubMed
Hansen M, Rubinsztein DC, Walker DW. Autophagy as a promoter of longevity: insights from model organisms. Nat Rev Mol Cell Biol. 2018 09; 19(9):579-593. view on PubMed
Hansen M, Rubinsztein DC, Walker DW. Publisher Correction: Autophagy as a promoter of longevity: insights from model organisms. Nat Rev Mol Cell Biol. 2018 Sep; 19(9):611. view on PubMed
Hutchinson DS, Brew N, Vu T, Merlin J, Hale N, Walker DW, Wong FY. Effects of hypoxia-ischemia and inotropes on expression of cardiac adrenoceptors in the preterm fetal sheep. J Appl Physiol (1985). 2018 11 01; 125(5):1368-1377. view on PubMed
Ellery SJ, Kelleher M, Grigsby P, Burd I, Derks JB, Hirst J, Miller SL, Sherman LS, Tolcos M, Walker DW. Antenatal prevention of cerebral palsy and childhood disability: is the impossible possible? J Physiol. 2018 12; 596(23):5593-5609. view on PubMed
Brew N, Nakamura S, Hale N, Azhan A, Davies GI, Nitsos I, Miller SL, Walker DW, Wong FY. Dobutamine treatment reduces inflammation in the preterm fetal sheep brain exposed to acute hypoxia. Pediatr Res. 2018 09; 84(3):442-450. view on PubMed
Bennet L, Walker DW, Horne RSC. Waking up too early - the consequences of preterm birth on sleep development. J Physiol. 2018 12; 596(23):5687-5708. view on PubMed
Resnik-Docampo M, Sauer V, Schinaman JM, Clark RI, Walker DW, Jones DL. Keeping it tight: The relationship between bacterial dysbiosis, septate junctions, and the intestinal barrier in Drosophila. Fly (Austin). 2018 01 02; 12(1):34-40. view on PubMed
Clark RI, Walker DW. Role of gut microbiota in aging-related health decline: insights from invertebrate models. Cell Mol Life Sci. 2018 01; 75(1):93-101. view on PubMed
Bennett GA, Palliser HK, Shaw JC, Palazzi KL, Walker DW, Hirst JJ. Maternal stress in pregnancy affects myelination and neurosteroid regulatory pathways in the guinea pig cerebellum. Stress. 2017 11; 20(6):580-588. view on PubMed
Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW. Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster. Nat Commun. 2017 09 06; 8(1):448. view on PubMed
Yawno T, Miller SL, Bennet L, Wong F, Hirst JJ, Fahey M, Walker DW. Ganaxolone: A New Treatment for Neonatal Seizures. Front Cell Neurosci. 2017; 11:246. view on PubMed
Mamrot J, Legaie R, Ellery SJ, Wilson T, Seemann T, Powell DR, Gardner DK, Walker DW, Temple-Smith P, Papenfuss AT, Dickinson H. De novo transcriptome assembly for the spiny mouse (Acomys cahirinus). Sci Rep. 2017 08 21; 7(1):8996. view on PubMed
Narvaez AJ, Ber S, Crooks A, Emery A, Hardwick B, Guarino Almeida E, Huggins DJ, Perera D, Roberts-Thomson M, Azzarelli R, Hood FE, Prior IA, Walker DW, Boyce R, Boyle RG, Barker SP, Torrance CJ, McKenzie GJ, Venkitaraman AR. Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS. Cell Chem Biol. 2017 Aug 17; 24(8):1017-1028.e7. view on PubMed
Nakamura S, Walker DW, Wong FY. Cerebral haemodynamic response to somatosensory stimulation in neonatal lambs. J Physiol. 2017 09 01; 595(17):6007-6021. view on PubMed
Dickinson H, Ellery S, Davies-Tuck M, Tolcos M, Nitsos I, Walker DW, Miller SL. Description of a method for inducing fetal growth restriction in the spiny mouse. J Dev Orig Health Dis. 2017 Oct; 8(5):550-555. view on PubMed
Cumberland AL, Palliser HK, Rani P, Walker DW, Hirst JJ. Effects of combined IUGR and prenatal stress on the development of the hippocampus in a fetal guinea pig model. J Dev Orig Health Dis. 2017 Oct; 8(5):584-596. view on PubMed
Tolcos M, Petratos S, Hirst JJ, Wong F, Spencer SJ, Azhan A, Emery B, Walker DW. Blocked, delayed, or obstructed: What causes poor white matter development in intrauterine growth restricted infants? Prog Neurobiol. 2017 Jul; 154:62-77. view on PubMed
Cumberland AL, Palliser HK, Walker DW, Hirst JJ. Cerebellar Changes in Guinea Pig Offspring Following Suppression of Neurosteroid Synthesis During Late Gestation. Cerebellum. 2017 04; 16(2):306-313. view on PubMed
Ellery SJ, Della Gatta PA, Bruce CR, Kowalski GM, Davies-Tuck M, Mockler JC, Murthi P, Walker DW, Snow RJ, Dickinson H. Creatine biosynthesis and transport by the term human placenta. Placenta. 2017 04; 52:86-93. view on PubMed
LaRosa DA, Ellery SJ, Walker DW, Dickinson H. Understanding the Full Spectrum of Organ Injury Following Intrapartum Asphyxia. Front Pediatr. 2017; 5:16. view on PubMed
Murthi P, Wallace EM, Walker DW. Altered placental tryptophan metabolic pathway in human fetal growth restriction. Placenta. 2017 04; 52:62-70. view on PubMed
Cumberland AL, Palliser HK, Crombie GK, Walker DW, Hirst JJ. Increased anxiety-like phenotype in female guinea pigs following reduced neurosteroid exposure in utero. Int J Dev Neurosci. 2017 May; 58:50-58. view on PubMed
Ellery SJ, LaRosa DA, Cullen-McEwen LA, Brown RD, Snow RJ, Walker DW, Kett MM, Dickinson H. Renal dysfunction in early adulthood following birth asphyxia in male spiny mice, and its amelioration by maternal creatine supplementation during pregnancy. Pediatr Res. 2017 Apr; 81(4):646-653. view on PubMed
Resnik-Docampo M, Koehler CL, Clark RI, Schinaman JM, Sauer V, Wong DM, Lewis S, D'Alterio C, Walker DW, Jones DL. Tricellular junctions regulate intestinal stem cell behaviour to maintain homeostasis. Nat Cell Biol. 2017 Jan; 19(1):52-59. view on PubMed
Nakamura S, Walker DW, Wong FY. Cerebral haemodynamic response to somatosensory stimulation in near-term fetal sheep. J Physiol. 2017 02 15; 595(4):1289-1303. view on PubMed
Dickinson H, Davies-Tuck M, Ellery SJ, Grieger JA, Wallace EM, Snow RJ, Walker DW, Clifton VL. Maternal creatine in pregnancy: a retrospective cohort study. BJOG. 2016 Oct; 123(11):1830-8. view on PubMed
Bellofiore N, Ellery SJ, Mamrot J, Walker DW, Temple-Smith P, Dickinson H. First evidence of a menstruating rodent: the spiny mouse (Acomys cahirinus). Am J Obstet Gynecol. 2017 Jan; 216(1):40.e1-40.e11. view on PubMed
Shishegar R, Tolcos M, Walker DW, Johnston LA. Sulcal curve extraction using Laplace Beltrami eigenfunction level sets. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:4043-4046. view on PubMed
LaRosa DA, Ellery SJ, Snow RJ, Walker DW, Dickinson H. Maternal creatine supplementation during pregnancy prevents acute and long-term deficits in skeletal muscle after birth asphyxia: a study of structure and function of hind limb muscle in the spiny mouse. Pediatr Res. 2016 12; 80(6):852-860. view on PubMed
LaRosa DA, Ellery SJ, Parkington HC, Snow RJ, Walker DW, Dickinson H. Maternal Creatine Supplementation during Pregnancy Prevents Long-Term Changes in Diaphragm Muscle Structure and Function after Birth Asphyxia. PLoS One. 2016; 11(3):e0149840. view on PubMed
Ellery SJ, Walker DW, Dickinson H. Creatine for women: a review of the relationship between creatine and the reproductive cycle and female-specific benefits of creatine therapy. Amino Acids. 2016 08; 48(8):1807-17. view on PubMed
Murthi P, Yong HE, Ngyuen TP, Ellery S, Singh H, Rahman R, Dickinson H, Walker DW, Davies-Tuck M, Wallace EM, Ebeling PR. Role of the Placental Vitamin D Receptor in Modulating Feto-Placental Growth in Fetal Growth Restriction and Preeclampsia-Affected Pregnancies. Front Physiol. 2016; 7:43. view on PubMed
Bhattacharya A, Mamcarz M, Mullins C, Choudhury A, Boyle RG, Smith DG, Walker DW, Klann E. Targeting Translation Control with p70 S6 Kinase 1 Inhibitors to Reverse Phenotypes in Fragile X Syndrome Mice. Neuropsychopharmacology. 2016 07; 41(8):1991-2000. view on PubMed
Ellery SJ, LaRosa DA, Kett MM, Della Gatta PA, Snow RJ, Walker DW, Dickinson H. Dietary creatine supplementation during pregnancy: a study on the effects of creatine supplementation on creatine homeostasis and renal excretory function in spiny mice. Amino Acids. 2016 08; 48(8):1819-30. view on PubMed
Brew N, Azhan A, den Heijer I, Boomgardt M, Davies GI, Nitsos I, Miller SL, Walker AM, Walker DW, Wong FY. Dopamine treatment during acute hypoxia is neuroprotective in the developing sheep brain. Neuroscience. 2016 Mar 01; 316:82-93. view on PubMed
Ellery SJ, Dickinson H, McKenzie M, Walker DW. Dietary interventions designed to protect the perinatal brain from hypoxic-ischemic encephalopathy--Creatine prophylaxis and the need for multi-organ protection. Neurochem Int. 2016 May; 95:15-23. view on PubMed
Quinn TA, Ratnayake U, Dickinson H, Castillo-Melendez M, Walker DW. Ontogenetic Change in the Regional Distribution of Dehydroepiandrosterone-Synthesizing Enzyme and the Glucocorticoid Receptor in the Brain of the Spiny Mouse (Acomys cahirinus). Dev Neurosci. 2016; 38(1):54-73. view on PubMed
Quinn TA, Ratnayake U, Dickinson H, Castillo-Melendez M, Walker DW. The feto-placental unit, and potential roles of dehydroepiandrosterone (DHEA) in prenatal and postnatal brain development: A re-examination using the spiny mouse. J Steroid Biochem Mol Biol. 2016 Jun; 160:204-13. view on PubMed
Hirst JJ, Cumberland AL, Shaw JC, Bennett GA, Kelleher MA, Walker DW, Palliser HK. Loss of neurosteroid-mediated protection following stress during fetal life. J Steroid Biochem Mol Biol. 2016 06; 160:181-8. view on PubMed
Clark RI, Salazar A, Yamada R, Fitz-Gibbon S, Morselli M, Alcaraz J, Rana A, Rera M, Pellegrini M, Ja WW, Walker DW. Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality. Cell Rep. 2015 Sep 08; 12(10):1656-67. view on PubMed
Icreverzi A, de la Cruz AF, Walker DW, Edgar BA. Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. Aging Cell. 2015 Oct; 14(5):896-906. view on PubMed
Yan EB, Frugier T, Lim CK, Heng B, Sundaram G, Tan M, Rosenfeld JV, Walker DW, Guillemin GJ, Morganti-Kossmann MC. Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans. J Neuroinflammation. 2015 May 30; 12:110. view on PubMed
Palliser HK, Kelleher MA, Tolcos M, Walker DW, Hirst JJ. Effect of postnatal progesterone therapy following preterm birth on neurosteroid concentrations and cerebellar myelination in guinea pigs. J Dev Orig Health Dis. 2015 Aug; 6(4):350-61. view on PubMed
Ellery SJ, LaRosa DA, Kett MM, Della Gatta PA, Snow RJ, Walker DW, Dickinson H. Maternal creatine homeostasis is altered during gestation in the spiny mouse: is this a metabolic adaptation to pregnancy? BMC Pregnancy Childbirth. 2015 Apr 14; 15:92. view on PubMed
Shaw JC, Palliser HK, Walker DW, Hirst JJ. Preterm birth affects GABAA receptor subunit mRNA levels during the foetal-to-neonatal transition in guinea pigs. J Dev Orig Health Dis. 2015 Jun; 6(3):250-60. view on PubMed
Dickinson H, Bain E, Wilkinson D, Middleton P, Crowther CA, Walker DW. Creatine for women in pregnancy for neuroprotection of the fetus. Cochrane Database Syst Rev. 2014 Dec 19; (12):CD010846. view on PubMed
Hutton LC, Yan E, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW. Injury of the developing cerebellum: a brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus. Cerebellum. 2014 Dec; 13(6):777-86. view on PubMed
Ulgherait M, Rana A, Rera M, Graniel J, Walker DW. AMPK modulates tissue and organismal aging in a non-cell-autonomous manner. Cell Rep. 2014 Sep 25; 8(6):1767-1780. view on PubMed
Ratnayake U, Quinn T, Daruwalla K, Dickinson H, Walker DW. Understanding the behavioural phenotype of the precocial spiny mouse. Behav Brain Res. 2014 Dec 15; 275:62-71. view on PubMed
Hur JH, Stork DA, Walker DW. Complex-I-ty in aging. J Bioenerg Biomembr. 2014 Aug; 46(4):329-35. view on PubMed
Yawno T, Mortale M, Sutherland AE, Jenkin G, Wallace EM, Walker DW, Miller SL. The effects of betamethasone on allopregnanolone concentrations and brain development in preterm fetal sheep. Neuropharmacology. 2014 Oct; 85:342-8. view on PubMed
Ratnayake U, Quinn T, LaRosa DA, Dickinson H, Walker DW. Prenatal exposure to the viral mimetic poly I:C alters fetal brain cytokine expression and postnatal behaviour. Dev Neurosci. 2014; 36(2):83-94. view on PubMed
Quinn TA, Ratnayake U, Castillo-Melendez M, Moritz KM, Dickinson H, Walker DW. Adrenal steroidogenesis following prenatal dexamethasone exposure in the spiny mouse. J Endocrinol. 2014 May; 221(2):347-62. view on PubMed
Dickinson H, Ellery S, Ireland Z, LaRosa D, Snow R, Walker DW. Creatine supplementation during pregnancy: summary of experimental studies suggesting a treatment to improve fetal and neonatal morbidity and reduce mortality in high-risk human pregnancy. BMC Pregnancy Childbirth. 2014 Apr 27; 14:150. view on PubMed
Parkington HC, Kenna KR, Sozo F, Coleman HA, Bocking A, Brien JF, Harding R, Walker DW, Morley R, Tare M. Maternal alcohol consumption in pregnancy enhances arterial stiffness and alters vasodilator function that varies between vascular beds in fetal sheep. J Physiol. 2014 Jun 15; 592(12):2591-603. view on PubMed
Miller SL, Yawno T, Alers NO, Castillo-Melendez M, Supramaniam VG, VanZyl N, Sabaretnam T, Loose JM, Drummond GR, Walker DW, Jenkin G, Wallace EM. Antenatal antioxidant treatment with melatonin to decrease newborn neurodevelopmental deficits and brain injury caused by fetal growth restriction. J Pineal Res. 2014 Apr; 56(3):283-94. view on PubMed
Miller SL, Walker DW. The challenge of protecting the perinatal brain against hypoxic ischaemic injury - hasten slowly. J Physiol. 2014 Feb 01; 592(3):425-6. view on PubMed
Clark RI, Walker DW, Dionne MS. Metabolic and immune integration in aging and age-related disease. Aging (Albany NY). 2014 Jan; 6(1):3-4. view on PubMed
Castillo-Melendez M, Baburamani AA, Cabalag C, Yawno T, Witjaksono A, Miller SL, Walker DW. Experimental modelling of the consequences of brief late gestation asphyxia on newborn lamb behaviour and brain structure. PLoS One. 2013; 8(11):e77377. view on PubMed
Ratnayake U, Quinn T, Walker DW, Dickinson H. Cytokines and the neurodevelopmental basis of mental illness. Front Neurosci. 2013 Oct 17; 7:180. view on PubMed
Clark RI, Tan SW, Péan CB, Roostalu U, Vivancos V, Bronda K, Pilátová M, Fu J, Walker DW, Berdeaux R, Geissmann F, Dionne MS. MEF2 is an in vivo immune-metabolic switch. Cell. 2013 Oct 10; 155(2):435-47. view on PubMed
Bennett GA, Palliser HK, Saxby B, Walker DW, Hirst JJ. Effects of prenatal stress on fetal neurodevelopment and responses to maternal neurosteroid treatment in Guinea pigs. Dev Neurosci. 2013; 35(5):416-26. view on PubMed
Hur JH, Bahadorani S, Graniel J, Koehler CL, Ulgherait M, Rera M, Jones DL, Walker DW. Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells. Aging (Albany NY). 2013 Sep; 5(9):662-81. view on PubMed
Rera M, Clark RI, Walker DW. Why do old flies die? Aging (Albany NY). 2013 Aug; 5(8):586-7. view on PubMed
O'Connell BA, Moritz KM, Walker DW, Dickinson H. Treatment of pregnant spiny mice at mid gestation with a synthetic glucocorticoid has sex-dependent effects on placental glycogen stores. Placenta. 2013 Oct; 34(10):932-40. view on PubMed
Hirst JJ, Kelleher MA, Walker DW, Palliser HK. Neuroactive steroids in pregnancy: key regulatory and protective roles in the foetal brain. J Steroid Biochem Mol Biol. 2014 Jan; 139:144-53. view on PubMed
Rana A, Rera M, Walker DW. Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):8638-43. view on PubMed
Dickinson H, Ireland ZJ, Larosa DA, O'Connell BA, Ellery S, Snow R, Walker DW. Maternal dietary creatine supplementation does not alter the capacity for creatine synthesis in the newborn spiny mouse. Reprod Sci. 2013 Sep; 20(9):1096-102. view on PubMed
Yawno T, Castillo-Melendez M, Jenkin G, Wallace EM, Walker DW, Miller SL. Mechanisms of melatonin-induced protection in the brain of late gestation fetal sheep in response to hypoxia. Dev Neurosci. 2012; 34(6):543-51. view on PubMed
O'Connell BA, Moritz KM, Walker DW, Dickinson H. Synthetic glucocorticoid dexamethasone inhibits branching morphogenesis in the spiny mouse placenta. Biol Reprod. 2013 Jan; 88(1):26. view on PubMed
Quinn TA, Ratnayake U, Dickinson H, Nguyen TH, McIntosh M, Castillo-Melendez M, Conley AJ, Walker DW. Ontogeny of the adrenal gland in the spiny mouse, with particular reference to production of the steroids cortisol and dehydroepiandrosterone. Endocrinology. 2013 Mar; 154(3):1190-201. view on PubMed
O'Connell BA, Moritz KM, Walker DW, Dickinson H. Sexually dimorphic placental development throughout gestation in the spiny mouse (Acomys cahirinus). Placenta. 2013 Feb; 34(2):119-26. view on PubMed
Rera M, Clark RI, Walker DW. Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci U S A. 2012 Dec 26; 109(52):21528-33. view on PubMed
Baburamani AA, Castillo-Melendez M, Walker DW. VEGF expression and microvascular responses to severe transient hypoxia in the fetal sheep brain. Pediatr Res. 2013 Mar; 73(3):310-6. view on PubMed
Cho J, Hur JH, Graniel J, Benzer S, Walker DW. Expression of yeast NDI1 rescues a Drosophila complex I assembly defect. PLoS One. 2012; 7(11):e50644. view on PubMed
Ellery SJ, Ireland Z, Kett MM, Snow R, Walker DW, Dickinson H. Creatine pretreatment prevents birth asphyxia-induced injury of the newborn spiny mouse kidney. Pediatr Res. 2013 Feb; 73(2):201-8. view on PubMed
Baburamani AA, Ek CJ, Walker DW, Castillo-Melendez M. Vulnerability of the developing brain to hypoxic-ischemic damage: contribution of the cerebral vasculature to injury and repair? Front Physiol. 2012; 3:424. view on PubMed
Baburamani AA, Lo C, Castillo-Melendez M, Walker DW. Morphological evaluation of the cerebral blood vessels in the late gestation fetal sheep following hypoxia in utero. Microvasc Res. 2013 Jan; 85:1-9. view on PubMed
Ratnayake U, Quinn TA, Castillo-Melendez M, Dickinson H, Walker DW. Behaviour and hippocampus-specific changes in spiny mouse neonates after treatment of the mother with the viral-mimetic Poly I:C at mid-pregnancy. Brain Behav Immun. 2012 Nov; 26(8):1288-99. view on PubMed
Kenna K, Sozo F, De Matteo R, Hanita T, Gray SP, Tare M, Moritz K, Bertram JF, Black MJ, Brien JF, Parkington HC, Walker DW, Harding R. Alcohol exposure during late gestation: multiple developmental outcomes in sheep. J Dev Orig Health Dis. 2012 Aug; 3(4):224-36. view on PubMed
Rolka H, Walker DW, English R, Katzoff MJ, Scogin G, Neuhaus E, Centers for Disease Control and Prevention. Analytical challenges for emerging public health surveillance. MMWR Suppl. 2012 Jul 27; 61(3):35-40. view on PubMed
Rera M, Azizi MJ, Walker DW. Organ-specific mediation of lifespan extension: more than a gut feeling? Ageing Res Rev. 2013 Jan; 12(1):436-44. view on PubMed
Miller SL, Wallace EM, Walker DW. Antioxidant therapies: a potential role in perinatal medicine. Neuroendocrinology. 2012; 96(1):13-23. view on PubMed
Pasco R, Gardner DK, Walker DW, Dickinson H. A superovulation protocol for the spiny mouse (Acomys cahirinus). Reprod Fertil Dev. 2012; 24(8):1117-22. view on PubMed
Miller SL, Sutherland AE, Supramaniam VG, Walker DW, Jenkin G, Wallace EM. Antenatal glucocorticoids reduce growth in appropriately grown and growth-restricted ovine fetuses in a sex-specific manner. Reprod Fertil Dev. 2012; 24(5):753-8. view on PubMed
Cannata DJ, Crossley KJ, Barclay CJ, Walker DW, West JM. Contribution of stretch to the change of activation properties of muscle fibers in the diaphragm at the transition from fetal to neonatal life. Front Physiol. 2011; 2:109. view on PubMed
Chen HK, Liu Z, Meyer-Franke A, Brodbeck J, Miranda RD, McGuire JG, Pleiss MA, Ji ZS, Balestra ME, Walker DW, Xu Q, Jeong DE, Budamagunta MS, Voss JC, Freedman SB, Weisgraber KH, Huang Y, Mahley RW. Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons. J Biol Chem. 2012 Feb 17; 287(8):5253-66. view on PubMed
Fleiss B, Parkington HC, Coleman HA, Dickinson H, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW. Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse. Brain Res. 2012 Jan 18; 1433:9-19. view on PubMed
Rera M, Bahadorani S, Cho J, Koehler CL, Ulgherait M, Hur JH, Ansari WS, Lo T, Jones DL, Walker DW. Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog. Cell Metab. 2011 Nov 02; 14(5):623-34. view on PubMed
Walker DW, Atkinson MP, Brooke JM, Watson P. Selected papers from the 2010 e-Science All Hands Meeting. Philos Trans A Math Phys Eng Sci. 2011 Aug 28; 369(1949):3251-3. view on PubMed
O'Connell BA, Moritz KM, Roberts CT, Walker DW, Dickinson H. The placental response to excess maternal glucocorticoid exposure differs between the male and female conceptus in spiny mice. Biol Reprod. 2011 Nov; 85(5):1040-7. view on PubMed
Ireland Z, Castillo-Melendez M, Dickinson H, Snow R, Walker DW. A maternal diet supplemented with creatine from mid-pregnancy protects the newborn spiny mouse brain from birth hypoxia. Neuroscience. 2011 Oct 27; 194:372-9. view on PubMed
Fleiss B, Coleman HA, Castillo-Melendez M, Ireland Z, Walker DW, Parkington HC. Effects of birth asphyxia on neonatal hippocampal structure and function in the spiny mouse. Int J Dev Neurosci. 2011 Nov; 29(7):757-66. view on PubMed
Kelleher MA, Palliser HK, Walker DW, Hirst JJ. Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development. J Endocrinol. 2011 Mar; 208(3):301-9. view on PubMed
Cannata DJ, Ireland Z, Dickinson H, Snow RJ, Russell AP, West JM, Walker DW. Maternal creatine supplementation from mid-pregnancy protects the diaphragm of the newborn spiny mouse from intrapartum hypoxia-induced damage. Pediatr Res. 2010 Nov; 68(5):393-8. view on PubMed
Dharane Neé Ligam P, Manuelpillai U, Wallace E, Walker DW. NFκB-dependent increase of kynurenine pathway activity in human placenta: inhibition by sulfasalazine. Placenta. 2010 Nov; 31(11):997-1002. view on PubMed
Yawno T, Yan EB, Hirst JJ, Walker DW. Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states. Stress. 2011 Jan; 14(1):13-22. view on PubMed
Cho J, Hur JH, Walker DW. The role of mitochondria in Drosophila aging. Exp Gerontol. 2011 May; 46(5):331-4. view on PubMed
Bahadorani S, Cho J, Lo T, Contreras H, Lawal HO, Krantz DE, Bradley TJ, Walker DW. Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan. Aging Cell. 2010 Apr; 9(2):191-202. view on PubMed
Hur JH, Cho J, Walker DW. Aging: Dial M for Mitochondria. Aging (Albany NY). 2010 Jan 26; 2(1):69-73. view on PubMed
Muffat J, Walker DW. Apolipoprotein D: an overview of its role in aging and age-related diseases. Cell Cycle. 2010 Jan 15; 9(2):269-73. view on PubMed
Bahadorani S, Bahadorani P, Marcon E, Walker DW, Hilliker AJ. A Drosophila model of Menkes disease reveals a role for DmATP7 in copper absorption and neurodevelopment. Dis Model Mech. 2010 Jan-Feb; 3(1-2):84-91. view on PubMed
McKendry AA, Palliser HK, Yates DM, Walker DW, Hirst JJ. The effect of betamethasone treatment on neuroactive steroid synthesis in a foetal Guinea pig model of growth restriction. J Neuroendocrinol. 2010 Mar; 22(3):166-74. view on PubMed
Bahadorani S, Hur JH, Lo T, Vu K, Walker DW. Perturbation of mitochondrial complex V alters the response to dietary restriction in Drosophila. Aging Cell. 2010 Feb; 9(1):100-3. view on PubMed
Hur JH, Walker DW. p53, sex, and aging: lessons from the fruit fly. Aging (Albany NY). 2009 Nov 13; 1(11):881-3. view on PubMed
Hutton LC, Ratnayake U, Shields A, Walker DW. Neuropathology and functional deficits in a model of birth asphyxia in the precocial spiny mouse (Acomys cahirinus). Dev Neurosci. 2009; 31(6):523-35. view on PubMed
Miller SL, Supramaniam VG, Jenkin G, Walker DW, Wallace EM. Cardiovascular responses to maternal betamethasone administration in the intrauterine growth-restricted ovine fetus. Am J Obstet Gynecol. 2009 Dec; 201(6):613.e1-8. view on PubMed
Copeland JM, Cho J, Lo T, Hur JH, Bahadorani S, Arabyan T, Rabie J, Soh J, Walker DW. Extension of Drosophila life span by RNAi of the mitochondrial respiratory chain. Curr Biol. 2009 Oct 13; 19(19):1591-8. view on PubMed
Hirst JJ, Walker DW, Yawno T, Palliser HK. Stress in pregnancy: a role for neuroactive steroids in protecting the fetal and neonatal brain. Dev Neurosci. 2009; 31(5):363-77. view on PubMed
Hutton LC, Abbass M, Dickinson H, Ireland Z, Walker DW. Neuroprotective properties of melatonin in a model of birth asphyxia in the spiny mouse (Acomys cahirinus). Dev Neurosci. 2009; 31(5):437-51. view on PubMed
Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW. Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. Neuroscience. 2009 Oct 20; 163(3):838-47. view on PubMed
Ireland Z, Dickinson H, Fleiss B, Hutton LC, Walker DW. Behavioural effects of near-term acute fetal hypoxia in a small precocial animal, the spiny mouse (Acomys cahirinus). Neonatology. 2010; 97(1):45-51. view on PubMed
Ireland Z, Russell AP, Wallimann T, Walker DW, Snow R. Developmental changes in the expression of creatine synthesizing enzymes and creatine transporter in a precocial rodent, the spiny mouse. BMC Dev Biol. 2009 Jul 01; 9:39. view on PubMed
Downes P, Yaikhom G, Giddy JP, Walker DW, Spezi E, Lewis DG. High-performance computing for Monte Carlo radiotherapy calculations. Philos Trans A Math Phys Eng Sci. 2009 Jun 28; 367(1897):2607-17. view on PubMed
Yan EB, Baburamani AA, Walker AM, Walker DW. Changes in cerebral blood flow, cerebral metabolites, and breathing movements in the sheep fetus following asphyxia produced by occlusion of the umbilical cord. Am J Physiol Regul Integr Comp Physiol. 2009 Jul; 297(1):R60-9. view on PubMed
Hull-Thompson J, Muffat J, Sanchez D, Walker DW, Benzer S, Ganfornina MD, Jasper H. Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet. 2009 Apr; 5(4):e1000460. view on PubMed
Geng G, Johnston LA, Yan E, Britto JM, Smith DW, Walker DW, Egan GF. Biomechanisms for modelling cerebral cortical folding. Med Image Anal. 2009 Dec; 13(6):920-30. view on PubMed
Dickinson H, Griffiths T, Walker DW, Jenkin G. Application of clinical indices of fetal growth and wellbeing to a novel laboratory species, the spiny mouse. Reprod Biol. 2008 Nov; 8(3):229-43. view on PubMed
Gray SP, Kenna K, Bertram JF, Hoy WE, Yan EB, Bocking AD, Brien JF, Walker DW, Harding R, Moritz KM. Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2008 Aug; 295(2):R568-74. view on PubMed
Westcott KT, Hirst JJ, Ciurej I, Walker DW, Wlodek ME. Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency. Neuroendocrinology. 2008; 88(4):287-92. view on PubMed
Muffat J, Walker DW, Benzer S. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):7088-93. view on PubMed
Dickinson H, Walker DW, Castillo-Melendez M. Onset of feeding at birth--perinatal development of the hypothalamic mechanisms that induce appetite and feeding in the newborn. Neurosci Lett. 2008 May 02; 436(1):1-6. view on PubMed
Ireland Z, Dickinson H, Snow R, Walker DW. Maternal creatine: does it reach the fetus and improve survival after an acute hypoxic episode in the spiny mouse (Acomys cahirinus)? Am J Obstet Gynecol. 2008 Apr; 198(4):431.e1-6. view on PubMed
Hutton LC, Castillo-Melendez M, Smythe GA, Walker DW. Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation. Am J Obstet Gynecol. 2008 Jan; 198(1):117.e1-11. view on PubMed
Hirst JJ, Palliser HK, Yates DM, Yawno T, Walker DW. Neurosteroids in the fetus and neonate: potential protective role in compromised pregnancies. Neurochem Int. 2008 Mar-Apr; 52(4-5):602-10. view on PubMed
Dickinson H, Moritz K, Wintour EM, Walker DW, Kett MM. A comparative study of renal function in the desert-adapted spiny mouse and the laboratory-adapted C57BL/6 mouse: response to dietary salt load. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1093-8. view on PubMed
Yawno T, Yan EB, Walker DW, Hirst JJ. Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep. Neuroscience. 2007 Jun 08; 146(4):1726-33. view on PubMed
Hutton LC, Castillo-Melendez M, Walker DW. Uteroplacental inflammation results in blood brain barrier breakdown, increased activated caspase 3 and lipid peroxidation in the late gestation ovine fetal cerebellum. Dev Neurosci. 2007; 29(4-5):341-54. view on PubMed
Hirst JJ, Yawno T, Nguyen P, Walker DW. Stress in pregnancy activates neurosteroid production in the fetal brain. Neuroendocrinology. 2006; 84(4):264-74. view on PubMed
Miller SL, Chai M, Loose J, Castillo-Meléndez M, Walker DW, Jenkin G, Wallace EM. The effects of maternal betamethasone administration on the intrauterine growth-restricted fetus. Endocrinology. 2007 Mar; 148(3):1288-95. view on PubMed
Walker DW, Hájek P, Muffat J, Knoepfle D, Cornelison S, Attardi G, Benzer S. Hypersensitivity to oxygen and shortened lifespan in a Drosophila mitochondrial complex II mutant. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16382-7. view on PubMed
Dickinson H, Walker DW, Wintour EM, Moritz K. Maternal dexamethasone treatment at midgestation reduces nephron number and alters renal gene expression in the fetal spiny mouse. Am J Physiol Regul Integr Comp Physiol. 2007 Jan; 292(1):R453-61. view on PubMed
Billiards SS, Nguyen PN, Scheerlinck JP, Phillips DJ, Canny BJ, Walker DW, Hirst JJ. Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain. Biol Neonate. 2006; 90(4):258-67. view on PubMed
Walker DW, Muffat J, Rundel C, Benzer S. Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol. 2006 Apr 04; 16(7):674-9. view on PubMed
Zheng J, Edelman SW, Tharmarajah G, Walker DW, Pletcher SD, Seroude L. Differential patterns of apoptosis in response to aging in Drosophila. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12083-8. view on PubMed
McClure L, O'Connor AE, Hayward S, Jenkin G, Walker DW, Phillips DJ. Effects of age and pregnancy on the circulatory activin response of sheep to acute inflammatory challenge by lipopolysaccharide. J Endocrinol. 2005 Apr; 185(1):139-49. view on PubMed
Castillo-Meléndez M, Yan E, Walker DW. Expression of erythropoietin and its receptor in the brain of late-gestation fetal sheep, and responses to asphyxia caused by umbilical cord occlusion. Dev Neurosci. 2005 Mar-Aug; 27(2-4):220-7. view on PubMed
Miller SL, Yan EB, Castillo-Meléndez M, Jenkin G, Walker DW. Melatonin provides neuroprotection in the late-gestation fetal sheep brain in response to umbilical cord occlusion. Dev Neurosci. 2005 Mar-Aug; 27(2-4):200-10. view on PubMed
Dickinson H, Walker DW, Cullen-McEwen L, Wintour EM, Moritz K. The spiny mouse (Acomys cahirinus) completes nephrogenesis before birth. Am J Physiol Renal Physiol. 2005 Aug; 289(2):F273-9. view on PubMed
Yan EB, Unthank JK, Castillo-Melendez M, Miller SL, Langford SJ, Walker DW. Novel method for in vivo hydroxyl radical measurement by microdialysis in fetal sheep brain in utero. J Appl Physiol (1985). 2005 Jun; 98(6):2304-10. view on PubMed
Avis NJ, Grimstead IJ, Walker DW. Grid enabled remote visualization of medical datasets. Stud Health Technol Inform. 2005; 111:22-8. view on PubMed
Manuelpillai U, Ligam P, Smythe G, Wallace EM, Hirst J, Walker DW. Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: up-regulation by inflammatory stimuli and with clinical infection. Am J Obstet Gynecol. 2005 Jan; 192(1):280-8. view on PubMed
Nguyen PN, Yan EB, Castillo-Melendez M, Walker DW, Hirst JJ. Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion. J Physiol. 2004 Oct 15; 560(Pt 2):593-602. view on PubMed
Nguyen PN, Ross Young I, Walker DW, Hirst JJ. Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep. J Endocrinol. 2004 Jul; 182(1):81-8. view on PubMed
Walker DW, Benzer S. Mitochondrial "swirls" induced by oxygen stress and in the Drosophila mutant hyperswirl. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10290-5. view on PubMed
Castillo-Meléndez M, Chow JA, Walker DW. Lipid peroxidation, caspase-3 immunoreactivity, and pyknosis in late-gestation fetal sheep brain after umbilical cord occlusion. Pediatr Res. 2004 May; 55(5):864-71. view on PubMed
Crossley KJ, Nitsos I, Walker DW, Lawrence AJ, Beart PM, Hirst JJ. Steroid-sensitive GABAA receptors in the fetal sheep brain. Neuropharmacology. 2003 Sep; 45(4):461-72. view on PubMed
Nguyen PN, Billiards SS, Walker DW, Hirst JJ. Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolization. Pediatr Res. 2003 Dec; 54(6):840-7. view on PubMed
Thinschmidt JS, Walker DW, King MA. Chronic ethanol treatment reduces the magnitude of hippocampal LTD in the adult rat. Synapse. 2003 Jun 15; 48(4):189-97. view on PubMed
Craig A, Ling Luo N, Beardsley DJ, Wingate-Pearse N, Walker DW, Hohimer AR, Back SA. Quantitative analysis of perinatal rodent oligodendrocyte lineage progression and its correlation with human. Exp Neurol. 2003 Jun; 181(2):231-40. view on PubMed
Nguyen PN, Billiards SS, Walker DW, Hirst JJ. Changes in 5alpha-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep. Pediatr Res. 2003 Jun; 53(6):956-64. view on PubMed
Billiards SS, Walker DW, Canny BJ, Hirst JJ. Endotoxin increases sleep and brain allopregnanolone concentrations in newborn lambs. Pediatr Res. 2002 Dec; 52(6):892-9. view on PubMed
Miller R, King MA, Heaton MB, Walker DW. The effects of chronic ethanol consumption on neurotrophins and their receptors in the rat hippocampus and basal forebrain. Brain Res. 2002 Sep 20; 950(1-2):137-47. view on PubMed
Lee B, Hirst JJ, Walker DW. Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero. J Neurosci. 2002 Jul 01; 22(13):5679-86. view on PubMed
GuhaThakurta D, Palomar L, Stormo GD, Tedesco P, Johnson TE, Walker DW, Lithgow G, Kim S, Link CD. Identification of a novel cis-regulatory element involved in the heat shock response in Caenorhabditis elegans using microarray gene expression and computational methods. Genome Res. 2002 May; 12(5):701-12. view on PubMed
Smythe GA, Braga O, Brew BJ, Grant RS, Guillemin GJ, Kerr SJ, Walker DW. Concurrent quantification of quinolinic, picolinic, and nicotinic acids using electron-capture negative-ion gas chromatography-mass spectrometry. Anal Biochem. 2002 Feb 01; 301(1):21-6. view on PubMed
Nicholls T, Nitsos I, Smythe G, Walker DW. Kynurenine production and catabolism in fetal sheep with embolized or nonembolized placentas. Am J Obstet Gynecol. 2001 Oct; 185(4):988-95. view on PubMed
Nicol MB, Hirst JJ, Walker DW. Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep. Neurosci Lett. 2001 Jun 22; 306(1-2):13-6. view on PubMed
Li Y, Walker DW, King MA. Peroxide mediates ethanol-induced cytotoxicity in PC12 cells. Free Radic Biol Med. 2001 Feb 15; 30(4):389-92. view on PubMed
Nicholls T, Lacey B, Nitsos I, Smythe G, Walker DW. Regional changes in kynurenic acid, quinolinic acid, and glial fibrillary acidic protein concentrations in the fetal sheep brain after experimentally induced placental insufficiency. Am J Obstet Gynecol. 2001 Jan; 184(2):203-8. view on PubMed
Petratos S, Hirst JJ, Mendis S, Anikijenko P, Walker DW. Localization of p450scc and 5alpha-reductase type-2 in the cerebellum of fetal and newborn sheep. Brain Res Dev Brain Res. 2000 Sep 30; 123(1):81-6. view on PubMed
Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ. Extension of life-span with superoxide dismutase/catalase mimetics. Science. 2000 Sep 01; 289(5484):1567-9. view on PubMed
Crossley KJ, Walker DW, Beart PM, Hirst JJ. Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone. Neuropharmacology. 2000 Jul 10; 39(9):1514-22. view on PubMed
McColl G, Jenkins NL, Walker DW, Lithgow GJ. Testing evolutionary theories of aging. Ann N Y Acad Sci. 2000 Jun; 908:319-20. view on PubMed
Walker DW, McColl G, Jenkins NL, Harris J, Lithgow GJ. Evolution of lifespan in C. elegans. Nature. 2000 May 18; 405(6784):296-7. view on PubMed
Heaton MB, Mitchell JJ, Paiva M, Walker DW. Ethanol-induced alterations in the expression of neurotrophic factors in the developing rat central nervous system. Brain Res Dev Brain Res. 2000 May 11; 121(1):97-107. view on PubMed
Hirst JJ, Egodagamage KC, Walker DW. Effect of a neuroactive steroid infused into the cerebral ventricles of fetal sheep in utero using small infusion volumes. J Neurosci Methods. 2000 Apr 01; 97(1):37-44. view on PubMed
West JM, Williams NA, Luff AR, Walker DW. Effect of tibial bone resection on the development of fast- and slow-twitch skeletal muscles in foetal sheep. J Muscle Res Cell Motil. 2000 Apr; 21(3):209-22. view on PubMed
Walker DW, Lee B, Nitsos I. Effect of hypoxia on respiratory activity in the foetus. Clin Exp Pharmacol Physiol. 2000 Jan-Feb; 27(1-2):110-3. view on PubMed
Thinschmidt JS, Webb B, Martin DE, Feldman DH, King MA, Walker DW. The development and pharmacological characterization of calcium channel currents in cultured embryonic rat septal cells. Brain Res Dev Brain Res. 1999 Dec 10; 118(1-2):13-21. view on PubMed
Nicholls T, Nitsos I, Walker DW. Tryptophan metabolism in pregnant sheep: increased fetal kynurenine production in response to maternal tryptophan loading. Am J Obstet Gynecol. 1999 Dec; 181(6):1452-60. view on PubMed
Hu M, Walker DW, Vickroy TW, Peris J. Chronic ethanol exposure increases 3H-GABA release in rat hippocampus by presynaptic muscarinic receptor modulation. Alcohol Clin Exp Res. 1999 Oct; 23(10):1587-95. view on PubMed
Babar P, Adamson C, Walker GA, Walker DW, Lithgow GJ. P13-kinase inhibition induces dauer formation, thermotolerance and longevity in C. elegans. Neurobiol Aging. 1999 Sep-Oct; 20(5):513-9. view on PubMed
Moore DB, Walker DW, Heaton MB. Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis. Alcohol Clin Exp Res. 1999 Jul; 23(7):1251-61. view on PubMed
Walker DW, Curtis B, Lacey B, Nitsos I. Kynurenic acid in brain and cerebrospinal fluid of fetal, newborn, and adult sheep and effects of placental embolization. Pediatr Res. 1999 Jun; 45(6):820-6. view on PubMed
Miller SL, Jenkin G, Walker DW. Effect of nitric oxide synthase inhibition on the uterine vasculature of the late-pregnant ewe. Am J Obstet Gynecol. 1999 May; 180(5):1138-45. view on PubMed
Nitsos I, Walker DW. Characterization of pontine neurons which respond to hypoxia in fetal sheep. Neurosci Lett. 1999 Apr 30; 266(1):33-6. view on PubMed
Nitsos I, Walker DW. The distribution of FOS-immunoreactive neurons in the brainstem, midbrain and diencephalon of fetal sheep in response to acute hypoxia in mid and late gestation. Brain Res Dev Brain Res. 1999 Apr 12; 114(1):9-26. view on PubMed
West JM, Barclay CJ, Luff AR, Walker DW. Developmental changes in the activation properties and ultrastructure of fast- and slow-twitch muscles from fetal sheep. J Muscle Res Cell Motil. 1999 Apr; 20(3):249-64. view on PubMed
Lee B, Nitsos I, Walker DW. Effects of the respiratory stimulant almitrine on breathing and FOS expression in the brain of fetal and newborn sheep. Pediatr Res. 1999 Apr; 45(4 Pt 1):531-43. view on PubMed
Mitchell JJ, Paiva M, Walker DW, Heaton MB. BDNF and NGF afford in vitro neuroprotection against ethanol combined with acute ischemia and chronic hypoglycemia. Dev Neurosci. 1999; 21(1):68-75. view on PubMed
Miller SL, Jenkin G, Walker DW. Effects of hyperthermia on uterine blood flow and shunting through uterine arteriovenous anastomoses in the late-pregnant ewe. Reprod Fertil Dev. 1999; 11(4-5):201-9. view on PubMed
Barrow Heaton MB, Kidd K, Bradley D, Paiva M, Mitchell J, Walker DW. Prenatal ethanol exposure reduces spinal cord motoneuron number in the fetal rat but does not affect GDNF target tissue protein. Dev Neurosci. 1999; 21(6):444-52. view on PubMed
Nicol MB, Hirst JJ, Walker DW. Effect of pregnane steroids on electrocortical activity and somatosensory evoked potentials in fetal sheep. Neurosci Lett. 1998 Sep 04; 253(2):111-4. view on PubMed
Walker GA, Walker DW, Lithgow GJ. A relationship between thermotolerance and longevity in Caenorhabditis elegans. J Investig Dermatol Symp Proc. 1998 Aug; 3(1):6-10. view on PubMed
Walker GA, Walker DW, Lithgow GJ. Genes that determine both thermotolerance and rate of aging in Caenorhabditis elegans. Ann N Y Acad Sci. 1998 Jun 30; 851:444-9. view on PubMed
Moore DB, Quintero MA, Ruygrok AC, Walker DW, Heaton MB. Prenatal ethanol exposure reduces parvalbumin-immunoreactive GABAergic neuronal number in the adult rat cingulate cortex. Neurosci Lett. 1998 Jun 12; 249(1):25-8. view on PubMed
Read PA, Horne RS, Cranage SM, Walker AM, Walker DW, Adamson TM. Dynamic changes in arousal threshold during sleep in the human infant. Pediatr Res. 1998 May; 43(5):697-703. view on PubMed
Moore DB, Lee P, Paiva M, Walker DW, Heaton MB. Effects of neonatal ethanol exposure on cholinergic neurons of the rat medial septum. Alcohol. 1998 Apr; 15(3):219-26. view on PubMed
Mitchell JJ, Paiva M, Moore DB, Walker DW, Heaton MB. A comparative study of ethanol, hypoglycemia, hypoxia and neurotrophic factor interactions with fetal rat hippocampal neurons: a multi-factor in vitro model developmental ethanol effects. Brain Res Dev Brain Res. 1998 Feb 10; 105(2):241-50. view on PubMed
Miller SL, Dickson K, Jenkin G, Walker DW. Physiological evidence for arteriovenous anastomoses in the uterine circulation of late-pregnant ewes. Clin Exp Pharmacol Physiol. 1998 Feb; 25(2):92-8. view on PubMed
Walker DW, Pratt N. Effect of probenecid on breathing movements and cerebral clearance of prostaglandin E2 in fetal sheep. J Physiol. 1998 Jan 01; 506 ( Pt 1):253-62. view on PubMed
McGregor HP, Westcott K, Walker DW. The effect of prenatal exposure to carbon monoxide on breathing and growth of the newborn guinea pig. Pediatr Res. 1998 Jan; 43(1):126-31. view on PubMed
Webb B, Suarez SS, Heaton MB, Walker DW. Cultured postnatal rat septohippocampal neurons change intracellular calcium in response to ethanol and nerve growth factor. Brain Res. 1997 Dec 19; 778(2):354-66. view on PubMed
Peris J, Eppler B, Hu M, Walker DW, Hunter BE, Mason K, Anderson KJ. Effects of chronic ethanol exposure on GABA receptors and GABAB receptor modulation of 3H-GABA release in the hippocampus. Alcohol Clin Exp Res. 1997 Sep; 21(6):1047-52. view on PubMed
Moore DB, Ruygrok AC, Walker DW, Heaton MB. Effects of prenatal ethanol exposure on parvalbumin-expressing GABAergic neurons in the adult rat medial septum. Alcohol Clin Exp Res. 1997 Aug; 21(5):849-56. view on PubMed
Peris J, Anderson KJ, Vickroy TW, King MA, Hunter BE, Walker DW. Neurochemical basis of disruption of hippocampal long term potentiation by chronic alcohol exposure. Front Biosci. 1997 Jun 15; 2:d309-16. view on PubMed
King MA, Thinschmidt JS, Walker DW. Gammahydroxybutyrate (GHB) receptor ligand effects on evoked synaptic field potentials in CA1 of the rat hippocampal slice. J Neural Transm (Vienna). 1997; 104(11-12):1177-93. view on PubMed
Crossley KJ, Nicol MB, Hirst JJ, Walker DW, Thorburn GD. Suppression of arousal by progesterone in fetal sheep. Reprod Fertil Dev. 1997; 9(8):767-73. view on PubMed
Webb B, Suarez SS, Heaton MB, Walker DW. Cultured postnatal rat medial septal neurons respond to acute ethanol treatment and nerve growth factor by changing intracellular calcium levels. Alcohol Clin Exp Res. 1996 Nov; 20(8):1385-94. view on PubMed
Webb B, Suarez SS, Heaton MB, Walker DW. Calcium homeostasis in cultured embryonic rat septohippocampal neurons is altered by ethanol and nerve growth factor before and during depolarization. Brain Res. 1996 Aug 12; 729(2):176-89. view on PubMed
Swanson DJ, Tonjes L, King MA, Walker DW, Heaton MB. Influence of chronic prenatal ethanol on cholinergic neurons of the septohippocampal system. J Comp Neurol. 1996 Jan 01; 364(1):104-12. view on PubMed
Heaton MB, Swanson DJ, Paiva M, Walker DW. Influence of prenatal ethanol exposure on cholinergic development in the rat striatum. J Comp Neurol. 1996 Jan 01; 364(1):113-20. view on PubMed
Webb B, Suarez SS, Heaton MB, Walker DW. Ethanol and nerve growth factor effects on calcium homeostasis in cultured embryonic rat medial septal neurons before and during depolarization. Brain Res. 1995 Dec 01; 701(1-2):61-74. view on PubMed
Swanson DJ, King MA, Walker DW, Heaton MB. Chronic prenatal ethanol exposure alters the normal ontogeny of choline acetyltransferase activity in the rat septohippocampal system. Alcohol Clin Exp Res. 1995 Oct; 19(5):1252-60. view on PubMed
MacLennan AJ, Lee N, Walker DW. Chronic ethanol administration decreases brain-derived neurotrophic factor gene expression in the rat hippocampus. Neurosci Lett. 1995 Sep 08; 197(2):105-8. view on PubMed
Walker DW, Hale JR, Fawcett AA, Pratt NM. Cardiovascular responses to heat stress in late gestation fetal sheep. Exp Physiol. 1995 Sep; 80(5):755-66. view on PubMed
Walker DW. Hypoxic inhibition of breathing and motor activity in the foetus and newborn. Clin Exp Pharmacol Physiol. 1995 Aug; 22(8):533-6. view on PubMed
Heaton MB, Paiva M, Swanson DJ, Walker DW. Prenatal ethanol exposure alters neurotrophic activity in the developing rat hippocampus. Neurosci Lett. 1995 Mar 24; 188(2):132-6. view on PubMed
Heaton MB, Paiva M, Swanson DJ, Walker DW. Alterations in responsiveness to ethanol and neurotrophic substances in fetal septohippocampal neurons following chronic prenatal ethanol exposure. Brain Res Dev Brain Res. 1995 Mar 16; 85(1):1-13. view on PubMed
Hooper SB, Walker DW, Harding R. Oxygen, glucose, and lactate uptake by fetus and placenta during prolonged hypoxemia. Am J Physiol. 1995 Feb; 268(2 Pt 2):R303-9. view on PubMed
Webb B, Heaton MB, King MA, Walker DW. A method for labeling embryonic rat medial septal region projection neurons, in vitro, using fluorescent tracers. Brain Res Bull. 1995; 37(3):317-23. view on PubMed
Walker DW, Luff AR. Functional development of fetal limb muscles: a review of the roles of activity, nerves and hormones. Reprod Fertil Dev. 1995; 7(3):391-8. view on PubMed
MacLennan AJ, Lee N, Vincent SR, Walker DW. D2 dopamine receptor mRNA distribution in cholinergic and somatostatinergic cells of the rat caudate-putamen and nucleus accumbens. Neurosci Lett. 1994 Oct 24; 180(2):214-8. view on PubMed
Fielke SL, Young IR, Walker DW, McMillen IC. Effect of two weeks of continuous light on the development of the circadian melatonin rhythm in newborn lambs. J Pineal Res. 1994 Oct; 17(3):118-22. view on PubMed
Heaton MB, Paiva M, Swanson DJ, Walker DW. Ethanol neurotoxicity in vitro: effects of GM1 ganglioside and protein synthesis inhibition. Brain Res. 1994 Aug 22; 654(2):336-42. view on PubMed
Johnston R, Walker DW, Adamson TM, Westerman RA. Forehead and forearm skin blood flows in newborn infants measured by laser Doppler flowmetry: short-term variability and relationship to sleep states. Early Hum Dev. 1994 Apr 30; 37(1):45-55. view on PubMed
Joseph SA, Walker DW. Monoamine concentrations in cerebrospinal fluid of fetal and newborn sheep. Am J Physiol. 1994 Feb; 266(2 Pt 2):R472-80. view on PubMed
Houghton DC, Walker DW, Young IR, McMillen IC. Melatonin and the light-dark cycle separately influence daily behavioral and hormonal rhythms in the pregnant ewe and sheep fetus. Endocrinology. 1993 Jul; 133(1):90-8. view on PubMed
Joseph SA, Walker DW. Effects of intracisternal monoamines on breathing movements in fetal sheep. Am J Physiol. 1993 Jun; 264(6 Pt 2):R1139-49. view on PubMed
Walker DW, Heaton MB, Lee N, King MA, Hunter BE. Effect of chronic ethanol on the septohippocampal system: a role for neurotrophic factors? Alcohol Clin Exp Res. 1993 Feb; 17(1):12-8. view on PubMed
Walker DW, Lee N, Heaton MB, King MA, Hunter BE. Chronic ethanol consumption reduces the neurotrophic activity in rat hippocampus. Neurosci Lett. 1992 Nov 23; 147(1):77-80. view on PubMed
Finkelstein DI, Andrianakis P, Luff AR, Walker DW. Developmental changes in hindlimb muscles and diaphragm of sheep. Am J Physiol. 1992 Oct; 263(4 Pt 2):R900-8. view on PubMed
McMillen IC, Walker DW. Effects of different lighting regimes on daily hormonal and behavioural rhythms in the pregnant ewe and sheep fetus. J Physiol. 1991 Oct; 442:465-76. view on PubMed
McMillen IC, Walker DW, Young IR, Nowak R. A daily prolactin rhythm persists in the ewe, foetus and newborn lamb after maternal pinealectomy in late gestation. J Neuroendocrinol. 1991 Aug 01; 3(4):369-74. view on PubMed
Simonetta G, Walker DW, McMillen IC. Effect of feeding on the diurnal rhythm of plasma cortisol and adrenocorticotrophic hormone concentrations in the pregnant ewe and sheep fetus. Exp Physiol. 1991 Mar; 76(2):219-29. view on PubMed
Joseph SA, Walker DW. Catecholamine neurons in fetal brain: effects on breathing movements and electrocorticogram. J Appl Physiol (1985). 1990 Nov; 69(5):1903-11. view on PubMed
Chang DJ, Paik YK, Leren TP, Walker DW, Howlett GJ, Taylor JM. Characterization of a human apolipoprotein E gene enhancer element and its associated protein factors. J Biol Chem. 1990 Jun 05; 265(16):9496-504. view on PubMed
Callea J, McMillen IC, Walker DW. Effect of feeding regimen on diurnal variation of breathing movements in late-gestation fetal sheep. J Appl Physiol (1985). 1990 May; 68(5):1786-92. view on PubMed
Walker DW, Davies AN, McMillen IC. Effect of hyperthermia on the plasma concentrations of prolactin and cortisol in the fetal lamb and pregnant ewe during late gestation. J Dev Physiol. 1990 Mar; 13(3):173-7. view on PubMed
Andrianakis P, Stephenson RG, Walker DW. Effect of hyperthermia on thyroid structure in the late gestation fetal lamb. Biol Neonate. 1990; 57(3-4):224-30. view on PubMed
McMillen IC, Nowak R, Walker DW, Young IR. Maternal pinealectomy alters the daily pattern of fetal breathing in sheep. Am J Physiol. 1990 Jan; 258(1 Pt 2):R284-7. view on PubMed
Walker DW, Schuijers JA. Effect of thyroidectomy on cardiovascular responses to hypoxia and tyramine infusion in fetal sheep. J Dev Physiol. 1989 Dec; 12(6):337-45. view on PubMed
Andrianakis P, Walker DW, Ralph MM, Thorburn GD. Effects of hyperthermia on fetal and maternal plasma prostaglandin concentrations and uterine activity in sheep. Prostaglandins. 1989 Nov; 38(5):541-55. view on PubMed
Rachamin G, Luttge WG, Hunter BE, Walker DW. Neither chronic exposure to ethanol nor aging affects type I or type II corticosteroid receptors in rat hippocampus. Exp Neurol. 1989 Nov; 106(2):164-71. view on PubMed
King MA, Louis PM, Hunter BE, Walker DW. Biocytin: a versatile anterograde neuroanatomical tract-tracing alternative. Brain Res. 1989 Sep 18; 497(2):361-7. view on PubMed
Andrianakis P, Walker DW, Ralph MM, Thorburn GD. Effect of inhibiting prostaglandin synthesis in pregnant sheep with 4-aminoantipyrine under normothermic and hyperthermic conditions. Am J Obstet Gynecol. 1989 Jul; 161(1):241-7. view on PubMed
King MA, Hunter BE, Reep RL, Walker DW. Acetylcholinesterase stain intensity variation in the rat dentate gyrus: a quantitative description based on digital image analysis. Neuroscience. 1989; 33(1):203-21. view on PubMed
Jones CT, Roebuck MM, Walker DW, Johnston BM. Modulation of the responses of fetal sheep to adrenergic stimulation by adrenal demedullation and chemical sympathectomy. J Dev Physiol. 1989 Jan; 11(1):45-54. view on PubMed
Walker DW. Effects of increased core temperature on breathing movements and electrocortical activity in fetal sheep. J Dev Physiol. 1988 Dec; 10(6):513-23. view on PubMed
King MA, Hunter BE, Walker DW. Alterations and recovery of dendritic spine density in rat hippocampus following long-term ethanol ingestion. Brain Res. 1988 Sep 06; 459(2):381-5. view on PubMed
Zemdegs IZ, McMillen IC, Walker DW, Thorburn GD, Nowak R. Diurnal rhythms in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation. Endocrinology. 1988 Jul; 123(1):284-9. view on PubMed
Orona E, Hunter BE, Walker DW. Ethanol exposure following unilateral entorhinal deafferentation alters synaptic reorganization in the rat dentate gyrus: a quantitative analysis of acetylcholinesterase histochemistry. Exp Neurol. 1988 Jul; 101(1):114-31. view on PubMed
Jones CT, Roebuck MM, Walker DW, Johnston BM. The role of the adrenal medulla and peripheral sympathetic nerves in the physiological responses of the fetal sheep to hypoxia. J Dev Physiol. 1988 Feb; 10(1):17-36. view on PubMed
Jones CT, Roebuck MM, Walker DW, Lagercrantz H, Johnston BM. Cardiovascular, metabolic and endocrine effects of chemical sympathectomy and of adrenal demedullation in fetal sheep. J Dev Physiol. 1987 Aug; 9(4):347-67. view on PubMed
McMillen IC, Thorburn GD, Walker DW. Diurnal variations in plasma concentrations of cortisol, prolactin, growth hormone and glucose in the fetal sheep and pregnant ewe during late gestation. J Endocrinol. 1987 Jul; 114(1):65-72. view on PubMed
Elshourbagy NA, Walker DW, Paik YK, Boguski MS, Freeman M, Gordon JI, Taylor JM. Structure and expression of the human apolipoprotein A-IV gene. J Biol Chem. 1987 Jun 15; 262(17):7973-81. view on PubMed
Wickham PJ, Walker DW. Analysis of fetal breathing in real time using a microprocessor. J Appl Physiol (1985). 1987 Apr; 62(4):1733-9. view on PubMed
Joseph SA, McMillen IC, Walker DW. Effects of naloxone on breathing movements during hypercapnia in the fetal lamb. J Appl Physiol (1985). 1987 Feb; 62(2):673-8. view on PubMed
Schuijers JA, Walker DW, Browne CA, Thorburn GD. Peripheral and brain tissue catecholamine content in intact and anti-NGF-treated fetal sheep. Am J Physiol. 1987 Jan; 252(1 Pt 2):R7-12. view on PubMed
Walker DW, Davies AN. Effects of hyperthermia on fetal breathing movements. J Dev Physiol. 1986 Dec; 8(6):485-97. view on PubMed
Schuijers JA, Walker DW, Browne CA, Thorburn GD. Effect of hypoxemia on plasma catecholamines in intact and immunosympathectomized fetal lambs. Am J Physiol. 1986 Nov; 251(5 Pt 2):R893-900. view on PubMed
McMillen IC, Walker DW. Effect of beta-endorphin on fetal breathing movements in sheep. J Appl Physiol (1985). 1986 Sep; 61(3):1005-11. view on PubMed
Hooper SB, Walker DW, Thorburn GD. Cannulation of the utero-ovarian vein in intact ewes: hormone concentrations and blood gas levels during the oestrous cycle and early pregnancy. Acta Endocrinol (Copenh). 1986 Jun; 112(2):253-62. view on PubMed
Walker DW, Harding R. The effects of raising intracranial pressure on breathing movements, eye movements and electrocortical activity in fetal sheep. J Dev Physiol. 1986 Apr; 8(2):105-16. view on PubMed
Elshourbagy NA, Walker DW, Boguski MS, Gordon JI, Taylor JM. The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III. J Biol Chem. 1986 Feb 15; 261(5):1998-2002. view on PubMed
King MA, Reep RL, Hunter BE, Walker DW. The three-dimensional morphology of afferent terminal fields in the rat dentate gyrus: periodic variation. J Comp Neurol. 1985 Apr 15; 234(3):334-43. view on PubMed
Walker DW, Harding R. Effect of hypoxia on the excitability of two cranial reflexes in unanaesthetized fetal sheep. J Dev Physiol. 1984 Oct; 6(5):387-99. view on PubMed
Walker DW. Brain mechanisms, hypoxia and fetal breathing. J Dev Physiol. 1984 Jun; 6(3):225-36. view on PubMed
Johnston BM, Walker DW, Green AR. Lack of long term effect of p-chlorophenylalanine on brain 5-hydroxytryptamine and electrocortical activity in conscious fetal sheep. Experientia. 1984 Mar 15; 40(3):291-4. view on PubMed
Walker DW. Peripheral and central chemoreceptors in the fetus and newborn. Annu Rev Physiol. 1984; 46:687-703. view on PubMed
Clewlow F, Dawes GS, Johnston BM, Walker DW. Changes in breathing, electrocortical and muscle activity in unanaesthetized fetal lambs with age. J Physiol. 1983 Aug; 341:463-76. view on PubMed
Blanco CE, Dawes GS, Walker DW. Effect of hypoxia on polysynaptic hind-limb reflexes of unanaesthetized fetal and new-born lambs. J Physiol. 1983 Jun; 339:453-66. view on PubMed
Blanco CE, Dawes GS, Walker DW. Effects of hypoxia on polysynaptic hind-limb reflexes in new-born lambs before and after carotid denervation. J Physiol. 1983 Jun; 339:467-74. view on PubMed
Dawes GS, Gardner WN, Johnston BM, Walker DW. Breathing in fetal lambs: the effect of brain stem section. J Physiol. 1983 Feb; 335:535-53. view on PubMed
Rigatto H, Blanco CE, Walker DW. The response to stimulation of hindlimb nerves in fetal sheep, in utero, during the different phases of electrocortical activity. J Dev Physiol. 1982 Jun; 4(3):175-85. view on PubMed
Dawes GS, Gardner WN, Johnston BM, Walker DW. Effects of hypercapnia on tracheal pressure, diaphragm and intercostal electromyograms in unanaesthetized fetal lambs. J Physiol. 1982 May; 326:461-74. view on PubMed
Quilligan EJ, Clewlow F, Johnston BM, Walker DW. Effect of 5-hydroxytryptophan on electrocortical activity and breathing movements of fetal sheep. Am J Obstet Gynecol. 1981 Oct 01; 141(3):271-5. view on PubMed
Barnes DE, Walker DW. Prenatal ethanol exposure permanently reduces the number of pyramidal neurons in rat hippocampus. Brain Res. 1981 Jun; 227(3):333-40. view on PubMed
Dawes GS, Walker DW, Johnston BM. The central control of fetal breathing and movements. Ciba Found Symp. 1981; 86:295-307. view on PubMed
Dawes GS, Johnston BM, Walker DW. Relationship of arterial pressure and heart rate in fetal, new-born and adult sheep. J Physiol. 1980 Dec; 309:405-17. view on PubMed
Poore ER, Walker DW. Chest wall movements during fetal breathing in the sheep. J Physiol. 1980 Apr; 301:307-15. view on PubMed
Mitchell MD, Brunt J, Clover L, Walker DW. Prostaglandins in the umbilical and uterine circulations during late pregnancy in the ewe. J Reprod Fertil. 1980 Mar; 58(2):283-7. view on PubMed
Hunter BE, Walker DW. The neural basis of ethanol dependence: is the withdrawal reaction mediated by localized changes in synaptic excitability? Adv Exp Med Biol. 1980; 126:251-69. view on PubMed
Hunter BE, Walker DW. Ethanol dependence in the rat: role of extrapyramidal motor systems in the withdrawal reaction. Exp Neurol. 1978 Nov; 62(2):374-93. view on PubMed
Geisler RF, Hunter BE, Walker DW. Ethanol dependence in the rat: temporal changes in neuroexcitability following withdrawal. Psychopharmacology (Berl). 1978 Apr 11; 56(3):287-92. view on PubMed
Walker DW, Mitchell MD. Prostaglandins in urine of foetal lambs. Nature. 1978 Jan 12; 271(5641):161-2. view on PubMed
Walker DW. Effect of hypoxia on glomerular filtration rate, urine flow and urine composition in chronically catheterized foetal lambs [proceedings]. J Physiol. 1977 Oct; 272(1):15P-16P. view on PubMed
Walker DW. Placental clearance of antipyrine and urea during hypoxia and adrenaline infusions in sheep [proceedings]. J Physiol. 1977 Oct; 271(2):65P-66P. view on PubMed
Randall CL, Taylor J, Walker DW. Ethanol-induced malformations in mice. Alcohol Clin Exp Res. 1977 Jul; 1(3):219-24. view on PubMed
Walker DW. Renal function and micturition in fetal lambs, and the effects of hypoxia. Ann Rech Vet. 1977; 8(4):497-8. view on PubMed
Walker DW, Zornetzer SF. Alcohol withdrawal in mice: electroencephalographic and behavioral correlates. Electroencephalogr Clin Neurophysiol. 1974 Mar; 36(3):233-43. view on PubMed
Hunter BE, Boast CA, Walker DW, Zornetzer SF. Alcohol withdrawal syndrome in rats: neural and behavioral correlates. Pharmacol Biochem Behav. 1973 Nov-Dec; 1(6):719-25. view on PubMed
Grimwade JC, Walker DW, Bartlett M, Gordon S, Wood C. Human fetal heart rate change and movement in response to sound and vibration. Am J Obstet Gynecol. 1971 Jan 01; 109(1):86-90. view on PubMed
Walker DW, Wood C. Temperature relationship of the mother and fetus during labor. Am J Obstet Gynecol. 1970 May 01; 107(1):83-7. view on PubMed
Walker A, Talbot JM, Walker DW, Newman W. Technique for physiological measurement in the human fetus. Lancet. 1969 Jul 05; 2(7610):31-2. view on PubMed
