Dr. Julia Mack, post-doctoral researcher at the Arispe Lab, publishes as first author in Nature Communications. Her work demonstrates that Notch 1 is a flow sensor and it is required to regulate calcium spokes in the adult endothelium. You can find the article here.
Julia Mack, Thiago Mosqueiro, Brian Archer, William Jones, Hannah Sunshine, Guido Faas, Anais Briot, Raquel Aragón, Yu-Chyuan Su, Milagros Romay, Austin McDonald, Cheng-Hsiang Kuo, Carlos Lizama, Timothy Lane, Ann Zovein, Yun Fang, Elizabeth Tarling, Thomas de Aguiar Vallim, Mohamad Navab, Alan Fogelman, Louis Bouchard, Luisa Iruela-Arispe. NOTCH1 is a mechanosensor in adult arteries. Nature Communications. 8(1): 1621.
“At 2 weeks post endothelial Notch1 deletion, we also observed proliferating endothelial cells (white arrow heads) in the descending aorta (Fig. 5e)”