Jimmy Hu*

/in /by

Publications:

Du W, Verma A, Ye Q, Du W, Lin S, Yamanaka A, Klein OD, Hu JK. Myosin II mediates Shh signals to shape dental epithelia via control of cell adhesion and movement. PLoS Genet. 2024 Jun; 20(6):e1011326. view on PubMed

Shroff NP, Xu P, Kim S, Shelton ER, Gross BJ, Liu Y, Gomez CO, Ye Q, Drennon TY, Hu JK, Green JBA, Campàs O, Klein OD. Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nat Cell Biol. 2024 Apr; 26(4):519-529. view on PubMed

Sundari Thooyamani A, Shahin E, Takano S, Sharir A, Hu JK. Using Ex Vivo Live Imaging to Investigate Cell Divisions and Movements During Mouse Dental Renewal. J Vis Exp. 2023 10 27; (200). view on PubMed

Hu JK. Nail mesenchyme: Tipping the hand on regeneration. Cell Rep. 2023 01 31; 42(1):111960. view on PubMed

Ye Q, Bhojwani A, Hu JK. Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 08 15; 149(16). view on PubMed

Du W, Bhojwani A, Hu JK. FACEts of mechanical regulation in the morphogenesis of craniofacial structures. Int J Oral Sci. 2021 02 05; 13(1):4. view on PubMed

Alsamman S, Christenson SA, Yu A, Ayad NME, Mooring MS, Segal JM, Hu JK, Schaub JR, Ho SS, Rao V, Marlow MM, Turner SM, Sedki M, Pantano L, Ghoshal S, Ferreira DDS, Ma HY, Duwaerts CC, Espanol-Suner R, Wei L, Newcomb B, Mileva I, Canals D, Hannun YA, Chung RT, Mattis AN, Fuchs BC, Tager AM, Yimlamai D, Weaver VM, Mullen AC, Sheppard D, Chen JY. Targeting acid ceramidase inhibits YAP/TAZ signaling to reduce fibrosis in mice. Sci Transl Med. 2020 08 19; 12(557). view on PubMed

Kindberg A, Hu JK, Bush JO. Forced to communicate: Integration of mechanical and biochemical signaling in morphogenesis. Curr Opin Cell Biol. 2020 10; 66:59-68. view on PubMed

Sharir A, Marangoni P, Zilionis R, Wan M, Wald T, Hu JK, Kawaguchi K, Castillo-Azofeifa D, Epstein L, Harrington K, Pagella P, Mitsiadis T, Siebel CW, Klein AM, Klein OD. A large pool of actively cycling progenitors orchestrates self-renewal and injury repair of an ectodermal appendage. Nat Cell Biol. 2019 09; 21(9):1102-1112. view on PubMed

Calamari ZT, Hu JK, Klein OD. Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function. Bioessays. 2018 12; 40(12):e1800140. view on PubMed

Du W, Hu JK, Du W, Klein OD. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 09 08; 292(36):15062-15069. view on PubMed

Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD. An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell. 2017 07 06; 21(1):91-106.e6. view on PubMed

Tschopp P, Sherratt E, Sanger TJ, Groner AC, Aspiras AC, Hu JK, Pourquié O, Gros J, Tabin CJ. A relative shift in cloacal location repositions external genitalia in amniote evolution. Nature. 2014 Dec 18; 516(7531):391-4. view on PubMed

Biehs B, Hu JK, Strauli NB, Sangiorgi E, Jung H, Heber RP, Ho S, Goodwin AF, Dasen JS, Capecchi MR, Klein OD. BMI1 represses Ink4a/Arf and Hox genes to regulate stem cells in the rodent incisor. Nat Cell Biol. 2013 Jul; 15(7):846-52. view on PubMed

Hu JK, McGlinn E, Harfe BD, Kardon G, Tabin CJ. Autonomous and nonautonomous roles of Hedgehog signaling in regulating limb muscle formation. Genes Dev. 2012 Sep 15; 26(18):2088-102. view on PubMed

Cooper KL, Hu JK, ten Berge D, Fernandez-Teran M, Ros MA, Tabin CJ. Initiation of proximal-distal patterning in the vertebrate limb by signals and growth. Science. 2011 May 27; 332(6033):1083-6. view on PubMed

Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ. WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud. Curr Biol. 2010 Nov 23; 20(22):1993-2002. view on PubMed

Schlabach MR, Hu JK, Li M, Elledge SJ. Synthetic design of strong promoters. Proc Natl Acad Sci U S A. 2010 Feb 09; 107(6):2538-43. view on PubMed

Purcell P, Joo BW, Hu JK, Tran PV, Calicchio ML, O'Connell DJ, Maas RL, Tabin CJ. Temporomandibular joint formation requires two distinct hedgehog-dependent steps. Proc Natl Acad Sci U S A. 2009 Oct 27; 106(43):18297-302. view on PubMed

Loscertales M, Mikels AJ, Hu JK, Donahoe PK, Roberts DJ. Chick pulmonary Wnt5a directs airway and vascular tubulogenesis. Development. 2008 Apr; 135(7):1365-76. view on PubMed

Horsfield JA, Anagnostou SH, Hu JK, Cho KH, Geisler R, Lieschke G, Crosier KE, Crosier PS. Cohesin-dependent regulation of Runx genes. Development. 2007 Jul; 134(14):2639-49. view on PubMed

Hornstein E, Mansfield JH, Yekta S, Hu JK, Harfe BD, McManus MT, Baskerville S, Bartel DP, Tabin CJ. The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature. 2005 Dec 01; 438(7068):671-4. view on PubMed